共查询到20条相似文献,搜索用时 390 毫秒
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碳纳米管因其可以穿透细胞膜和生物体的多重屏障进入细胞和生物体内而在生物医药领域具有广泛应用前景。介绍了碳纳米管的基本性质,概述了碳纳米管聚合物复合材料的生物相容性,并在此基础上综述了其在生物电驱动材料、支架材料以及药物载体等方面应用的最新成果,展望了未来碳纳米管聚合物复合材料在生物医药领域的发展方向。 相似文献
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聚乙烯醇(PVA)是一种水溶性高分子聚合物,常用于眼用制剂、口服制剂、注射剂、微胶囊剂、透皮贴剂、缓释微球及纳米粒等药物载体材料的制备.介绍了水溶性聚乙烯醇材料的特性及型号,以及永溶性PVA作为药物载体材料在制剂及其它药学方面的应用,展望了PVA材料在药物载体材料方面的应用,指出了今后的发展方向和趋势. 相似文献
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Yibin Ren ) Peng Wan ) Feng Liu Bingchun Zhang ) Ke Yang ) ) Institute of Metal Research Chinese Academy of Sciences Shenyang China ) Graduate School of Chinese Academy of Sciences Beijing China 《材料科学技术学报》2011,(4):325-331
Most commercialized coronary stents are made of 316L stainless steels due to its good combination of properties,and currently some new stents are made of cobalt-based alloy owing to its higher mechanical properties. However,the presence of high quantity of nickel and/or cobalt elements in these materials,which are known to trigger the toxic and allergic responses,has caused many concerns.Nickel-free austenitic stainless steels have been developed in order to solve these problems.In this paper,based on the development of a new Fe-Cr-Mn-Mo-N type high nitrogen nickel-free austenitic stainless steel,properties such as mechanical property,corrosion resistance in Hank s solution,and in vitro blood compatibility including the kinetic clotting time and the platelets adhesion,were investigated in comparison to the above two conventional materials,a 316L stainless steel and a Co-28Cr-6Mo alloy.The results showed that the new high nitrogen steel possessed better combination of mechanical properties,corrosion resistance and blood compatibility than those of 316L steel and the Co-28Cr-6Mo alloy,and can be a promising alternative material for manufacture of coronary stents. 相似文献
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H. Brauer J. Stolpmann H. Hallmann R. Erbel A. Fischer 《Materialwissenschaft und Werkstofftechnik》1999,30(12):876-885
Experiments are carried out to examine the dilatation properties of metallic stents. Therefore a test rig has been developed. Also the dilatation behaviour of stents out of different materials are investigated. Additionally numerical simulations of dilatation are carried out. Because balloon expandable stent systems exist of the stent and a balloon catheter, the balloon catheter is examined before the investigation of the stent systems. The results show a reproducible and similar dilatation behaviour for all stents. Titanium as a material with an advanced biocompatibility shows advantages in the dilatation behaviour against the stainless steel stents. A qualitative equality between simulation and measurement of the dilatation behaviour can be noticed. The results indicate the possibility to numerically simulate and to optimise the dilatation behaviour by a combination of simulation and measurement. The preclinical measurement can be reduced to some prototypes. 相似文献
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AbstractTamibarotene-loaded biodegradable matrices with antithrombogenic and drug-releasing properties were prepared in a crosslinking reaction between amino groups of alkali-treated collagen (AlCol) and active ester groups of trisuccinimidyl citrate. The resulting matrices were characterized by their residual amino group concentrations, swelling ratios and thermal, antithrombogenic and drug-releasing properties. It was clarified that the addition of tamibarotene does not inhibit matrix formation. After immersion in water, the swelling ratio of a matrix became lower than that prior to immersion. Thermal analysis indicated that AlCol interacted with tamibarotene. The addition of tamibarotene to the matrix did not influence the antithrombogenic property of the resulting matrix. A matrix with a high crosslinking density had a prolonged tamibarotene elution time. These results demonstrate that tamibarotene-loaded matrices have great potential as a coating material for drug-eluting stents. 相似文献
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《材料与设计》2015
In spite of all innovations in stent design, commonly used metallic stents present several problems such as corrosion, infection and restenosis, leading to health complications or even death of patients. In this context, the present paper reports a systematic investigation on designing and development of 100% fiber based stents, which can eliminate or minimize the problems with existing metallic stents. For this purpose, braided stents were produced by varying different materials, structural and process parameters such as mono-filament type and diameter, braiding angle and mandrel diameter. The influence of these design parameters on mechanical behavior as well as stent's porosity was thoroughly investigated, and suitable parameters were selected for developing a stent with mechanical characteristics and porosity matching with the commercial stents. According to the experimental results, the best performance was achieved with a polyester stent designed with 0.27 mm monofilament diameter, braiding angle of 35° and mandrel diameter of 6 mm, providing similar properties to commercial Nitinol stents. 相似文献
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《工程(英文)》2021,7(7):979-990
Inherent drawbacks associated with drug-eluting stents have prompted the development of bioresorbable cardiovascular stents. Additive manufacturing (3-dimentional (3D) printing) has been widely applied in medical devices. In this study, we develop a novel screw extrusion-based 3D printing system with a new designed mini-screw extruder to fabricate stents. A stent with a zero Poisson’s ratio (ZPR) structure is designed, and a preliminary monofilament test is conducted to investigate appropriate fabrication parameters. 3D-printed stents with different geometric structures are fabricated and analyzed by observation of the surface morphology. An evaluation of the mechanical properties and a preliminary biological evaluation of 3D-printed stents with different parameters are carried out. In conclusion, the screw extrusion-based 3D printing system shows potential for customizable stent fabrication. 相似文献
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J. Stolpmann H. Brauer H.‐J. Stracke R. Erbel A. Fischer 《Materialwissenschaft und Werkstofftechnik》2003,34(8):736-745
After first implantation of a metallic stent into cardiac vessels in 1986 stent implantation has become a standard technique for treatment of coronary heart disease. During implantation of balloon‐expandable stents, the structure of the stent undergoes high plastic deformation. Despite the fact, that stents are used for more than 15 years nearly no information about the mechanical and micro structural process during dilation are known. The present paper presents a detailed study and comparison of the experimental and the simulated expansion behaviour of metallic stents. Used material models are discussed and crystallographic details are presented. Dilation curves describe the behaviour of balloon‐expandable coronary stents. The dilation behaviour depends on both the materials properties and the design of the stent. A numerical simulation of the dilation process by means of FE is suitable. A comparison of the experimental measurement and the numerical simulation demonstrates, that a Cauchy stress‐strain material model should be used for numerical simulations. A local failure criterion is introduced, which considers void initiation as a criterion for mechanical failure. 相似文献
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Anticorrosion and cytocompatibility behavior of MAO/PLLA modified magnesium alloy WE42 总被引:1,自引:0,他引:1
Guo M Cao L Lu P Liu Y Xu X 《Journal of materials science. Materials in medicine》2011,22(7):1735-1740
Recently, biodegradable magnesium alloys have been introduced in the field of cardiovascular stents to avoid the specific
drawbacks of permanent metallic implants. However, the major obstacle of the clinical use of magnesium-based materials is
their rapid corrosion rate. In this paper, a composite micro-arc oxidation/poly-l-lactic acid (MAO/PLLA) coating was fabricated on the surface of the magnesium alloy WE42 to improve its corrosion resistance
and the cytocompatibility of the modified materials was also investigated for safety aim. In our study, the morphology of
materials was analyzed by Scanning electron microscopy. Potentiodynamic polarization was used to evaluate the corrosion behavior
of the samples and corrosion weight loss was used to demonstrate their degradation rate. Furthermore, we applied cytotoxicity
test in testing the cytocompatibility of the modified samples. The results showed that the PLLA coating effectively sealed
the microcracks and micropores on the surface of the MAO coating by physical interlocking to interfere the corrosion ions.
The corrosion rate was decreased and the cyototoxicity test showed that the MAO/PLLA composite coating WE42 had good cytocompatibility. 相似文献
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Silva RA Walls M Rondot B Da Cunha Belo M Guidoin R 《Journal of materials science. Materials in medicine》2002,13(5):495-500
The most popular coronary stents are made of 316L stainless steel and self-expandable Nitinol. Nevertheless, Ta has already been used to make stents for endovascular surgery and may constitute a good alternative to the other materials because of its higher corrosion resistance and radio-opacity property, which may facilitate the follow-up of stent catheterization. The characterization of Ta and its natural passive oxide films has been performed in a 0.15 M NaCl solution (simulated body fluid – SBF) using anodic polarizations, electrochemical impedance spectroscopy and photoelectrochemical techniques. Changes in microstructure have been observed by atomic force microscopy (AFM). Polarization curves show the existence of a current density increase between 1.40 and 1.80 V. Bode complex plots show that some perturbation of the film occurred in this potential interval which may be associated with a decrease in polarization resistance, Rp, indicating that the film may be less resistant to corrosive attack. Mott–Schottky capacity measurements show that the density of donors, Nd, varies with polarization. The optical band gap, E
g
, which is equal to 4.1 eV did not show variations in our experiments. The localized formation on the electrode surface, in the above potential interval of a Ta compound (possibly an oxide-hydroxide) was observed by AFM, and this may explain the appearance of the current density peak and capacity behavior at those potentials. 相似文献