新生儿出生体质量与孕期体质量指数变化的相关性

目的 探讨新生儿出生体质量与孕妇体质量指数变化的相关性.方法 选择2006年1月-2007年12月在我院产前检查并分娩且无内科并发症的孕妇1 000例,进行回顾性分析.分别测量并计算孕12周内、孕32周、分娩前孕妇身高和体质量、孕期体质量变化、孕期体质量指数变化,分析新生儿出生体质量与孕期体质量指数变化的相关性.结果 新生儿出生体质量与孕期体质量指数变化有正相关性.结论 孕期按孕周进行营养指导有利于减少围生期并发症,对胎儿生长受限者,应早于孕32周开始治疗,改善妊娠结局.     

妊娠期血脂水平对新生儿出生体质量影响的前瞻性队列研究

目的探讨妊娠期孕妇血脂水平与新生儿出生体质量、身长体质指数(QI指数)、巨大儿、大于胎龄儿(LGA)的关系。方法采用前瞻性队列研究的方法,以2017年6-7月于南京市妇幼保健院产科门诊建卡的1 664例孕妇建立研究队列,填写调查问卷采集孕妇的社会人口学特征,分别于孕中期(22～24周)和孕晚期(32～34周)监测血清总胆固醇(TC)、三酰甘油(TG)浓度,随访至分娩,记录分娩孕周、分娩方式、性别、出生体质量、身长、分娩期并发症等,分析孕期血脂水平和出生体质量、新生儿QI指数、巨大儿、LGA的相关性。结果孕期血脂水平较非孕期显著升高,孕中期高脂血症发生率为53. 6%,孕晚期高脂血症发生率达82. 6%,孕期TG浓度与新生儿出生体质量、QI指数呈正相关; TG升高组新生儿平均出生体质量、QI指数高于血脂正常组。多因素Logistic回归分析显示,孕晚期TG升高是巨大儿发生的独立危险因素,调整OR为1. 983(95%CI=1. 078～3. 646)。ROC曲线分析显示,使用孕晚期TG水平联合孕前BMI、孕周预测巨大儿的发生有一定的准确性,AUC=0. 762 (95%CI=0. 517～0. 802)。结论孕期高脂血症发生率高于非孕期,随着孕期进展血脂水平越高,孕期TG水平与出生体质量、QI指数呈正相关,TG水平增高导致巨大儿的发生率增加。     

1109例新生儿出生体重的影响因素

目的:了解新生儿出生体重的影响因素,为孕期保健提供科学依据。方法:回顾性分析2007年2月～2008年2月在厦门市妇幼保健院分娩的1109例糖代谢正常且无妊娠合并症孕妇的新生儿体重分布及影响因素。对孕妇年龄、身高、流产次数、孕周、孕前体重、孕中期增重、孕晚期增重、产前体质指数、子痫、贫血等进行单因素非条件Logistic逐步回归。同时从1109例中随机选取260例与同一时期分娩的252例糖代谢异常者进行分析。结果:产前低体质指数是低出生体重的危险因素(β0,OR1,P=0.000),中期增重过多、产前高体质指数是巨大儿的危险因素(β0,OR1,P=0.000;β0,OR1,P=0.006)。产前血糖控制情况不同,新生儿出生体重异常发生率有统计学差异(Fisher's=0.045)。结论:加强孕期管理,使孕期体重增长适度,避免发生早产的因素,及时、合理、有效地控制血糖,可能使新生儿体重控制在正常范围。     

孕期抑郁与早产的关系研究

目的探讨孕期抑郁是否增加早产、低出生体质量儿及小于胎龄儿等不良妊娠结局的风险,为孕期抑郁孕妇潜在的危险因素加以有效的干预提供参考。方法采用前瞻性队列研究设计,在深圳市南山区妇幼保健院招募单胎孕妇共1 377例进入统计分析。于孕中期(孕13～28周)使用爱丁堡产后抑郁筛查量表(EPDS)进行孕期抑郁症状的评估,评分≥12分作为孕期抑郁的诊断标准。通过深圳市妇幼保健系统查询并导出孕妇妊娠结局及相关人口学指标,运用多因素Logistic回归分析孕期抑郁与早产、低出生体质量等不良妊娠结局的关系。结果孕期抑郁的检出率为19.0%,正常组和孕期抑郁组的EPDS得分分别为6.5±2.9和13.8±2.0,差异有统计学意义(P0.05)。年龄≥35岁和户籍类型为深圳户籍的孕妇发生孕期抑郁的比例较低。在校正了孕妇年龄、教育程度、户籍类型、孕前体质指数(BMI)、二手烟、产次及胎儿性别等混杂因素后,孕期抑郁可显著增加早产的发生风险(OR=1.97; 95%CI:1.07～3.63),但与低出生体质量的关联在校正混杂因素后不再显著(OR=1.99; 95%CI:0.68～5.80)。本研究未发现孕期抑郁与小于胎龄儿、大于胎龄儿及巨大儿等有相关关系。分层分析中孕期抑郁与早产的关联在年龄35岁、非深圳户籍及胎儿性别为男性的孕妇中更为显著。结论孕期抑郁显著增加早产的发生风险,这一不利影响在年龄35岁、非深圳户籍及胎儿性别为男性的孕妇群体中更为明显。     

子痫前期孕妇分娩低出生体质量儿的相关影响因素及母婴结局

目的探讨子痫前期孕妇分娩低出生体质量儿的相关影响因素及母婴结局,改善围产结局。方法选取2014年1月-2017年12月厦门市妇幼保健院产科收治的268例住院子痫前期患者为研究对象,按照新生儿出生孕周及体质量,将新生儿分为早产低体质量组(118例)、足月低体质量组(36例)及对照组(114例,足月正常体质量组)。比较3组孕妇的一般特征、相关实验室检查结果、并发症发生情况及新生儿结局。结果 3组孕妇的年龄、分娩孕周、收缩压、舒张压、剖宫产率、肌酐、尿素氮、B/C、尿酸、24 h尿蛋白、血清白蛋白水平、子宫体炎发生率、1 min Apgar评分、轻度窒息、胎儿生长受限、胎儿窘迫发生率比较差异均有统计学意义(均P0. 05)。早产低体质量组与足月低体质量组孕妇的年龄、分娩孕周、收缩压、舒张压、24 h尿蛋白、血清白蛋白水平、子宫体炎发生率、1 min Apgar评分比较差异均有统计学意义(均P0. 05)。足月低体质量组与对照组孕妇的年龄、分娩孕周、尿素氮、B/C、胎儿生长受限发生率比较差异均有统计学意义(均P0. 05)。早产低体质量组与对照组孕妇的分娩孕周、收缩压、舒张压、剖宫产率、肌酐、尿素氮、B/C、尿酸、24 h尿蛋白、血清白蛋白水平、子宫体炎发生率、1 min Apgar评分、轻度窒息、胎儿生长受限、胎儿窘迫发生率比较差异均有统计学意义(均P0. 05)。结论子痫前期孕妇分娩低出生体质量儿的影响因素较多,低出生体质量对母儿都存在危害,尤其是新生儿,早产低出生体质量危害性更明显。     

孕期个体化营养指导对妊娠结局及新生儿出生体质量的影响

目的 探讨孕期个体化营养指导对妊娠结局及新生儿出生体质量的影响.方法 选择2011年6月至2012年6月于甘肃省妇幼保健院产科建卡、定期产检且住院分娩的300例单胎孕妇为研究对象,按照建卡时是否接受孕期个体化营养指导,将其分为研究组（n=150,孕期接受个体化营养指导）和对照组（n=150,孕期未接受个体化营养指导）.两组孕妇的年龄、孕前体质量、身高及孕前体质量指数（BMI）等一般临床资料比较,差异无统计学意义（P〉0.05）.比较分析两组孕妇的分娩方式、会阴侧切率、孕前BMI正常孕妇孕期体质量增长及新生儿出生体质量等（本研究遵循的程序符合甘肃省妇幼保健院伦理委员会制定的伦理学标准,得到该委员会批准,分组征得受试对象的知情同意,并与之签署临床研究知情同意书）.结果 研究组与对照组的分娩方式、孕前BMI正常孕妇孕期体质量增长、新生儿出生体质量比较,差异均有统计学意义（χ2=6.72,7.19,16.16,P〈0.05）.研究组与对照组的会阴侧切率比较（26.79% vs.29.67%）,差异无统计学意义（χ2=0.21,P〉0.05）.结论 孕期进行个体化营养指导有利于降低剖宫产率,控制孕期体质量增长及新生儿出生体质量于正常范围.     

胎儿生长受限149例临床分析

目的 探讨影响胎儿生长受限及国产儿结局的因素.方法 收集2011年1至12月于北京市海淀区妇幼保健院住院分娩的149例单胎胎儿生长受限孕产妇的临床资料,分析孕周、出生体重、产科合并症、分娩方式等与围产儿结局的关系.结果 发生胎儿生长受限的主要相关因素为孕期母体合并症;母体合并症组分娩孕周和新生儿出生体重均低于无母体合并症组,差异均有显著性差异(P值分别为0.002、0.001);胎儿窘迫率、新生儿窒息率与新生儿出生体重呈负相关(r值分别为-0.321,-0.403,均P＜0.05),孕周增加与新生儿体重增加之间呈正相关(r=0.875,P＜0.05);胎儿生长受限孕妇于孕36周之前分娩或大于孕40周后分娩的围产儿不良结局发生率较高;选择合适的分娩方式有利于改善围产儿结局.结论 对胎儿生长受限高危人群应进行筛查,早期诊断;对胎儿生长受限的孕妇应加强围产期保健、积极治疗母体合并症,适时终止妊娠、放宽剖宫产指征,改善围产儿结局.     

孕前体质指数和孕期增重与巨大儿发生率的相关性分析

目的分析孕前体质指数(BMI)和孕期增重与巨大儿发生率的相关性,为孕妇孕期体质量管理和新生儿体质量控制提供科学依据。方法选取2016年1月1日-12月31日在义乌市妇幼保健院产科分娩并具有完整产科资料的1 124名孕妇为研究对象,依据BMI将孕妇分为消瘦组(218名)、正常组(807名)、超重肥胖组(99名)。分析3组孕妇孕期增重和新生儿出生体质量、巨大儿发生率的关系,比较3组低出生体质量儿和巨大儿发生率。结果消瘦组、正常组孕妇孕期增重与新生儿出生体质量呈正相关(P0. 05);超重肥胖组孕妇孕期增重与新生儿出生体质量无相关性(P0. 05)。3组低出生体质量儿发生率比较差异无统计学意义(P0. 05),巨大儿发生率比较差异有统计学意义(P0. 05)。孕妇孕期增重百分位超过P85时,消瘦组和正常组巨大儿发生率明显增加,超重肥胖组巨大儿发生率无显著变化。结论孕期增重幅度与巨大儿发生率密切相关,因此合理控制孕期增重可有效降低巨大儿发生率。     

深圳市孕妇孕前体质指数、孕期增重对新生儿出生体格的影响

目的:探讨深圳市妇女孕前体质指数、孕期增重对新生儿出生体格的影响.方法:选取2013年4～7月在深圳市妇幼保健院进行常规产检的孕12周以内身体健康的孕妇作为研究对象,在孕早、中、晚期分别进行问卷调查、追踪监测其体重变化并收集孕妇分娩及婴儿出生情况等资料.结果:最终获得有效问卷421份,孕前消瘦组新生儿出生体重、身长均显著低于孕前体重正常及超重/肥胖组,差异有统计学意义(P＜0.01),其低出生体重发生率为4.8％,高于其他两组;孕前超重/肥胖组的巨大儿发生率为6.9％,高于孕前消瘦组的2.9％.将孕期增重划分为＜10 kg、10～ 15 kg、15～20 kg及＞20 kg 4组进行比较,孕期增重＜10 kg组新生儿出生身长显著低于其他组(P＜0.05),其低出生体重发生率为4.3％,高于其他各组;孕期增重＞20 kg组的巨大儿发生率为6.6％,高于孕期增重＜10 kg及10～ 15 kg组.多元线性回归分析结果显示,调整分娩孕周、怀孕次数及孕妇身高等因素后,孕前体质指数及孕期增重对新生儿出生体格有影响(P＜0.05).结论:孕前体质指数、孕期增重与新生儿出生体格关系密切,育龄妇女孕前应尽量达到正常体重标准,孕期保持适宜增重,确保胎儿正常发育.     

孕期运动模式与抑郁的队列研究

目的了解舟山地区孕妇孕期抑郁和运动现状,探讨孕期体育运动模式对孕期抑郁的影响,为推荐孕期适宜运动模式,促进孕妇身心健康提供理论依据。方法以2016年7月-2018年7月在舟山市妇幼保健院进行产检的孕妇作为队列研究对象,采用抑郁自评量表和自编孕期体力活动量表,分别在孕早、中和晚期进行问卷调查。结果孕妇在孕早、中和晚期抑郁症状的检出率分别为36. 22%、23. 91%和25. 41%。随着孕程进展,孕早、中和晚期一直运动率分别为12. 20%,9. 06%,8. 54%。多因素Logistic回归模型分析显示孕前运动模式与孕妇孕中、晚期抑郁负相关(OR=0. 648、OR=0. 686)。全孕期运动模式和孕妇在孕早、中、晚期抑郁均负相关(OR=0. 502、OR=0. 455和OR=0. 480)。结论舟山地区孕妇在各孕期抑郁发生率较高,尤其要关注孕早期的抑郁和体力活动变化情况,孕前和全孕程的体育活动模式是孕妇孕期健康心理的保护因素,应在孕妇保健中制定相关干预措施。     

广西平果县和德保县壮族人群低出生体重的影响因素研究

目的 分析壮族人群低出生体重发生情况,探讨低出生体重儿的影响因素。方法 选取在广西平果县人民医院、妇幼保健院及德保县妇幼保健院2012年1月1日~2015年6月1日出生的4 915例壮族活产新生儿为研究对象,收集一般人口学资料及低出生体重相关的影响因素,采用多因素Logistic回归方法分析低出生体重儿的影响因素。结果 低出生体重儿358例,低出生体重率为7.28%。母亲孕龄≥35岁（OR=1.72）、身高150 cm以下（OR=2.75）、孕早期体质指数（body mass index,BMI）<18.5 kg/m2（OR=1.68）、血红蛋白浓度<110 g/L（OR=1.50）、孕中期增重少（OR=1.57）、流产史（OR=1.76）、妊娠期高压（OR =5.32）、多产次（OR=1.51）、孕期产前检查少于8次（OR=2.10）等为低出生体重儿发生的危险因素;母亲孕早期BMI≥24.0 kg/m2（OR=0.26）、分娩孕周37周及以上（OR =0.06）、单胎（OR=0.04）等为保护因素。结论 母亲孕龄、身高、孕早期BMI、血红蛋白浓度、流产史、妊娠期高血压、孕期产前检查次数等是壮族人群低出生体重的影响因素,应采取综合措施预防和减少低出生体重儿的发生。     

The influence of age at exposure to PBBs on birth outcomes

The determination of critical windows of susceptibility to environmental chemical exposures and health has become a major public health focus. This study examined the association between early age at exposure to polybrominated biphenyls (PBBs) and subsequent birth weight and gestational length in offspring among females. The study population consisted of 1111 births that occurred among 560 women enrolled in the Michigan PBB Cohort from 1975 to 1994. Maternal age at exposure was categorized into three groups:<10 years (n = 64), 11-16 years (n = 149), and 17-42 years (n = 347). Overall serum PBB levels ranged from 0 to 1490 ppb, with a median of 2, 3, and 2 ppb in the three age groups, respectively. Separate mixed-effects linear regression models were used to evaluate the effect of age at exposure (years) and initial PBB level (ppb) on birth weight (grams) and gestational age (weeks), controlling for gestational age (weeks) (in the model examining effects on birth weight), BMI (kg/m(2)) and serum PCB level at enrollment (ppb), maternal age and paternal education at delivery, parity, infant gender, interval between the initial serum test and date of delivery (years), and the trimester in which prenatal care was initiated. Relative to the oldest age group, age<10 years at exposure was the most important predictor of increased birth weight (estimated regression coefficient = 225 g, P = 0.012). Infant birth weight increased approximately 16 g for every 10 ppb increase in serum PBBs (P=0.004). There was no association between initial PBB levels and gestational age, nor were initial serum PCB levels associated with either infant birth weight or gestational length. These results provide support for the hypothesis that early age at exposure may be an important determinant in subsequent health effects due to environmental chemical exposures.     

孕育史对孕期抑郁影响的前瞻性队列研究

  目的   探究孕育史对妊娠各期抑郁发生的影响。   方法   使用中国孕产妇队列研究·协和项目中孕育史与妊娠各期抑郁数据完整的3 792名孕妇进行研究。采用爱丁堡产后抑郁量表测量孕妇的抑郁状况。采用χ2检验进行单因素分析, 采用Log-binomial回归模型进行多因素分析, 计算调整相对危险度(relative risk, RR)值及其95%可信区间(confidence interval, CI), 并用森林图进行展示。   结果   Log-binomial回归结果显示, 分娩史增加孕妇孕中期抑郁(RR:1.04, 95% CI:1.01~1.08, P=0.042)和孕晚期抑郁(RR:1.05, 95% CI:1.01~1.10, P=0.020)的发生风险; 与无剖宫产史的孕妇相比, 有剖宫产史的孕妇孕晚期抑郁风险增加了6%(RR:1.06, 95% CI:1.01~1.11, P=0.041)。   结论   孕育史对妊娠抑郁的发生有重要影响, 妇幼保健人员应重点关注此类孕妇, 并开展针对性的健康宣教和心理护理, 加强对孕妇情绪变化的观察并及时给予心理调整。     

Timing of Incarceration During Pregnancy and Birth Outcomes: Exploring Racial Differences

Objectives To examine whether there are racial differences in the relation between the timing of incarceration during pregnancy and birth outcomes among incarcerated pregnant women. Methods We examined the medical records associated with 360 infants born to pregnant inmates in Texas state prisons between January 1, 2002 and December 31, 2004. Weighted linear regression was used, within racial strata, to model gestational age at delivery, and infant birth weight, respectively, as functions of gestational age at maternal admission to prison. Models were adjusted for maternal age; gravidity; educational attainment; history of tobacco, substance, and alcohol use and the presence of any maternal chronic disease. Results Among Whites there was a 360.8 g lower mean birth weight for infants born to women incarcerated during weeks 14–20 relative to infants born to women incarcerated during weeks 1–13 (p < 0.10). Among Blacks and Hispanics, incarceration after the first trimester was not associated with a significant decrease in infant birth weight relative to incarceration during the first trimester. White women entering prison during the first trimester delivered infants at higher gestational ages than White women entering in the second trimester but the opposite was the case for Hispanics. Conclusions The association between the quantity of exposure to prison during pregnancy and birth outcomes appears to be different for Blacks, Whites, and Hispanic women. Future studies of the effect of incarceration on pregnancy outcomes should attempt to uncover potential racial differences in trends by obtaining racially stratified results or by assessing interaction with race.     

Trimester of Maternal Gestational Weight Gain and Offspring Body Weight at Birth and Age Five

To investigate associations of trimester-specific GWG with fetal birth size and BMI at age 5?years. We examined 3,015 singleton births to women without pregnancy complications from the Child Health and Development Studies prospective cohort with measured weights during pregnancy. We used multivariable regression to examine the associations between total and trimester gestational weight gain (GWG) and birth weight for gestational age and child BMI outcomes, adjusting for maternal age, race/ethnicity, education, marital status, parity, pre-pregnancy body mass index (BMI), and smoking; paternal overweight, gestational age, and infant sex. We explored differences in associations by maternal BMI and infant sex. GWG in all trimesters was significantly and independently associated with birth weight with associations stronger, though not significantly, in the second trimester. First trimester GWG was associated with child BMI outcomes (OR for child overweight?=?1.05; 95% CI?=?1.02, 1.09). Each kg of first trimester GWG was significantly associated with increased child BMI z-score in women of low (???=?0.099; 95% CI?=?0.034, 0.163) and normal (???=?0.028; 95% CI?=?0.012, 0.044), but not high pre-pregnancy BMI. GWG in all trimesters was associated with birth weight; only first trimester GWG was associated with child BMI. If replicated, this information could help specify recommendations for maternal GWG and elucidate mechanisms connecting GWG to child BMI.     

Maternal Dietary Selenium Intake during Pregnancy Is Associated with Higher Birth Weight and Lower Risk of Small for Gestational Age Births in the Norwegian Mother,Father and Child Cohort Study

Selenium is an essential trace element involved in the body’s redox reactions. Low selenium intake during pregnancy has been associated with low birth weight and an increased risk of children being born small for gestational age (SGA). Based on data from the Norwegian Mother, Father and Child Cohort Study (MoBa) and the Medical Birth Registry of Norway (MBRN), we studied the association of maternal selenium intake from diet and supplements during the first half of pregnancy (n = 71,728 women) and selenium status in mid-pregnancy (n = 2628 women) with birth weight and SGA status, according to population-based, ultrasound-based and customized growth standards. An increase of one standard deviation of maternal dietary selenium intake was associated with increased birth weight z-scores (ß = 0.027, 95% CI: 0.007, 0.041) and lower SGA risk (OR = 0.91, 95% CI 0.86, 0.97) after adjusting for confounders. Maternal organic and inorganic selenium intake from supplements as well as whole blood selenium concentration were not associated with birth weight or SGA. Our results suggest that a maternal diet rich in selenium during pregnancy may be beneficial for foetal growth. However, the effect estimates were small and further studies are needed to elucidate the potential impact of selenium on foetal growth.     

Anaemia in the first but not in the second or third trimester is a risk factor for low birth weight

OBJECTIVE: To assess pregnancy outcome in women with anaemia during pregnancy. METHODS: The study design involved a retrospective chart review of all women registering for prenatal care in the area of Kuopio University Hospital between 1990 and 2000. A haemoglobin concentration below 100g/l was used as a cutoff for anaemia and affected women (N=597) were stratified by the trimester at which anaemia was diagnosed. Multiple regression analysis was used to compare obstetric outcomes in the study groups and in non-anaemic women (N=22,202). RESULTS: The frequency of anaemia was 2.6%, with 0.3% occurring in the first trimester. After controlling for confounding factors, anaemia detected in the first trimester was associated with low-birth-weight infants (OR=3.14, 95% CI: 1.35-7.28) whereas the mid- and third-trimester anaemia groups showed no significantly different outcomes when compared with the non-anaemic women. First trimester anaemia was not significantly associated with small birth weight for gestational age (OR=0.98, 95% CI: 0.41-2.17) or with premature delivery <37 weeks (OR=1.80, 95% CI: 0.72-4.49). CONCLUSIONS: Maternal anaemia detected in the first trimester is associated with low birth weight.     

Perinatal Depression and Birth Outcomes in a Healthy Start Project

Given the risk of adverse perinatal outcomes associated with a depressive disorder, the Health Resources and Services Administration’s (HRSA) Maternal and Child Health Bureau (MCHB) from 2001–2005 devoted resources through the Federal Healthy Start Initiative to screen pregnant women for depression and link them with services. In this report, we present the evaluation of a program that screened for depression and provided services for women with depressive symptoms or psychiatric distress in pregnancy to assess whether the program was associated with a reduction in babies born low birth weight, small for gestational age, or preterm. The program impact was examined among 1,100 women in three cohorts enrolled from 2001–2005 that included: (1) subjects recruited prior to the inception of the Healthy Start Initiative; (2) subjects enrolled in the Healthy Start Initiative; and (3) a comparison group recruited during the project period but not enrolled in the Healthy Start Initiative. After adjustment for covariates, women with probable depression were over one and a half times more likely to give birth to a preterm baby than non depressed women. Neither adjusted nor unadjusted risks for delivery of preterm, low birth weight or small for gestational age infants were significantly lower for women enrolled in Healthy Start as compared to women not enrolled in Healthy Start. However, regardless of enrollment in Healthy Start, women who delivered babies after the Healthy Start program began were 85% less likely to deliver preterm babies than women giving birth before the program began. Depression status conferred increased risk of adverse birth outcomes, results that were not altered by participation in the Healthy Start program. We cannot exclude the possibility that the community activities of the Healthy Start program promoted increased attention to health issues among depressed women and hence enhance birth outcomes.     

1998～2007年住院分娩活产儿出生体重变化

目的:了解10年住院分娩活产儿出生体重变化。方法:回顾性分析该院1998~2007年住院分娩(孕周≥28周)活产儿出生体重,对出生体重变化及相关因素进行分析。结果:10年活产儿平均出生体重(3 143±496)g,年度间差异无统计学意义(F=1.796 3,P=0.064)。各个月份之间出生体重差异有统计学意义(F=2.425,P=0.005)。男婴、女婴体重差异有统计学意义(t=12.621,P<0.001)。孕周间出生体重差异有统计学意义(F=628.105,P<0.001),孕周与体重呈显著正相关(Pearson系数r=0.578,P<0.001)。不同孕次间出生体重差异有统计学意义(F=10.613,P<0.001)。不同产次的活产儿出生体重的差异有统计学意义(F=8.739,P<0.001)。妊娠胎数与出生体重呈负相关(r=-0.285,P<0.001)。产妇年龄与出生体重呈轻度正相关(r=0.043,P<0.001)。年度间巨大儿构成比的差异无统计学意义(2χ=4.392,P=0.884);低体重儿构成比的差异有统计学意义(2χ=23.229,P=0.006),有上升趋势(2χ=15.111,P<0.001);未足月低体重儿构成比呈上升趋势(2χ=0.207,P=0.649)。结论:各年度活产儿出生体重总体无差异;出生体重与分娩月份、胎儿性别、孕周、胎数及产妇孕产次、年龄有关。10年间巨大儿构成比无增加趋势,低体重儿构成比有逐年增加趋势,其中未足月低体重儿构成比逐年明显增加。     

Depression During Pregnancy and Adverse Birth Outcomes Among Predominantly Puerto Rican Women

Maternal and Child Health Journal - Objectives To examine associations between depression and preterm birth and small-for gestational age (SGA) among women of predominantly Puerto Rican descent, a...