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6-氟-7(4-甲基-1-哌嗪基)-8-氨基-4-氧代-1,4-二氢喹啉-3-羧酸乙酯(5A)和脂肪酸在PPA中缩合,得2-烃基-6-氧代-8-氟-9-(4-甲基-1-哌嗪基)-6H-咪唑并(4,5,1-ij)喹啉-5-羟酸(2Ab-2Ae),6-氟-7-含氮杂环-8-氨基-4-氧代-1,4-二氢-3-喹啉羧酸(9A-9D)与各种酸在PPA中缩合或与原甲酸三乙酯缩合或经重氮化反应,可分别得到其它目的物2Af-2Ah,2Bc,2Cc,2Aa-2Da,2Bi和2Ci。体外抗菌筛选证明仅化合物2Ab和2Ac具有中等程度的抗菌作用。 相似文献
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替米沙坦的合成工艺改进 总被引:2,自引:0,他引:2
以3—甲基—4—氨基苯甲酸甲酯为起始原料,经酰化、硝化、还原、环合、水解得4—甲基—2—正丙基—6—甲氧羰基苯并咪唑,在多聚磷酸的作用下,与N—甲基邻苯二胺缩合,生成的产物再与4’—溴甲基联苯—2—甲酸甲酯缩合、水解得替米沙坦,总收率为15.7%。 相似文献
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对氟苯甲醚与马来酸酐缩合、碱性闭环得到(±)-6-氟-3,4-二氢-4-氧代-2H-1-苯并吡喃-2-羧酸,和氯化亚砜反应得到的酰氯与(S)-(-)-1-苯乙胺缩合,得到的酰胺差向异构体混合物利用乙醇重结晶拆分并水解得到单一对映体(2S)-6-氟-3,4-二氢-4-氧代-2H-1-苯并吡喃-2-羧酸,再经闭环、酯化、氨解等反应得到非达司他,总收率21%. 相似文献
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对甲苯胺经酰化、缩合、Smiles重排和水解得到的N-(2-氯-6-氟苯基)对甲苯胺,经酰化反应、闭环、还原和水解等反应制得罗美昔布,总收率接近40%。 相似文献
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建立了抗肿瘤肽AP-9的Fmoc固相全合成方法,产品纯度大于98%。着重研究了Fmoc-Arg(Pbf)-OH与H—Pro—Trt树脂的缩合反应。结果表明,以THF-NMP(1:1)为溶剂,于30℃微波辐射反应6min,缩合产率达80.2%。 相似文献
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The condensation of 2-methyl-3-amino-4(3H)-quinazolinone and 2-phenyl-3-amino-4(3H)-quinazolinone with different aldehydes is described. Reacting equimolecular amounts of these two amino compounds with p-nitrobenzaldehyde, p-hydroxybenzaldehyde, cinnamaldehyde and 5-nitro-2-furfuraldehyde diacetate afforded the respective Schiff's bases. Condensation of benzaldehyde, anisaldehyde, p-dimethylaminobenzaldehyde and o-nitrobenzaldehyde with the former quinazolinone afforded the corresponding condensation products while with the latter no condensation took place. Furthermore, condensation of cinnamaldehyde with methylaminoquinazolinone in pyridine and in glacial acetic acid afforded the mono- and di-condensation products respectively while furfural, thiophenaldehyde, resorcinaldehyde, protocatechualdehyde, veratraldehyde, and salicylaldehyde, the condensation ended in failure. 相似文献
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司帕沙星的合成工艺研究 总被引:5,自引:1,他引:4
由2,3,4,5-四氟苯四酸为原料,经硝化,酰氯化,与丙二酸二乙酯缩合,再部分水解并脱羧,然后与原甲酸三乙酯缩合,环丙胺置换,环合,硝基还原,水解后与顺式-2,6-二甲基哌嗪缩合得到司帕沙星,总收率约28%。 相似文献
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地红霉素的合成 总被引:2,自引:0,他引:2
梁毅恒 《中国医药工业杂志》2002,33(6):269-270
以红老先生继起始原料,经与水合肼缩合,硼氢化钠还原,然后与甲氧基乙氧基乙醛缩合,制得地红霉素,总收率26.5%。 相似文献
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奥氮平的合成 总被引:4,自引:1,他引:3
岑均达 《中国医药工业杂志》2001,32(9):391-393
以丙二腈,丙醛,硫化原料在三乙胺存在下缩合制得2-氨基-3-氰基-5-甲基噻吩,再与邻氯硝基苯缩合制得2-(邻硝基苯胺基)-3-氰基-5-甲基噻吩,用氯化亚锡还原合环合制得2-甲基-4-氨基-10H-噻吩并[2,3-b][1,5]苯二氮杂Chuo,最后与哌嗪缩合并甲基化制得奥氮平,总收率29%。 相似文献
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Karydis S Asimakopoulos B Papadopoulos N Vakalopoulos I Al-Hasani S Nikolettos N 《In vivo (Athens, Greece)》2005,19(5):921-925
BACKGROUND: The condensation of sperm chromatin during spermiogenesis and epididymal transport is of essential importance for fertilization. The main purpose of this study was to examine whether abnormalities of sperm nuclear condensation can influence the outcome of intracytoplasmic sperm injection (ICSI) cycles. MATERIALS AND METHODS: Semen samples from 154 ICSI cycles were studied. Before semen preparation for ICSI, basic semen analysis was performed and a small portion from each sample was fixed. The condensation of sperm nuclear chromatin was evaluated with chromomycin A3 under a fluorescence microscope. RESULTS: The incidence of spermatozoa with abnormal chromatin condensation was positively correlated with sperm concentration (p = 0.020565), but was not correlated with other semen parameters such as morphology and motility. Abnormal chromatin condensation was also not correlated with fertilization rate, cumulative embryo score or pregnancy rate. CONCLUSION: The above results indicate that ICSI outcome is not influenced by the incidence of spermatozoa with abnormal chromatin condensation. 相似文献
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左旋氧氟沙星不对称合成工艺的研究 总被引:6,自引:0,他引:6
以2,3,4,5-四氟苯甲酸为原料,经酰氯化后与丙二酸二乙酯缩合、部分水解脱羧并与原甲酸三乙酯缩合、S-( )-2-氨基丙醇置换、环合、水解后与4-甲基哌嗪缩合制得左旋氧氟沙星,总收率为39.2%,本合成工艺操作简便、收率高、光学纯度好,是一条较好的不对称合成左旋氧氟沙星的方法。 相似文献