腹壁肿瘤切除术后遗留腹壁巨大缺损39例修复与重建

目的探讨采用聚丙烯（Polypropylene,PP）补片或复合补片修复腹壁肿瘤切除术后遗留腹壁巨大缺损的方法和效果。方法收治的39例腹壁巨大肿瘤患者均采取了手术切除治疗。采用直接缝合腹膜关闭腹腔,并在腹膜外用PP补片修复缺损6例,采用带蒂大网膜加PP补片修复缺损19例,采用复合补片修补腹壁缺损14例。结果 39例中因术后发生急性心肌梗塞死亡1例。术后肺部感染1例,经抗感染治疗治愈。术后出现皮下积液5例,经穿刺抽吸,理疗和引流等措施治愈。随访34例,随访时间1～5年。在访的4例结肠癌患者和4例胃癌患者术后12～27个月均因肿瘤腹腔内复发及肝脏广泛转移死亡,术后肿瘤局部复发1例,随访的全部患者未发生腹壁切口疝和肠梗阻等并发症。结论采用PP补片或复合补片修复腹壁肿瘤切除后遗留腹壁巨大缺损并发症发生率低,效果良好。     

Proceed补片对腹壁硬纤维瘤切除后遗留巨大腹壁缺损修补的疗效分析

目的探讨Proceed网片对腹壁缺损修补的疗效。方法回顾性分析了我院2年来对15例硬纤维瘤患者以Proceed补片进行腹壁缺损修补的手术方法及随访资料。结果术后3例发生皮下积液,全部患者随访1个月~2年,无感染、切口疝发生,无局部不适。结论Proceed补片具有抗粘连、复发率低等优点,可在腹壁硬纤维瘤切除术后遗留巨大腹壁缺损修补中加以应用。     

生物型硬脑膜补片修补大鼠全层腹壁缺损

目的 探讨运用生物型硬脑膜补片修补大鼠全层腹壁缺损的可行性,并与涤纶布补片修补比较.方法 分别采用脑膜建补片和涤纶布修补12对大鼠全层腹壁缺损,术后2、8、16周分批处死大鼠采集标本,观察创面感染情况、缺损愈合速度、缺损愈合组织的厚度、镜下病理情况.结果 脑膜建补片组大鼠无死亡,12例缺损全部修复成功.涤纶组大鼠死亡2例,10例缺损修复愈合.脑膜建补片组织愈合较快,镜下炎症反应较轻,但愈合组织厚度差异无统计学意义.结论 脑膜建补片能很好地诱导结缔组织增生,修复腹壁缺损.     

基于大网膜瓣三明治桥接技术修复巨大腹壁缺损23例疗效分析

目的 探讨基于大网膜瓣的生物补片-带蒂大网膜瓣-合成补片三明治（BOSS）桥接技术修复巨大腹壁缺损的手术方案并分析疗效。方法 回顾性分析2016年1月至2020年12月上海交通大学医学院附属第九人民医院收治的23例巨大腹壁缺损病人临床资料，分析BOSS桥接技术修复巨大腹壁缺损的临床效果及可行性。结果 所有病人均顺利完成手术。腹壁缺损面积为（422.2±334.1）cm2，术中出血量为（450.0±420.0）mL，手术时间为（205.8±80.9）min。术后随访（24.4±17.4）个月，疝复发或补片膨出发生率为4.3%，切口并发症发生率为13.0%。结论 采用BOSS桥接技术修复巨大腹壁缺损可显著改善腹壁修复重建效果。     

无张力修补在腹壁穿刺孔癌种植转移灶切除中的应用

目的探讨疝补片在修补腹壁穿刺孔癌种植转移灶切除腹壁缺损的效果。方法对2000年1月-2007年12月我院收治30例腹壁穿刺孔癌种植灶患者采用手术切除及巴德补片修补腹壁缺损的临床资料进行回顾性分析。结果30例患者术后伤口均获得一期愈合。随访时间一年，无局部肿瘤复发，亦无切口疝发生。结论利用巴德补片修复腹壁穿刺孔癌种植转移灶切除术后的腹壁缺损，是减少肿瘤局部复发和预防腹壁切口疝的好方法，值得在临床上推广应用。     

腹壁韧带样纤维瘤的术后腹壁重建的治疗研究

目的探讨人工补片在韧带样纤维瘤病术后腹壁重建中的临床疗效。 方法回顾性分析2012年2月至2016年2月,首都医科大学附属北京朝阳医院收治的11例腹壁韧带样纤维瘤病患者的临床资料,所有患者行根治性手术,术后腹壁缺损使用人工补片行腹壁重建,分析其临床疗效。 结果所有患者均使用人工补片行腹壁重建,平均手术时间（97±33）min,平均住院时间（19.2±3.1）d,所有患者术后恢复良好,伤口Ⅰ期愈合,无伤口感染及局部异物感,无死亡患者,出现皮下积液者1例,经穿刺抽吸后治愈。随访时间7～60个月,平均随访时间（31.8±18.5）个月,肿瘤复发1例,无死亡患者,无补片感染、慢性疼痛及局部异物感等补片相关并发症,无肠梗阻及切口疝发生。 结论人工补片用于腹壁重建具有良好的临床疗效。     

生长因子覆膜纳米纤维疝补片的制备及修补大鼠腹壁缺损的实验研究

目的探究生长因子覆膜纳米纤维疝补片对大鼠腹壁缺损修复的作用。 方法利用静电纺丝技术制备生长因子VEGF165及FGF-21覆膜纳米纤维疝补片。选取30只SD大鼠,体质量100～120 g,手术造成1 cm×1 cm的全层腹壁缺损,随机分成2组,每组15只,分别采用生长因子覆膜纳米纤维疝补片（实验组）和聚丙烯疝补片（对照组）修补。术后1、2、4周分批取材（每时间点5只）对动物一般情况观察、手术部位血清肿形成情况检测、组织学观察及炎性因子表达情况比较。 结果成功制备生长因子VEGF165及FGF-21覆膜纳米纤维疝补片;术后2组大鼠均健康成活,未发生疝瘘等不良反应,缺损得到完整修复。2组大鼠在手术部位血清肿形成方面差异无统计学意义（P>0.05）。实验组巨噬细胞及异物巨细胞计数在术后1、2周低于对照组（56.3±7.3 vs 75.2±9.6,P<0.01;37.1±6.9 vs 53.7±8.1,P<0.05）,在术后4周,2组间差异无统计学意义（P>0.05）。HE染色观察表明实验组手术部位的腹壁组织的炎症反应低于对照组。实验组手术部位腹壁组织TNF-α及IL-6 mRNA表达均明显低于对照组,差异均无统计学意义（63.67±5.10 vs 194.43± 25.39,P<0.01;84.24±8.22 vs 171.41±15.86,P<0.01）。 结论生长因子覆膜纳米纤维疝补片具有良好的生物相容性,且能降低手术部位的炎症反应,值得进一步研究。     

恶性肿瘤切除后巨大腹壁缺损的修复

目的 探讨原发于腹壁或侵犯腹壁的恶性肿瘤切除术后巨大腹壁缺损的修复方法 .方法 本组20例,腹壁恶性肿瘤12例,其中腹壁横纹肌肉瘤9例、恶性纤维组织细胞瘤3例;腹膜后及腹腔恶性肿瘤侵犯腹壁8例,其中腹膜后恶性肿瘤3例、横结肠癌1例、升结肠癌右半结肠切除术后2～3年局部复发3例、肾癌术后5年腹壁种植复发1例.采用自膨式聚丙烯和膨化聚四氟乙烯复合补片行修复手术.观察术后并发症、修复成功率.结果 术后一期愈合20例,无皮下积液,无切口感染、裂开和切口疝发生,未见修补材料与肠管粘连,修复成功率100%.随访20例,随访时间6～18个月,平均随访(9.3±3.4)个月.补片与腹壁相容性良好,无局部炎症反应;均未发现材料与肠管粘连,无切口疝形成,腹壁修补区未见肿瘤复发.结论 自膨式聚丙烯和膨化聚四氟乙烯复合补片具有抗张力强度大、良好的组织相容性、修补术后并发症少等特点,是一种良好的肿瘤切除后腹壁缺损修复材料.     

根治切除联合人工材料桥接治疗腹壁型侵袭性纤维瘤病16例报告

背景与目的 侵袭性纤维瘤病（AF）是一种临床较为罕见的交界性肿瘤，一般不具备远处转移能力，具有局部侵袭特性，复发率较高。对于腹壁型AF而言，根治性切除意味着腹壁完整性的破坏，切除肿瘤后的腹壁重建处理较为棘手。本研究探讨根治切除联合人工材料桥接治疗腹壁型AF的安全性和疗效。方法 回顾性分析2013年1月—2021年10月中南大学湘雅二医院普外老年外科收治的16例腹壁型AF患者的临床及随访资料。所有患者均行腹壁病灶一期根治性切除，并同期采用人工材料桥接的方式修复腹壁缺损。结果 16例患者平均手术时间98（70~235）min，肿瘤平均长径8.6（4~14）cm，肿瘤切除后腹壁缺损6 cm×8 cm~14 cm×19 cm。腹壁缺损采用人工材料修复重建，6例采用sublay桥接，9例采用腹膜内补片桥接，1例紧贴耻骨病例采用立体桥接。所有手术均顺利完成。术后病理报告均为AF，其中唯一男性患者检测到CMNNB1基因外显子3（T41A）突变。1例患者出现术后血清肿，开放伤口后行封闭负压辅助闭合技术（VAC）治疗，行二期缝合后治愈。余15例患者无伤口感染、补片感染、肠梗阻等严重术后并发症，伤口甲级愈合出院。中位随访46（12~110）个月，随访率100%，未见肿瘤复发，无慢性疼痛、补片感染、补片膨出及切口疝发生。结论 腹壁型AF可发生于腹壁肌层的不同部位，以局部包块为主要表现，手术是主要治疗方式。完整切除肿瘤和保证阴性切缘可以有效避免肿瘤的复发，根治切除手术前应充分评估肿瘤大小、侵犯层面、缺损部位及范围，设计个体化手术方式，可有效达到腹壁形态和功能的重建。根治切除联合人工材料桥接修复切除后腹壁缺损治疗腹壁型AF安全有效。     

腹壁切口疝修补术后腹壁膨出相关因素研究

目的探讨腹壁切口疝术后腹壁膨出（bulging）及复发的发生率及其相关危险因素。 方法回顾性分析2008年1月至2017年12月,复旦大学附属华东医院行腹壁切口疝修补术治疗的774例患者临床资料,观察腹壁膨出及疝复发的发生率与临床病例因素的关系。 结果术后平均住院时间（8.15±2.60）d,随访时间3～78个月。术后腹壁膨出58例（7.49%）,患者体质量指数（BMI）、是否急诊手术、是否使用补片、补片放置层次、手术入路、是否关闭腹壁缺损等与腹壁切口疝修补术后腹壁膨出有关。 结论影响腹壁切口疝术后腹壁膨出发生的独立危险因素为BMI、是否急诊手术、是否使用补片、补片放置的层次、手术入路、是否关闭腹壁缺损。临床应加强术前病例的筛选,减少急诊手术的同时,严格控制患者体重,选择合适的手术方式和植入修补、确实关闭腹壁缺损,并加强术后切口管理,以预防和减少腹壁切口疝术后腹壁膨出的发生。     

Perineal hernia as a rare complication after laparoscopic abdominoperineal resection: Report of a case

We report what seems to be the second documented case of perineal hernia after laparoscopic abdominoperineal resection (APR) and describe its successful repair with transperineal intraperitoneal mesh. An 89-year-old woman complained of a large, painful perineal swelling 4 months after APR for rectal cancer. Computed tomography (CT) showed small intestine protruding through the pelvic floor into the perineal area. However, opening of the hernia sac revealed no intra-abdominal adhesions. An oval, 8 × 12 cm Bard Composix Kugel Patch (Davol, Cranston, RI, USA) was inserted into the intraperitoneal space and secured over the defect in the pelvic floor; then firmly attached to the pelvic wall with 16 interrupted nonabsorbable sutures. There has been no sign of hernia recurrence in 10 months of follow-up. We speculate that because laparoscopic surgery is minimally invasive, fewer postoperative adhesions in the abdominal cavity can result in the small bowel sliding more readily into the perineal area. Based on our experience, perineal hernia after laparoscopic APR can be repaired easily and effectively with a Composix Kugel Patch.     

Laparoscopic treatment of abdominal wall hernias: prosthesis material comparison

Hernia is due to abdominal wall weakening. This allows the contents of the abdomen to protrude from normal boundaries. Hernias are repaired by implanting a sterile surgical mesh to strengthen the weakened abdominal wall. Aim of this study is to compare the results obtained by bard Composix? L/P mesh or Dualmesh Plus Gore? implanting. The mesh has various beneficial characteristics. It is a reinforcing material for the abdominal wall, even when in the direct contact with the intestinal tract does not cause adhsion problems. The use of biocompatible materials is necessary in laparoscopic hernia repair. e-PTFE prosthesis and Dual Mesh? were the first to be used for laparoscopic treatment of the abdominal wall defects. These prosthesis are the result of many improvements, actually they are 1-mm thick and the two surfaces have different characteristics. Compound meshes are composed by e-PTFE and polypropylene with different percentage of the two materials and methods of interactions. The incidence of early complications were poor in relation to both types of implants, only seroma cases e-PTFE treated showed a prevalence of complication, in agreement with literature. About relapses in our experience we found that e-PTFE cases were predominantly. Dual Mesh? has better adaptability than Bard Composix?, which allows easier placement of the prosthesis as well as a better adaptation to the wall surface. The Bard Composix?, thanks to rigidity due to the polypropylene component has better handling than the Dual Mesh?, as it promotes a rapid and easy deployment of the prosthesis inside the abdominal cavity, favoring its positioning. The use of both prosthesis depends also on the experience specific to each operator, moreover, a rigorous surgical technique remains fundamental for the application of the mesh used.     

腹壁肿瘤切除术后巨大/超大腹壁缺损的外科修复重建策略

腹壁肿瘤、尤其是恶性肿瘤R0切除术后会导致巨大、甚至超大腹壁缺损,选择合理的腹壁修复重建技术是治疗关键。本文总结了腹壁恶性肿瘤的临床特点、治疗现状、肿瘤扩大切除后腹壁缺损的术前评估和腹壁缺损修复重建的术式选择;重点阐释了腹壁缺损类型、缺损大小、缺损周围组织情况和患者全身情况对术式选择的重要性。     

A defect of the abdominal wall with intestinal fistulas after the repair of incisional hernia using Composix Kugel Patch

INTRODUCTIONIn the present paper, we show a rare case of the large abdominal wall defect and enterocutaneous fistulas after the tension free repair using prostheses for incisional hernia.PRESENTATION OF CASEThe patient, a 70-year-old man, had a history of a hemicolectomy for a perforating colon cancer, complicated by a large incisional hernia that was closed primarily but recurred. Three years later, the hernia was repaired at the time of a second colectomy using a Composix Kugel Patch. His course was complicated by a chronic postoperative wound infection with eventual development of enterocutaneous fistulas. The patient was successfully treated with extirpation of the prosthesis, resection of the fistulized bowel, and placement of a tensor fasciae latae myocutaneous flap.DISCUSSIONEnterocutaneous fistulas are a known complication of incisional hernia repairs using prostheses. Additional clinical data are required to confirm the safety and efficacy of this procedure as it becomes more widely adopted.CONCLUSIONExtirpation of the prosthesis should be performed without delay to prevent serious complications. Reconstruction with a tensor fasciae latae myocutaneous flap was useful for the large abdominal wall defect.     

Resistance to adhesion formation: A comparative study of treated and untreated mesh products placed in the abdominal cavity

Background: New materials have been devised to prevent postoperative adhesions when placing a prosthesis in contact with abdominal contents. Methods: Eighty rats underwent laparotomy and denudation of the serosa of the cecum and peritoneal covering of the abdominal wall. Five treated mesh products (Parietex Composite, Parietene Composite, Bard Composix E/X, Sepramesh, and Gore-Tex Dual Mesh) and one untreated mesh product (untreated Parietene) were randomly placed between the cecum and abdominal wall. A group without mesh was used as control. The animals were sacrificed at 21 days following surgery and analyzed for the presence of adhesions.Results: The incidence of adhesion formation, mean adhesion area, maximum adhesion length, and strength of adhesion separation were similar between Parietex Composite, Parietene Composite, and Bard Composix E/X, and they were significantly less than with Sepramesh, untreated Parietene, and the control group. Gore-Tex Dual Mesh resulted in less adhesions, adhesion area, mean strength of separation, and work of separation than the untreated Parietene group and the control group. Sepramesh resulted in less strength and work of separation compared to the control group. Conclusions: The incidence of adhesions and work and strength of adhesion separation are reduced when using a treated mesh, compared to the untreated mesh and the control group without mesh. Parietex Composite, Parietene Composite, Bard Composix E/X, and Gore-Tex Dual Mesh were superior to Sepramesh, untreated Parietene, and the control group in the prevention of adhesion formation.Disclosure statement: This study was sponsored by: Sofradim, Trévoux, France     

腹腔镜腹壁疝修补术联合围手术期康复训练对成人腹壁疝患者术后胃肠功能恢复及复发的影响

目的探讨腹腔镜腹壁疝修补术联合围手术期康复训练对成人腹壁疝患者术后胃肠功能恢复及复发的影响。 方法分析2016年2月至2018年12月在北京怀柔医院就诊的80例腹壁疝患者,根据患者所采取的手术方法分为对照组和观察组,各40例。2组均采用腹腔镜内补片植入术,观察组无康复介入,治疗组采用术前1周、术后3周的康复训练,训练内容包括腹式呼吸训练、腹内外斜肌、腹横肌、多裂肌、盆底肌等核心肌群激活训练。记录手术相关指标及胃肠功能恢复指标;检测并比较2组治疗前后血清白细胞介素-6（IL-6）、C-反应蛋白（CRP）水平;统计术中及术后并发症;随访1年,观察疝复发率。 结果相较于对照组,观察组术后疼痛时间和下床活动时间均缩短（P<0.05）,手术时间和术中出血量无明显差异（P>0.05）;观察组术后首次肠鸣音时间、肛门排气时间和首次排便时间均显著低于对照组（P<0.05）;术后2组IL-6和CRP水平均高于术前（P<0.05）,但观察组IL-6和CRP水平低于对照组（P<0.05）;观察组尿潴留发生率低于对照组（P<0.05）,2组患者的术中出血、肠管损伤、血清肿、慢性疼痛、复发率差异无统计学意义（P>0.05）。 结论腹腔镜腹壁疝修补术联合围手术期康复训练可促进成人腹壁疝患者术后胃肠功能恢复,降低机体炎性反应,且安全性高,降低术后复发率,具有较好的临床推广应用价值。     

应用补片修补巨大腹壁切口疝23例报告

目的 总结应用补片无张力修补巨大腹壁切口疝经验.方法 回顾性分析2000年6月至2009年8月间收治的23例巨大腹壁切口疝病人的临床资料.结果 23例均用补片进行修补,其中14例采用聚丙烯Marlex网片,9例采用Composix复合补片,术后无严重并发症发生,随访5～48个月无复发.结论 掌握正确的修补方法 正确选择...     

回肠膀胱腹壁造瘘术与Bricker术的疗效对比

目的分别对全膀胱切除术后行回肠膀胱腹壁造瘘术、Bricker术的膀胱尿路上皮癌患者进行长期随访,评价两种尿流改道术式的临床疗效。方法 2010年1月至2019年4月,我科共行98例全膀胱切除术,其中57例行回肠膀胱腹壁造瘘术(造瘘术组),41例行Bricker术(Bricker术组),比较两种不同术式患者的一般资料、围手术期情况、术后并发症等。结果两组一般临床资料比较,差异无显著统计学意义(P>0.05);造瘘术组平均手术时间(4.4±0.3)h,显著低于Bricker术组(5.8±0.3)h(P<0.05),但两组在术中出血、术后住院时间、术后拔除盆腔引流管时间、术后拔除输尿管支架时间等方面无统计学差异(P>0.05);造瘘术组术后总肾功异常发生率(2.0%vs.11.2%)、造瘘口周围皮炎及疤痕发生率(0.0%vs.10.2%)均显著低于Bricker术组(P<0.05)。此外,两组患者在随访时间、术后TNM分期、漏尿、肠梗阻、肾积水、膀胱结石、回肠造瘘口坏死或狭窄等方面均无统计学差异(P>0.05)。结论与Bricker术相比,回肠膀胱腹壁造瘘术临床疗效可靠,手术疗效无明显差别,但手术时间更短,术后总肾功异常发生率更低、造瘘口并发症更少,可弥补Bricker术的不足,有望成为更加理想的尿流改道术式。