共查询到18条相似文献,搜索用时 361 毫秒
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目前,癌症是导致人类死亡的主要因素之一。尽管在癌症治疗方面取得了巨大进展,但是,其较高的复发率还是会导致死亡。连续治疗失败的一个可能原因是,残留的恶性细胞有类似干细胞的分化潜能,这样就能再次形成肿瘤和造成病灶转移。肿瘤干细胞(cancer stem cell,CSC)假说认为,肿瘤组织中存在具有自我跟新能力,无限增殖和肿瘤形成能力的一小部分肿瘤细胞,近年来,随着在血液肿瘤和实体瘤中相继发现CSC存在的相关证据,对CSC的生物学特性的认识不断深入,对肿瘤的复发、病灶转移、耐药性形成也有了新的观点和研究方向,目前的研究主要集中在其分离鉴定阶段,本文就近年来该方面的研究进展作一综述。 相似文献
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肿瘤干细胞(cancer stem cell,CSC)是一小群能够自我复制和分化的细胞,它既具有干细胞的特征,又有自身独有的特点。结肠癌中肿瘤干细胞的发现为治愈结肠癌提供了新的治疗策略。目前关于结肠癌中肿瘤干细胞的分选标记和分子细胞学特性研究较多,但仍然存在较多争议。 相似文献
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肿瘤干细胞及其耐药机制 总被引:3,自引:0,他引:3
肿瘤干细胞是存在于造血系统肿瘤和一些实体瘤中具有干细胞特性的细胞。肿瘤干细胞假说认为,经药物治疗后肿瘤复发和转移与肿瘤干细胞残存有密切关系。其原因可能是肿瘤干细胞高表达ABC转运蛋白和Bcl-2抗凋亡蛋白,同时其本身又具有一些干细胞特性。对肿瘤干细胞耐药机制的研究,将有助于发现新的肿瘤治疗靶点和更好的抗癌策略。 相似文献
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肿瘤干细胞 (CSC)是一类具有肿瘤起始、自我更新及无限增殖潜能的细胞亚群,与肿瘤的局部复发与远处转移密切相关,是肿瘤放射治疗抵抗的根源。非小细胞肺癌是目前发病率及致死率较高的恶性肿瘤,已证实非小细胞肺癌中具有干细胞特性的CSC亚群,目前通过分离CD133等一系列已知免疫表型阳性细胞是获得非小细胞肺癌CSC的主要手段。研究证实CSC主要是通过DNA损伤、细胞自噬和缺氧肿瘤微环境等机制介导非小细胞肺癌的放疗抵抗效应。本文主要对非小细胞肺癌CSC的生物学特性、免疫表型表达及放疗抵抗的分子机制进行综述,以期为提高非小细胞肺癌放射疗效提供线索和依据。 相似文献
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Cancer stem cells (CSCs) possess self-renewal and differentiation potential, which may be related to recurrence, metastasis, and radiochemotherapy resistance during tumor treatment. Understanding the mechanisms via which CSCs maintain self-renewal may reveal new therapeutic targets for attenuating CSC resistance and extending patient life-span. Recent studies have shown that amino acid metabolism plays an important role in maintaining the self-renewal of CSCs and is involved in regulating their tumorigenicity characteristics. This review summarizes the relationship between CSCs and amino acid metabolism, and discusses the possible mechanisms by which amino acid metabolism regulates CSC characteristics particularly self-renewal, survival and stemness. The ultimate goal is to identify new targets and research directions for elimination of CSCs. 相似文献
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Elsa N Garza-Trevi?o Salvador L Said-Fernández Herminia G Martínez-Rodríguez 《Cancer cell international》2015,15(1)
An area of research that has been recently gaining attention is the relationship between cancer stem cell (CSC) biology and chemo-resistance in colon cancer patients. It is well recognized that tumor initiation, growth, invasion and metastasis are promoted by CSCs. An important reason for the widespread interest in the CSC model is that it can comprehensibly explain essential and poorly understood clinical events, such as therapy resistance, minimal residual disease, and tumor recurrence. This review discusses the recent advances in colon cancer stem cell research, the genes responsible for CSC chemoresistance, and new therapies against CSCs. 相似文献
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Zhao Y Bao Q Renner A Camaj P Eichhorn M Ischenko I Angele M Kleespies A Jauch KW Bruns C 《The International journal of developmental biology》2011,55(4-5):477-482
Cancer stem cells (CSCs) or tumor initiating cells were identified and characterized as a unique subpopulation with stem cell features in many types of cancer. Current CSC studies provide novel insights regarding tumor initiation, progression, angiogenesis, resistance to therapy and interplay with the tumor micro-environment. A cancer stem cell niche has been proposed based on these findings. The niche provides the soil for CSC self-renewal and maintenance, stimulating essential signaling pathways in CSCs and leading to secretion of factors that promote angiogenesis and long term growth of CSCs. We present evidence which has emerged over the past 5 years indicating interaction of CSCs with angiogenesis in the proposed "vascular niche". Based on these findings, targeting the "cancer stem cell niche" by combining an individualized anti-CSC approach with treatment of their microenvironment may represent a novel therapeutic strategy against solid tumor systems. 相似文献
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Tobias Schatton Natasha Y. Frank Markus H. Frank 《BioEssays : news and reviews in molecular, cellular and developmental biology》2009,31(10):1038-1049
Cancer stem cells (CSC) represent malignant cell subsets in hierarchically organized tumors, which are selectively capable of tumor initiation and self‐renewal and give rise to bulk populations of non‐tumorigenic cancer cell progeny through differentiation. Robust evidence for the existence of prospectively identifiable CSC among cancer bulk populations has been generated using marker‐specific genetic lineage tracking of molecularly defined cancer subpopulations in competitive tumor development models. Moreover, novel mechanisms and relationships have been discovered that link CSC to cancer therapeutic resistance and clinical tumor progression. Importantly, proof‐of‐principle for the potential therapeutic utility of the CSC concept has recently been provided by demonstrating that selective killing of CSC through a prospective molecular marker can inhibit tumor growth. Herein, we review these novel and translationally relevant research developments and discuss potential strategies for CSC‐targeted therapy in the context of resistance mechanisms and molecular pathways preferentially operative in CSC. 相似文献
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癌症是严重威胁人类生命健康的疾病之一,传统治疗方法未能彻底根除癌症。究其原因是癌症的发病机制复杂,至今尚未完全认识。肿瘤干细胞理论的提出为肿瘤的发生、发展乃至术后复发提供了新的研究思路,同时也为癌症的治疗带来了新的曙光。但由于肿瘤干细胞含量极低、分离困难,给肿瘤干细胞的研究带来诸多不便。目前常用的分离方法为无血清培养法与流式分选法,但二者均存在一定的缺陷,因此亟须建立一种新型有效地分离方法。肿瘤干细胞与普通干细胞有许多相似的信号通路,因此可利用干细胞的微环境筛选分离分化程度较低的肿瘤干细胞。水凝胶由于其独特的性质,目前广泛用于细胞的三维培养。有鉴于此,科研工作者利用水凝胶模拟普通干细胞生长的力学环境筛选、富集肿瘤干细胞。本文就肿瘤干细胞目前常用分离及鉴定方法,同时结合国内外最新的肿瘤干细胞分离方法进行综述。 相似文献
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《生物化学与生物物理学报:疾病的分子基础》2020,1866(4):165424
Recent advances in research on cancer have led to understand the pathogenesis of cancer and development of new anticancer drugs. Despite of these advancements, many tumors have been found to recur, undergo metastasis and develop resistance to therapy. Accumulated evidences suggest that small population of cancer cells known as cancer stem cells (CSC) are responsible for reconstitution and propagation of the disease. CSCs possess the ability to self-renew, differentiate and proliferate like normal stem cells. CSCs also appear to have resistance to anti-cancer therapies and subsequent relapse. The underlying stemness properties of the CSCs are reliant on multiple molecular targets such as signaling pathways, cell surface molecules, tumor microenvironment, apoptotic pathways, microRNA, stem cell differentiation, and drug resistance markers. Thus an effective therapeutic strategy relies on targeting CSCs to overcome the possible tumor relapse and chemoresistance. The targeted inhibition of these stem cell biomarkers is one of the promising approaches to eliminate cancer stemness. This review article summarizes possible targets of cancer cell stemness for the complete treatment of cancer. 相似文献
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肿瘤微环境是一个复杂的组织样结构,具有丰富的表型和功能异质性。不同浓度的趋化因子、细胞因子与组成肿瘤微环境的细胞间相互作用,可激活上皮–间质转化(epithelial-mesenchymal transition,EMT)相关的信号通路及控制肿瘤干细胞(cancer stem cells,CSCs)的生成。EMT的异常激活会促进肿瘤细胞的可塑性,赋予上皮细胞间充质特性,并与癌细胞获得侵袭性的特征密切相关。CSCs是一类具有高致瘤潜能的细胞群,其能很容易地适应周围环境的变化,与肿瘤内其他细胞相比具有较强的抗药性。该文对肿瘤微环境中EMT与CSC的作用机制及相关信号通路的研究进展进行综述。 相似文献
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Cancer stem cells(CSC) are thought to be malignant cells that have the capacity to initiate and maintain tumor growth and survival. Studies have described CSC in various gastrointestinal neoplasms such as colon, pancreas and liver and gastroesophageal tumors. The mechanism by which CSC develop remains unclear. Several studies have explored the role of dysregulation of the Wnt/β-catenin, transformation growth factor-beta and hedhog pathways in generation of CSC. In this review, we discuss the various molecular abnormalities that may be related to formation of CSC in gastrointestinal malignancies, strategies to identify CSC and therapeutic strategies that are based on these concepts. Identification and targeting CSC is an intriguing area and may provide a new therapeutic option for patients with cancer including gastrointestinal malignancies. Although great progress has been made, many issues need to be addressed. Precise targeting of CSC will require precise isolation and characterization of those cells. This field is also evolving but further research is needed to identify markers that are specific for CSC.Although the application of this field has not entered the clinic yet, there continues to be significant optimism about its potential utility in overcoming cancer resistance and curing patients with cancer. 相似文献