| 人脑胶质母细胞瘤miR-4516表达与病人预后的关系 |
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| 引用本文： | 兰展仇洪冯磊黄章峰禤义张传东盘丽华.人脑胶质母细胞瘤miR-4516表达与病人预后的关系[J].中国临床神经外科杂志,2022,27(2):107-109. |
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| 作者姓名： | 兰展仇洪冯磊黄章峰禤义张传东盘丽华 |
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| 作者单位： | 547000广西河池，右江民族医学院附属河池医院（河池市人民医院）神经外科（兰展、仇洪、冯磊、黄章峰、禤义、张传东、盘丽华） |
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| 摘 要： | 目的 探讨人胶质母细胞瘤（GBM）组织微小核糖核酸-4516（miR-4516）的表达情况及其与病人预后的关系。方法选取 2015年 1月~2019年 5月手术切除的 GBM组织 89例和颅脑损伤内减压术切除的非肿瘤脑组织 35例为对照组，采用 qRT-PCR检测 miR-4516的表达水平，根据 miR-4516表达水平的中位数分为高表达和低表达。GBM病人术后随访 2年，记录生存情况。结果 GBM组织 miR-4516表达水平（ 5.32±1.75）]明显高于对照组（ 1.13±0.45）；P<0.01]。术后 2年随访，42例（47.19%）生存，47例 47（52.81%）死亡。多因素 Cox回归分析显示，miR-4516高表达是 GBM生存预后病例的独立危险因素（P<0.05）。生存曲线分析显示 miR-4516高表达组 2年累积生存率（27.45%）明显低于低表达组（73.68%；P<0.001）。结论 GBM组织 miR-4516表达增高，其高表达是病人预后不良的危险因素。
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| 关 键 词： | 胶质母细胞瘤 微小核糖核酸 miR-4516 预后 |
Relationship between expression of miR-4516 in human glioblastoma tissues and patients’ prognoses |
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| LAN Zhan,QIU Hong,FENG Lei,HUANG Zhang-feng,FU Yi,ZHANG Chuan-dong,PAN Li-hua..Relationship between expression of miR-4516 in human glioblastoma tissues and patients’ prognoses[J].Chinese Journal of Clinical Neurosurgery,2022,27(2):107-109. |
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| Authors: | LAN Zhan QIU Hong FENG Lei HUANG Zhang-feng FU Yi ZHANG Chuan-dong PAN Li-hua |
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| Affiliation: | Department of Neurosurgery, Hechi Hospital Affiliated to Youjiang Medical College for Nationalities (Hechi People’s Hospital), Hechi 547000, China |
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| Abstract: | Objective To investigate the expression level of microRNA-4516 (miR-4516) in human glioblastoma (GBM) tissuesand its relationship with the patients prognoses. Methods The expression levels of miR-4516 were detected in GBM tissues obtainedfrom 89 GBM patients who underwent microsurgery and in non-tumor cerebral tissues obtained from 35 patients with traumatic braininjury (control group) who underwent decompression from January 2015 to may 2019, using qRT-PCR. The GBM patients were divideinto high-expression and low-expression groups according the medium expression level of miR-4516. The GBM patients were followedup for 2 years and the survval status was recorded. Results The expression level of miR-4516 in GBM tissues was significantly higherthan that in the control group (P<0.05). Of 89 GBM patients, 42 patients (47.19%) survived and 47 (52.81%) died at the end of thefollow-up. Multivariate Cox regression analysis showed that high expression of miR-4516 was an independent risk factor for the poorsurvival of GBM patients (P<0.05). Survival curve analysis showed that the 2-year cumulative survival rate (27.45%) of the miR-4516high expression group was significantly lower than that (73.68%) of the low expression group (P<0.001). Conclusions The expression of miR-4516 in GBM tissues is increased, and its high expression is a risk factor for poor prognosis of GBM patients. |
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| Keywords: | Glioblastoma MicroRNA MiR-4516 Prognosis |
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