| 癌干细胞与肿瘤的放射抗性 |
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| 引用本文： | 谭伟,让蔚清,周平坤.癌干细胞与肿瘤的放射抗性[J].国际放射医学核医学杂志,2013,37(3):177-180. |
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| 作者姓名： | 谭伟 让蔚清 周平坤 |
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| 作者单位： | 1.421001 湖南衡阳，南华大学公共卫生学院环境医学与放射卫生研究所 |
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| 基金项目： | 国家自然科学杰出青年基金(项目编号：30825011) |
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| 摘 要： | 有关癌干细胞及其生物学特性研究信息的不断积累，推动了放射肿瘤生物学的发展。近年来的研究发现，癌干细胞和静止期癌细胞可能是导致肿瘤放射抗性增加和肿瘤放射治疗后复发的主要细胞学基础，有关这两种癌细胞亚群的放射敏感性及其机制的研究进展迅速，为提高肿瘤对放射治疗敏感性的措施研究提供了新的学术思路。该文将就癌细胞亚群的放射分子生物学特性，分析讨论肿瘤放射抗性的细胞学基础和相关分子机制。
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| 关 键 词： | 肿瘤 肿瘤干细胞 放射抗性 DNA修复 |
| 收稿时间： | 2013-04-08 |
Cancer stem cell and its relevance to tumors resistance to radiotherapy |
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| Wei TAN,Wei-qing RANG,Ping-kun ZHOU.Cancer stem cell and its relevance to tumors resistance to radiotherapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(3):177-180. |
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| Authors: | Wei TAN Wei-qing RANG Ping-kun ZHOU |
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| Affiliation: | 1.Institute of Environmental Medicine and Radiation Hygiene, College of Public Health, University of South China, Hengyang 421000, China |
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| Abstract: | The gradually accumulated information and knowledge regarding cancer stem cell or stem-like cancer cell greatly potentiated the research progression of radiation oncology and biology. In recent years, a series studies have uncovered that the cancer stem cell and cancer quiescent cell could be the major cells origin attributed to the radioresistance and recurrence of tumors in the course of radiotherapy. A rapid research progression has already been achieved respecting the radiosensitivity and related mechanisms of these two subsets of cancer cells, and which provides an idea strategy for development of the measures targeting tumor radioresistance. This paper reviewed and discussed the cellular basis and molecular mechanism of the tumor radioresistance from the aspects of cancer cells subsets and the radiobiological characteristics. |
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