| 低剂量X射线全身照射诱导小鼠胸腺细胞CD_3分子表达的适应性反应 |
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| 引用本文： | 鞠桂芝,苏旭,齐进,张迎春,刘树铮.低剂量X射线全身照射诱导小鼠胸腺细胞CD_3分子表达的适应性反应[J].中华放射医学与防护杂志,1996(5). |
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| 作者姓名： | 鞠桂芝 苏旭 齐进 张迎春 刘树铮 |
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| 作者单位： | 白求恩医科大学卫生部放射生物重点实验室 |
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| 摘 要： | 采用免疫荧光流式细胞术（ＦＣＭ）观察了昆明种小鼠胸腺细胞ＣＤ３分子表达的变化。首次报道了０．０７５ＧｙＸ射线单次全身照射可诱导小鼠胸腺细胞ＣＤ３分子表达对其后１．５Ｇｙ攻击剂量照射的适应性反应。证实，１．５Ｇｙ全身照射后胸腺ＣＤ３阳性细胞明显减少，照后１８小时仅为假照射组的３３．７４％。当１．５Ｇｙ照射前６小时预先照射０．０７５Ｇｙ时，可明显减轻其后攻击剂量对ＣＤ３分子表达的抑制作用，此时，ＣＤ３阳性细胞数显著高于单纯攻击剂量对照组（Ｐ＜０．０１）。对其机理进行了讨论。
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| 关 键 词： | 低剂量辐射，适应性反应，CD_3分子表达，胸腺细胞 |
Adaptive response of CD_3 expression of thymocytes in mice induced by low dose X-ray irradiation |
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| Ju Guizhi,Su Xu, Qi Jin,er al..Adaptive response of CD_3 expression of thymocytes in mice induced by low dose X-ray irradiation[J].Chinese Journal of Radiological Medicine and Protection,1996(5). |
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| Authors: | Ju Guizhi Su Xu Qi Jin er al |
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| Abstract: | Flow cytometry was used to analyze CD_3 expression of thymocytes in mice for their immunofluorescence stained with monoclonal antibody. It was found that the adaptive response of CD_3 expression of thymocytes could be induced by 0 . 075Gy (conditioning dose, D_1) whole body X-irradiation which was delivered 6h before 1. 5Gy (challenge dose,D_2) exposure. The results showed that the number of CD cells of thymus was significantly higher in D_1 D_2 guoup than that in D_2 group (P< 0. 01) . |
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| Keywords: | Low dose radiation Adaptive response CD_3 expression Thymocytes |
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