| 双特异性抗体研究进展 |
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| 引用本文： | 潘庆瑾,陈哲文.双特异性抗体研究进展[J].国际生物制品学杂志,2022,45(6):354-360. |
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| 作者姓名： | 潘庆瑾 陈哲文 |
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| 作者单位： | 1上海生物制品研究所有限责任公司第一研究室，上海 200051；2上海生物制品研究所有限责任公司，上海 200051 |
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| 摘 要： | 抗体药物具有特异性高、不良反应少的特点，已成为肿瘤治疗的热点。双特异性抗体（双抗）是指同时结合2个不同抗原或同一抗原2个表位的抗体。与单特异性抗体相比，双抗具有高度特异性，增强了治疗有效性和安全性，同时减少了不良反应。已有多种双抗药物获批上市，进入临床研究的双抗药物数量不断增加。双抗药物的形式持续在更新，应用范围也在扩大，在未来具有非常好的应用前景。此文就目前已有的双抗类型、作用机制及目前双抗制备上面临的困难等进行概述。
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| 关 键 词： | 双特异性抗体 抗肿瘤药 肿瘤 单链抗体 |
Research progress of bispecific antibodies |
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| Abstract: | Antibody drug attracts much attention in tumor treatment for its high specificity and low side effects. Bispecific antibody (BsAb) simultaneously bind two different antigens or two epitopes of one antigen. Compared with monospecific antibody, BsAb shows higher specificity as well as better therapeutic effect and safety, and reduces side effects. Several BsAb drugs have been approved to the market and increasing numbers of drugs enter clinical studies. BsAb formats are constantly updating, and application range of BsAbs is increasing, which shows a good application prospect in the future. In this paper, the types, mechanisms, and difficulties of BsAb preparation are summarized. |
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| Keywords: | Bispecific antibodies Antineoplastics Neoplasms Single chain antibody |
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