| HBV-M在慢乙肝、肝硬化及肝癌中的表达及意义 |
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| 引用本文： | 单静,唐宽银,田方圆,曹武奎.HBV-M在慢乙肝、肝硬化及肝癌中的表达及意义[J].现代临床医学,2014,40(2):100-102. |
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| 作者姓名： | 单静 唐宽银 田方圆 曹武奎 |
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| 作者单位： | 天津医科大学研究生院,天津医科大学研究生院,天津医科大学研究生院,天津市第二人民医院 天津市肝病医学研究所 |
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| 基金项目： | 国家“十二五”科技重大专项(No.2012ZX10005006) |
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| 摘 要： | 目的 比较HBsAg、HBeAg滴度与HBV DNA水平在慢性乙型肝炎、乙型肝炎肝硬化及HBsAg 阳性的原发性肝癌患者中的变化,并探讨其对病情进展的影响。方法 在149例慢性乙型肝炎患者,115例乙型肝炎肝硬化患者及146 例肝癌患者中,采用荧光PCR定量法和Abbott化学发光微粒子免疫分析技术分别测定HBV DNA定量水平及HBsAg和HBeAg的滴度, 分析它们在这三组患者中的变化。结果1.HBeAg定量值在三组患者中比较有统计学意义(F=9.944,P=0.007)；乙型肝炎组与肝硬化组、肝癌组比较均有统计学意义(x2=4.147,P=0.042; x2=9.499,P=0.002)；肝硬化组与肝癌组比较无统计学意义(x2=0.747,P=0.387)。2.在不同HBeAg状态下,HBsAg定量值在乙型肝炎组与肝硬化组患者中比较均有统计学意义(t=2.549,P=0.012;t=2.428,P=0.017)；HBsAg定量值在肝癌组中无统计学意义(t=1.375,P=0.171)；HBVDNA定量值在三组患者中比较,差异均有统计学意义(Z分别为3.148、6.544、4.520,P<0.05)。 结论 定量检测慢性乙型肝炎、肝硬化及肝癌患者血清中的HBsAg、HBeAg及HBV DNA的变化有一定的临床意义,将三者结合能更好地为临床提供准确可靠的诊断和治疗数据。
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| 关 键 词： | 肝炎 乙型 慢性 肝硬化 肝细胞癌 HBsAg HBeAg HBV DNA |
| 收稿时间： | 2013/11/8 0:00:00 |
| 修稿时间： | 2013/11/8 0:00:00 |
Significance of HBV-M Expression in Chronic Hepatitis B,Liver Cirrhosis and Hepatocellular Carcinoma |
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| SHAN Jing,TANG Kuanyin,TIAN Fangyuan and CHAO Wukui.Significance of HBV-M Expression in Chronic Hepatitis B,Liver Cirrhosis and Hepatocellular Carcinoma[J].Journal of Modern Clinical Medicine,2014,40(2):100-102. |
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| Authors: | SHAN Jing TANG Kuanyin TIAN Fangyuan and CHAO Wukui |
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| Abstract: | objective To investigate the discrepancy of HBV DNA level ,HBsAg and HBeAg titer among paitents in chronic hepatitis B, HBV-related liver cirrhosis and hepatocellular carcinoma and to discuss the impact on disease progression.Methods HBV DNA level , HBsAg and HBeAg titer were measured among 149 patients of CHB,115 patiens of LC and 146 patients of HCC cases using fluorescence quantitative PCR and Abbott chemiluminescent microparticle immunoassay technology ,respectively, and analysis of the changes of which in the three groups of patients. Results 1. HBeAg titer level in the three groups of patients were statistically significant (F=9.944,P=0.007); The differences among CHB group, LC group and HCC group were statistically significant (x2=4.147,P=0.042;x2= 9.499,P=0.002);There was no statistically significant difference in HBeAg titre between LC and HCC group (x2=0.747,P=0.387);2. In different conditions of HBeAg, HBsAg titer level in patients with CHB and LC group have statistical significance(t=2.549,P=0.012;t=2.428,P=0.017);There was no statistically significant difference in HCC group(t=1.375,P=0.171);HBV DNA quantitative values in three groups of patients were statistically significant (Z were 3.148,6.544,4.520,P< 0.05).Conclusion A certain clinical significance was taken place when quantitatively detected the changes of serum in HBsAg,HBeAg and HBVDNA through the 3 groups of patients of CHB,LC and HCC, Combination of the three can provide accurate and reliable data for clinical diagnosis and treatment. |
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| Keywords: | hepatitis B chronic liver cirrhosis hepatocellular carcinoma HBsAg HBeAg HBV DNA |
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