| 天然药物对脑缺血再灌注损伤保护作用的研究进展 |
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| 作者姓名： | 张浩楠 杨辉 |
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| 作者单位： | 1.河北北方学院药学系2016 级临床药学，张家口，075000，中国
2 河北北方学院药学系，张家口，075000，中国 |
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| 摘 要： | 脑血管疾病是临床上的一种常见病和多发病，死亡率和致残率极高，严重威胁着人类的健康和生命，给社会和家庭带来的负担不可估量。因此需要科学家和临床医生付出巨大的努力来寻求潜在的致病机制，从而采取适当的预防措施和成功的治疗方法。脑缺血再灌注损伤（cerebral ischemia-reperfusion injury，CIRI）涉及多种机制，主要包括自由基作用、兴奋性氨基酸、细胞Ca2+ 超载等。了解CIRI 的机制，加深对脑缺血损伤过程的认识，有利于用药的研究与选择，从而达到治疗的目的。天然药物用于治疗脑缺血的历史悠久，也积累了丰富的理论知识。从天然药物中筛选有效成分也是目前研发的趋势。全世界都在促进天然药物化学成分的分离及其在脑疾病治疗中的应用。我国研究者对此进行了一系列的研究，目前已经取得了很大的进展。该文对脑缺血损伤机制及各类天然药物活性成分对脑缺血再灌注损伤的研究进展做一简单综述。
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| 关 键 词： | 脑缺血再灌注损伤 天然药物 研究进展 |
Recent Advances in the Research of the Protective Effect ofNatural Drugs on Cerebral Ischemia-Reperfusion Injury |
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| Authors: | ZHANG Hao-nan YANG Hui |
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| Affiliation: | 1 Grade 16，Department of Pharmacy，Hebei North University，Zhangjiakou，75000，China
2 Department of Pharmacy，Hebei North University，Zhangjiakou，075000，China
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| Abstract: | Cerebrovascular disease is a common and frequently-occurring disease in the clinic. The mortality and disability rate are extremely high. It seriously threatens human health and life，and the burden on society and families is immeasurable. Therefore，scientists and clinicians need to make great efforts to find potential pathogenic mechanisms，so as to take appropriate preventive measures and successful treatment methods. Cerebral ischemia-reperfusion injury （CIRI） involves a variety of mechanisms，including free radical action，excitatory amino acids，cellular Ca2+ overload. To understand the mechanism of CIRI and deepen the understanding of the process of cerebral ischemic injury is conducive to the research and selection of medication，so as to achieve the purpose of treatment. Natural medicines have a long history of treatment for cerebral ischemia and have accumulated rich theoretical knowledge. Screening active ingredients from natural medicines is also the current trend of research and development. The whole world is promoting the separation of chemical components of natural medicines and their application in the treatment of brain diseases. Researchers in my country have carried out aseries of studies on this，and have made great progress. This article briefly reviews the researchprogress of cerebral ischemic injury mechanism and the active ingredients of various naturalmedicines on cerebral ischemia-reperfusion injury. |
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| Keywords: | cerebral ischemia-reperfusion injury natural medicine research progress
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