蛋白质S- 亚硝基化的调控机制及其与神经系统疾病的关系 |
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作者姓名: | 华丹 周雪霞 王虔 石翠娟 汤立达 于士柱 |
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作者单位: | 1 天津医科大学总医院,天津,300052,中国
2 天津药物研究院,天津,300193,中国 |
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基金项目: | 国家自然科学基金项目(No.81402050,No.81502166,No.81672592,No.81872061,No.81972354);天津市自然科学基金项目(No.16JCQNJC13400,No.17JCYBJC27100,No.19JCZDJC64900);中国留学基金委项目(No.201606945004);中央高校基本科
研业务费专项资金资助项目(No.3332021084) |
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摘 要: | 蛋白质S- 亚硝基化是指将一氧化氮(nitric oxide,NO)衍生基团连接到半胱氨酸(cysteine,Cys)硫醇上生成S- 亚硝基硫醇(S-nitrosothiol,SNO)的过程,其作为可逆的翻译后修饰有助于信号传导,在神经系统中参与多种生理和病理过程。该文将从S- 亚硝基化的调节机制及其与神经系统性疾病发病过程和治疗的关系进行概述,以期为未来该类研究的发展提供一个新思路。
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关 键 词: | S- 亚硝基化 一氧化氮 神经系统疾病 |
The Regulatory Mechanism of Protein S-Nitrosylation and Its Relationship with Nervous System Diseases |
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Authors: | HUA Dan ZHOU Xue-xia WANG Qian SHI Cui-juan TANG Li-da YU Shi-zhu |
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Affiliation: | 1 Tianjin Medical University General Hospital,Tianjin,300052,China
2 Tianjin Institute of Pharmaceutical Research,Tianjin,300193,China |
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Abstract: | Protein S-nitrosylation refers to the process of attaching a nitric oxide (NO)-derived group to a cysteine (Cys) thiol to generate S-nitrosothiol (SNO). S-nitrosylation is a reversible posttranslational modification,which acts a key role in the signal transduction pathway contributing to a variety of physiological and pathological processes in the nervous system. This article will summarize the regulatory mechanism of S-nitrosylation,its relationship with the pathogenesis,and the treatment of neurological diseases based on S-nitrosylation,in order to
provide a new idea for the development of such research in the future. |
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Keywords: | S-nitrosylation nitric oxide(NO) neurological diseases |
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