| 血清iPTH、血浆BNP、NT-proBNP水平在CKD 5期患者心功能评价中的应用价值分析 |
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| 引用本文： | 刘俊生,刘莉,杨丽娟,吴雪平.血清iPTH、血浆BNP、NT-proBNP水平在CKD 5期患者心功能评价中的应用价值分析[J].中华全科医学,2018,16(9):1427-1430. |
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| 作者姓名： | 刘俊生 刘莉 杨丽娟 吴雪平 |
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| 作者单位： | 1. 合肥市第二人民医院肾内科, 安徽 合肥 230011; |
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| 基金项目： | 2016年度安徽高校自然科学研究项目(KJ2016A481) |
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| 摘 要： | 目的 探讨血清iPTH、血浆BNP、NT-proBNP水平在慢性肾脏病(chronic kidney disease,CKD)5期患者心功能评价中的价值。 方法 选取80例CKD 5期并伴有不同程度心功能衰竭的患者,完善血清iPTH、血浆BNP、NT-proBNP水平检查和心脏彩超检查。其中NYHA心功能分级Ⅰ级(甲组)23例,Ⅱ级(乙组)40例,Ⅲ-Ⅳ级(丙组)17例,并选取同期入我院体检的健康志愿者30例作为对照组。比较3组患者血清iPTH、血浆BNP、NT-proBNP水平检查和心脏彩超检查结果的差异,并分析其与心功能指标的相关性。 结果 甲、乙、丙组患者血清iPTH、血浆BNP、NT-proBNP水平均明显高于对照组(P<0.01)。甲、乙、丙组患者LVEDd、LVEDs、IVST、LVMI水平均明显高于对照组,LVEF、FS水平均明显低于对照组(P<0.05)。血清iPTH、血浆BNP、NT-proBNP水平与心功能指标均为强相关,且LVEDd、LVEDs、IVST、LVMI与血清iPTH、血浆BNP、NT-proBNP水平呈正相关,LVEF、FS与血清iPTH、血浆BNP、NT-proBNP水平呈负相关(P<0.05)。 结论 血清iPTH、血浆BNP、NT-proBNP水平与CKD 5期患者心功能指标相关性较强,在患者心功能评价中具有较高的应用价值。
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| 关 键 词： | 慢性肾脏病 心功能 iPTH BNP NT-proBNP |
| 收稿时间： | 2017-12-10 |
Serum iPTH,plasma BNP and NT-proBNP levels for the evaluation of cardiac function in patients with stage 5 chronic kidney disease |
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| Affiliation: | Department of Nephrology, the Second People's of Hefei, Hefei, Anhui 230011, China |
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| Abstract: | Objective To evaluate the value of serum iPTH, plasma BNP and NT-proBNP in the evaluation of cardiac function in patients stage 5 with chronic kidney disease (CKD). Methods Eighty stage 5 CKD patients with varying degrees of heart failure were selected to compare the serum iPTH, plasma BNP, NT-proBNP levels and echocardiography. Among them, there were 23 NYHA functional class Ⅰ (Group A), 40 class Ⅱ (Group B), and 17 class Ⅲ-Ⅳ (Group C). 30 healthy volunteers were selected as controls. The differences in serum iPTH, plasma BNP, and NT-proBNP levels and echocardiography among the three groups were compared, and their correlation with cardiac function was analyzed. Results Serum levels of iPTH, plasma BNP and NT-proBNP were significantly higher in patients in group A, B, and C than those in the control (P<0.01). The levels of LVEDd, LVEDs, IVST, and LVMI were significantly higher in group A, B, and C than those in the control group, and the levels of LVEF and FS were significantly lower than those in the control group (P<0.05). Serum iPTH, plasma BNP and NT-proBNP levels were all strongly correlated with cardiac function parameters, and LVEDd, LVEDs, IVST, LVMI were positively correlated with serum iPTH, plasma BNP and NT-proBNP levels. LVEF and FS were negatively correlated with serum iPTH, plasma BNP and NT-proBNP levels (P<0.05). Conclusion Serum iPTH, plasma BNP and NT-proBNP levels are closely associated with cardiac function in the patients with stage 5 CKD, with higher value in the assessment of cardiac function of patients. |
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