| Nesfatin-1在不同糖耐量病人血清中的水平差异分析 |
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| 引用本文： | 李婉婉,邓月珍,叶飞,朱亭.Nesfatin-1在不同糖耐量病人血清中的水平差异分析[J].蚌埠医学院学报,2021,46(6):783-785, 790. |
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| 作者姓名： | 李婉婉 邓月珍 叶飞 朱亭 |
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| 作者单位： | 蚌埠医学院附属泰兴市人民医院 内分泌科, 江苏 泰兴 225400 |
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| 基金项目： | 江苏省泰兴市人民医院院级课题try1910 |
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| 摘 要： | 目的分析Nesfatin-1在不同糖耐量病人血清中的差异，探讨Nesfatin-1与2型糖尿病(T2DM)发生发展的关系。方法选取糖尿病前期(PreDM)组包括空腹血糖受损(IFG)组及糖耐量异常(IGT)60例、T2DM组60例，另择同期体检健康者52名作为健康对照组，测定受试者体质量指数(BMI)、腰臀比(WHR)、空腹血糖(FPG)、空腹胰岛素(FIns)、糖化血红蛋白(HbA1c)、胰岛β细胞功能指数(HOMA-β)、Nesfatin-1。结果与健康对照组比较，PreDM组BMI、FPG、FIns、Nesfatin-1、HbA1c升高，HOMA-β下降，T2DM组BMI、FPG、FIns、HbA1c升高，HOMA-β、Nesfatin-1下降，差异均有统计学意义(P < 0.01)。与PreDM组比较，T2DM组BMI、FPG、HbA1c升高，HOMA-β、Nesfatin-1、FIns下降，差异均有统计学意义(P < 0.01)。Nesfatin-1与WHR、BMI、FIns、HOMA-β呈正相关，与FPG呈负相关(P < 0.05~P < 0.01)。多重线性回归分析显示，FPG值随着BMI、WHR、FIns值升高而增高，随着Nesfatin-1值升高而降低(P < 0.05~P < 0.01)。结论血清Nesfatin-1是影响糖代谢的因素之一。Nesfatin-1水平的下降很有可能参与了T2DM的发生发展。
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| 关 键 词： | 糖尿病 2型 糖尿病前期 Nesfatin-1 糖耐量 |
| 收稿时间： | 2020-07-20 |
Variation analysis of the serum levels of Nesfatin-1 in patients with different glucose tolerance |
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| LI Wan-wan,DENG Yue-zhen,YE Fei,ZHU Ting.Variation analysis of the serum levels of Nesfatin-1 in patients with different glucose tolerance[J].Journal of Bengbu Medical College,2021,46(6):783-785, 790. |
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| Authors: | LI Wan-wan DENG Yue-zhen YE Fei ZHU Ting |
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| Affiliation: | Department of Endocrinology and Metabolism, The Affiliated Taixing People's Hospital of Bengbu Medical College, Taixing Jiangsu 225400, China |
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| Abstract: | ObjectiveTo analyze the difference of the serum levels of Nesfatin-1 in patients with different glucose tolerance, and explore the relationship between Nesfatin-1 level and occurrence, development of type 2 diabetes mellitus(T2DM).MethodsSixty pateints with impaired fasting glucose(IFG) and impaired glucose tolerance(IGT), 60 patients with T2DM and 52 health examinees at the same time were divided into the prediabetes group(PreDM), T2DM group and healthy control group, respectively.The body mass index(BMI), waist hip ratio(WHR), fasting plasma glucose(FPG), fasting insulin(FIns), glycosylated hemoglobin(HbA1c), islet β-cell function index(HOMA-β) and Nesfatin-1 were detected in three groups.ResultsCompared with the healthy control group, the BMI, FPG, FIns, Nesfatin-1 and HbA1c increased significantly, the HOMA-β decreased significantly in PreDM group, and the differences of which were statistically significant between two groups(P < 0.01).Compared with the healthy control group, the BMI, FPG, FIns and HbA1c increased significantly, and the HOMA-β and the Nesfatin-1 decreased significantly in T2DM group, and the differences of which were statistically significant between two groups(P < 0.01).Compared with the PreDM group, the BMI, FPG and HbA1c increased significantly, the HOMA-β, Nesfatin-1 and FIns decreased significantly in T2DM group, and the differences of which were statistically significant between two groups(P < 0.01).The Nesfatin-1 was positively correlated with the WHR, BMI, FIns and HOMA-β, and negatively correlated with the FPG(P < 0.05 to P < 0.01).The results of multiple linear regression analysis showed that the FPG increased with the increasing of BMI, WHR and FIns, and decreased with the increasing of Nesfatin-1(P < 0.05 to P < 0.01).ConclusionsThe serum Nesfatin-1 is one of the factors affecting glucose metabolism.The decrease of Nesfatin-1 level is likely to be involved in the occurrence and development of T2DM. |
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