| 刺络放血治疗寻常型银屑病疗效及安全性Meta分析 |
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| 引用本文： | 仪 凡,,王晓旭,林诗佳,丁 薇,张广中.刺络放血治疗寻常型银屑病疗效及安全性Meta分析[J].陕西中医,2023,0(6):794-800. |
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| 作者姓名： | 仪 凡 王晓旭 林诗佳 丁 薇 张广中 |
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| 作者单位： | (1.北京中医药大学,北京 100020; 2.首都医科大学附属北京中医医院,北京 100010) |
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| 基金项目： | 国家自然科学基金资助项目(82274523)； |
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| 摘 要： | 目的:系统评价刺络放血治疗寻常型银屑病的效果与安全性。方法:检索建库以来应用刺络放血疗法治疗寻常型银屑病的随机对照试验(RCT),由2名研究者分别独立进行文献筛选和资料提取、并评价偏倚风险后，利用Rev Man 5.4软件合并分析。主要评价指标为：总有效率、银屑病面积与严重性指数(PASI评分)、红斑、鳞屑、浸润、瘙痒等皮损症状、银屑病患者生活质量(PQOLS评分)、复发率、不良反应发生率等。结果:共纳入12个RCT,共计997例患者。本系统评价结果显示联用刺络放血疗法较其他治疗方式在提高临床有效率RR=1.15,95%CI(1.09,1.21),P<0.00001]、降低PASI评分MD=-0.96,95%CI(-1.09,-0.82),P<0.00001]、改善红斑、鳞屑症状红斑：MD=-0.65,95%CI(-1.15,-0.15),P=0.01;鳞屑：MD=-0.47,95%CI(-0.74,-0.20),P=0.0007]、减少不良反应RR=0.49,95%CI(0.24,0.98),P=0.04]、减少复发RR=0.41,95%CI(0.22,0.76...
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| 关 键 词： | 寻常型银屑病 刺络放血 安全性 随机对照试验 系统评价 Meta分析 |
Systematic evaluation of the efficacy and safety of blood-letting puncture in the treatment of psoriasis vulgaris |
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| YI Fan,WANG Xiaoxu,LIN Shijia,DING Wei,ZHANG Guangzhong.Systematic evaluation of the efficacy and safety of blood-letting puncture in the treatment of psoriasis vulgaris[J].Shaanxi Journal of Traditional Chinese Medicine,2023,0(6):794-800. |
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| Authors: | YI Fan WANG Xiaoxu LIN Shijia DING Wei ZHANG Guangzhong |
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| Affiliation: | (Beijing University of Chinese Medicine,Beijing 100020,China) |
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| Abstract: | Objective:To systematically evaluate the efficacy and safety of pricking collaterals and bloodletting in the treatment of psoriasis vulgaris. Methods:Randomized controlled trials(RCTs)of pricking blood therapy in the treatment of psoriasis vulgaris since the establishment of the database were retrieved.Two researchers independently conducted literature screening and data extraction,and evaluated the risk of bias.Rev Man 5.4 software was used for combined analysis.The main evaluation indexes were:the total effective rate,psoriasis area and severity index(PASI score),erythema,scales,infiltration,itching and other skin lesions,quality of life in patients with psoriasis(PQOLS score),recurrence rate,incidence of adverse reactions,etc. Results:A total of 12 RCTs with a total of 997 patients were included.The results of this systematic review show that the combined use of pricking and bloodletting therapy compared with other treatments can improve the clinical effective rate RR=1.15,95%CI(1.09,1.21), P<0.00001] and reduce the PASI score MD=-0.96,95%CI(-1.09,-0.82),P<0.00001],improved erythema,scaling symptoms erythema:MD=-0.65,95%CI(-1.15,-0.15), P=0.01; scaling:MD=-0.47,95% CI(-0.74,-0.20),P=0.0007],reduction in adverse effects RR=0.49,95%CI(0.24,0.98), P=0.04],reduction in recurrence RR=0.41,95%CI(0.22,0.76),P=0.005],and improved quality of life MD=-1.78,95%CI(-2.48,-1.08),P<0.00001],the difference was significant and statistically significant.However,there were no statistics for infiltration MD=-0.33,95%CI(-0.91,0.25),P=0.26] and pruritus symptoms MD=-0.79,95%CI(-1.64,0.06),P=0.07] study meaning.Conclusion:Bloodletting therapy for pricking collaterals has high efficacy,good safety and low recurrence rate in the treatment of psoriasis vulgaris.However,the quality of the literature data included in this study is low.In the future,it is urgent to carry out large-sample and high-quality research to further scientifically verify the therapeutic advantages of bloodletting therapy. |
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| Keywords: | Blood-letting puncture Psoriasis vulgaris Safety Randomized controlled trial Systematic evaluation Meta analysis |
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