Effects of Curcumin on Serum Vitamin E Concentrations in Individuals with Metabolic Syndrome |
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| Authors: | Akram Mohammadi Hamid Reza Sadeghnia Maryam Saberi‐Karimian Hamideh Safarian Gordon A Ferns Majid Ghayour‐Mobarhan Amirhossein Sahebkar |
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| Affiliation: | 1. Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;2. Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;3. Student Research Committee, Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;4. Department of Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;5. Division of Medical Education, Brighton and Sussex Medical School, Brighton, Sussex, UK;6. Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;7. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran |
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| Abstract: | Vitamin E is an important lipid‐soluble antioxidant. The aim of the present study was to investigate the effect of curcumin on serum vitamin E levels in subjects with metabolic syndrome (MetS). A total of 120 subjects aged 18–65 years old with MetS were recruited in this study according to the International Diabetic Federation Criteria. Included subjects were randomized into three groups: subjects receiving lecithinized curcumin (1 g/day equivalent to 200‐mg pure curcumin per day) for a period of 6 weeks )n = 40), patients receiving unformulated curcumin (1 g/day) for a period of 6 weeks )n = 40) and a control group receiving placebo for the same period (n = 40). Vitamin E was determined in all patients before and after the intervention using high‐performance liquid chromatography method. Results showed that curcumin has no improving effect on serum levels of vitamin E (p > 0.05). There were significant differences between pre‐trial and post‐trial levels of vitamin E/low‐density lipoprotein cholesterol ratio (p < 0.05), vitamin E/high‐density lipoprotein cholesterol ratio (p < 0.05), vitamin E/total cholesterol ratio (p < 0.01) and vitamin E/triglyceride ratio (p < 0.05) between the three groups of the study. Results of the present study did not suggest any improving effect of curcumin supplementation on serum vitamin E concentrations in subjects with MetS. Copyright © 2017 John Wiley & Sons, Ltd. |
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| Keywords: | metabolic syndrome vitamin E curcuminoids turmeric |
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