| 中药多糖体内代谢和作用靶点及基于靶点的构效关系研究进展 |
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| 引用本文： | 肖芊含,王宇帆,曹蔚.中药多糖体内代谢和作用靶点及基于靶点的构效关系研究进展[J].中国现代中药,2023,25(9):2027-2036. |
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| 作者姓名： | 肖芊含 王宇帆 曹蔚 |
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| 作者单位： | 西北农林科技大学 化学与药学院，陕西 杨凌 712100 |
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| 基金项目： | 国家自然科学基金项目（81473329，81173513）；陕西省杰出青年科学基金项目（2023-JC-JQ-61） |
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| 摘 要： | 多糖是由糖苷键结合，在自然界中广泛存在的聚合碳水化合物，作为一类重要的活性天然产物受到越来越多的关注。大量研究证明，中药多糖能够被人体吸收利用，发挥抗肿瘤、免疫调节、抗氧化、降血糖等多种药理活性。近年来，随着复杂中药多糖结构的解析和作用靶点的发现，基于部分作用靶点的中药多糖构效关系被深入阐明。梳理中药多糖在体内吸收、分布、代谢与排泄进展，总结了已发现的中药多糖体内主要作用靶点及基于这些靶点的构效关系的研究新发现，并对基于分子靶点的中药多糖构效关系研究前景进行展望，以期为推动中药药效物质基础研究、促进多糖药物研发提供参考。
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| 关 键 词： | 多糖 药动学 作用靶点 构效关系 |
| 收稿时间： | 2022/12/22 0:00:00 |
Advances in the Metabolism, Pharmacological Targets, and Structure-Activity Relationship of the Polysaccharides from Chinese Herbal Medicines |
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| XIAO Qian-han,WANG Yu-fan,CAO Wei.Advances in the Metabolism, Pharmacological Targets, and Structure-Activity Relationship of the Polysaccharides from Chinese Herbal Medicines[J].Modern Chinese Medicine,2023,25(9):2027-2036. |
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| Authors: | XIAO Qian-han WANG Yu-fan CAO Wei |
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| Affiliation: | College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China |
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| Abstract: | Polysaccharides are polymeric carbohydrates with glycosidic bonds and ubiquitous in the nature. As important bioactive natural compounds, they have attracted increasing attention. Studies have proved that the polysaccharides of Chinese herbal medicines can be absorbed and utilized by the human body and exert anti-tumor, immunomodulatory, antioxidant, and blood glucose-lowering activities. In recent years, the structure-activity relationship of the polysaccharides from some Chinese herbal medicines has been clarified as the structures and the pharmacological targets of the polysaccharides have been revealed. This paper introduces the research progress in the absorption, distribution, metabolism, and excretion in vivo and the pharmacological targets of the polysaccharides from Chinese herbal medicines, and makes an outlook on the structure-activity relationship of the polysaccharides based on molecular targets, aiming to provide references for the research on the material basis of Chinese herbal medicines and the development of polysaccharide-based drugs. |
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| Keywords: | polysaccharide pharmacokinetics target structure-activity relationship |
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