| 长链非编码RNA在结直肠癌中的研究进展 |
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| 引用本文： | 黄东宁,梁小娜综述,陈罡审校.长链非编码RNA在结直肠癌中的研究进展[J].实用肿瘤学杂志,2015,29(3):263-266. |
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| 作者姓名： | 黄东宁 梁小娜综述 陈罡审校 |
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| 作者单位： | 1.广西医科大学第四附属医院肿瘤科/广西柳州市工人医院(柳州 545005);
2.广西医科大学第一附属医院病理科 |
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| 摘 要： | 长链非编码RNAs(Long non-coding RNAS,lncRNAs)是一类不编码蛋白质,长度大于200个核苷酸的RNA。结直肠癌的发生发展与lncRNA的异常表达密切相关。本文结合近年来国内外的文献报道,对lncRNA在结直肠癌中的表达情况及作用机制做一综述,以期为临床诊断和靶向治疗提供可能的依据。
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| 关 键 词： | 长链非编码RNA 结直肠癌 基因表达调节 作用机制 |
| 收稿时间： | 2014-12-08 |
Progress in the study of lncRNA in the colorectal cancer |
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| HUANG Dongning,LIANG Xiaona,CHEN Gang.Progress in the study of lncRNA in the colorectal cancer[J].Journal of Practical Oncology,2015,29(3):263-266. |
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| Authors: | HUANG Dongning LIANG Xiaona CHEN Gang |
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| Affiliation: | 1.Department of Oncology,The Fourth Affiliated Hospital of Guangxi Medical University&Liuzhou Worker′s Hospital,Liuzhou 545005,China;
2.Department of Pathology,The First Affiliated Hospital of Guangxi Medical University |
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| Abstract: | Long non-coding RNA(lncRNA)is a group of RNAs that exceed 200nt in length without protein coding capacity.The tumorigenesis and progression of colorectal carcinoma relate to the aberrant expression of lncRNAs closely.In this review,we summarize researches in the current status of lncRNAs in human colorectal carcinoma to provide potential evidences for future diagnosis and gene therapies. |
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| Keywords: | LncRNA Colorectal neoplasms Gene expression regulation Mechanisms |
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