| CAR-NK在实体瘤治疗中的研究进展 |
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| 引用本文： | 严 吉,' target='_blank'>,尹 刚,邓国英.CAR-NK在实体瘤治疗中的研究进展[J].现代肿瘤医学,2023,0(5):964-968. |
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| 作者姓名： | 严 吉 ' target='_blank'> 尹 刚 邓国英 |
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| 作者单位： | 1.上海市第一人民医院，上海201620;2.上海交通大学医学院，上海 200025 |
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| 摘 要： | 瘤免疫细胞治疗近年来备受瞩目。嵌合抗原受体T(chimeric antigen receptor engineered T-cell,CAR-T)细胞用于治疗血液系统恶性肿瘤已经颇见成效，但在实体瘤治疗方面却存在不足。由于具有不同于T细胞的非特异性杀伤肿瘤细胞的能力，CAR修饰的自然杀伤(nature killer,NK)细胞逐渐成为研究热点。目前，广泛的临床前研究证明了CAR-NK细胞疗法的安全性和有效性，尤其在实体瘤治疗方面，展现出了优于CAR-T细胞的应用前景。然而，CAR-NK细胞疗法仍存在一些局限性，需要进一步研究以期实现其临床转化。
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| 关 键 词： | 嵌合抗原受体 自然杀伤细胞 实体瘤 免疫治疗 |
Research advances of CAR-NK cell therapy in solid tumors |
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| YAN Ji,' target='_blank'>,YIN Gang,DENG Guoying.Research advances of CAR-NK cell therapy in solid tumors[J].Journal of Modern Oncology,2023,0(5):964-968. |
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| Authors: | YAN Ji ' target='_blank'> YIN Gang DENG Guoying |
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| Affiliation: | 1.Shanghai First People's Hospital,Shanghai 201620,China;2.Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China. |
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| Abstract: | Tumor immune cell therapy has attracted much attention in recent years.Chimeric antigen receptor engineered T-cell (CAR-T) cells have been used to treat hematological malignancies with great success,but there are shortcomings in the treatment of solid tumors.Due to their ability to kill tumor cells differently from T cells,CAR-modified nature killer (NK) cells have gradually become a research hotspot.At present,extensive preclinical studies have proved the safety and efficacy of CAR-NK cell therapy,especially in the treatment of solid tumors,showing better application prospects than CAR-T cells.However,CAR-NK cell therapy still has some limitations,and further research is needed to achieve its clinical translation. |
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| Keywords: | chimeric antigen receptor natural killer cells solid tumors immunotherapy |
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