| 多发性骨髓瘤中表观遗传学修饰的研究进展 |
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| 引用本文： | 阿纳尔,贾国荣.多发性骨髓瘤中表观遗传学修饰的研究进展[J].现代肿瘤医学,2022,0(21):4000-4004. |
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| 作者姓名： | 阿纳尔 贾国荣 |
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| 作者单位： | 包头医学院第一附属医院血液科，内蒙古 包头 014010 |
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| 基金项目： | 内蒙古自治区高等学校科学技术研究项目（编号:NJZY21075） |
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| 摘 要： | 多发性骨髓瘤(multiple myeloma,MM)是一种病因不明,目前仍无法治愈的恶性血液系统性疾病。研究显示MM是一种复杂的表观遗传学修饰所驱动的恶性肿瘤,表观遗传学修饰是改变MM发病进展的重要机制,并影响治疗及预后。本文将对表观遗传学异常调控在MM的发生发展过程中的作用及相关耐药机制和治疗的现状进行综述。
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| 关 键 词： | 多发性骨髓瘤 表观遗传学 DNA甲基化 组蛋白修饰 非编码RNA |
Research progress of epigenetic modification in multiple myeloma |
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| Anaer,JIA Guorong.Research progress of epigenetic modification in multiple myeloma[J].Journal of Modern Oncology,2022,0(21):4000-4004. |
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| Authors: | Anaer JIA Guorong |
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| Affiliation: | Department of Hematology,the First Affiliated Hospital of Baotou Medical College，Inner Mongolia Baotou 014010,China. |
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| Abstract: | Multiple myeloma(MM) is a malignant hematological disease with unknown etiology and still incurable.Studies have shown that MM is a malignant tumor driven by complex epigenetic modifications.Epigenetic modifications are an important mechanism that changes the pathogenesis and progression of MM,and affects treatment and prognosis.This article will review the role of abnormal epigenetics in the occurrence and development of MM and the current status of related drug resistance mechanisms and treatments. |
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| Keywords: | multiple myeloma epigenetics DNA methylation histone modification non coding RNA |
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