| 外周血NLR和PLR评估晚期非小细胞肺癌一线含铂双药化疗疗效和预后的价值 |
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| 引用本文： | 徐小峰,戴宏宇,乔建兵,夏春伟.外周血NLR和PLR评估晚期非小细胞肺癌一线含铂双药化疗疗效和预后的价值[J].现代肿瘤医学,2020,0(15):2627-2631. |
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| 作者姓名： | 徐小峰 戴宏宇 乔建兵 夏春伟 |
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| 作者单位： | 南京市胸科医院呼吸内科，江苏 南京 210029 |
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| 摘 要： | 目的:探讨化疗前外周血NLR和PLR与晚期NSCLC患者接受一线含铂双药化疗疗效和预后的相关性。方法:选取在我院确诊的初治晚期NSCLC患者230例，计算化疗前NLR和PLR，并根据ROC曲线图计算其截断值。分析NLR和PLR与NSCLC临床病理特征的关系。分别比较各组患者中位生存时间的差异；采用单因素及多因素 Logistic 回归对预后因素进行分析。结果:根据ROC曲线计算NLR和 PLR临界值分别为:4.5和235。外周血PLR与治疗反应显著相关（P<0.05），而NLR与治疗反应无明显相关（P>0.05）。高NLR组和低NLR组OS分别为:11个月和15.8个月（P<0.001）；高PLR组和低PLR组OS分别为:12个月和15.2个月（P<0.001）。单因素和多因素结果显示，NLR和PLR是晚期NSCLC预后的独立影响因素。结论:外周血PLR一定程度上可预测化疗反应，NLR和PLR是晚期NSCLC预后的独立影响因素，治疗前评估NLR和PLR可以判断晚期NSCLC患者的预后。
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| 关 键 词： | 中性粒细胞与淋巴细胞比值 血小板与淋巴细胞比值 非小细胞肺癌 预后 |
Effect of the NLR and PLR on the response of first line platinum-based chemotherapy and the prognosis in advanced NSCLC |
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| Xu Xiaofeng,Dai Hongyu,Qiao Jianbing,Xia Chunwei.Effect of the NLR and PLR on the response of first line platinum-based chemotherapy and the prognosis in advanced NSCLC[J].Journal of Modern Oncology,2020,0(15):2627-2631. |
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| Authors: | Xu Xiaofeng Dai Hongyu Qiao Jianbing Xia Chunwei |
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| Affiliation: | Department of Respiratory，Nanjing Chest Hospital，Jiangsu Nanjing 210029，China. |
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| Abstract: | Objective:To investigate the correlation between neutrophil-lymphocyte ratio(NLR)，platelet-to-lymphocyte ratio(PLR） and the response to first-line chemotherapy and prognosis in patients with advanced NSCLC.Methods:A retrospective analysis was performed on 230 advanced NSCLC patients in Nanjing Chest Hospital.Pre-treatment NLR and PLR were calculated by division of neutrophils and platelets by lymphocytes.ROC curves were used to define the optimal cutoff of NLR and PLR.The association between NLR，PLR and pathological characteristics were analyzed.Cox regression analyses were conducted to study the prognostic role of NLR and PLR on OS.The prognosis were analyzed by univariate and multivariate regression.Results:The optimal cutoffs of the NLR and the PLR were 4.5 and 235，respectively.PLR was significantly correlated with the response of first line chemotherapy.The median survival time(OS） for patients with high NLR and low NLR was 11 months and 15.8 months，respectively.The OS for patients with hgih PLR and low PLR was 12 months and 15.2 months.Multivariate analysis showed NLR and PLR were independent prognostic factors for NSCLC patients.Conclusion:PLR was well associated with the response to first line chemotherapy in patients with advanced NSCLC.NLR and PLR are risk factors influencing the prognosis of advanced NSCLC. |
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| Keywords: | NLR PLR NSCLC prognosis |
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