| COPD相关性腺癌与鳞癌基因遗传差异的研究进展 |
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| 引用本文： | 方启宇,邓沁芳,孟淑燕,周崧雯.COPD相关性腺癌与鳞癌基因遗传差异的研究进展[J].现代肿瘤医学,2018,0(6):975-979. |
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| 作者姓名： | 方启宇 邓沁芳 孟淑燕 周崧雯 |
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| 作者单位： | 同济大学附属上海市肺科医院肿瘤科，上海 200433 |
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| 摘 要： | 在世界范围内，肺癌是癌症死亡的主要原因。其中非小细胞肺癌占85%，主要病理类型为腺癌和鳞癌。研究提示COPD独立于吸烟，为其高危因素。相同的致病因子作用下，COPD相关性腺癌与鳞癌的差异提示，两者之间除常见的慢性炎症、氧化应激、免疫应答等机制外，还存在不同的基因遗传机制。本文就COPD相关性腺癌和COPD相关性鳞癌基因遗传关系的研究进展作一综述。
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| 关 键 词： | 慢性阻塞性肺病 腺癌 鳞癌 基因 |
Research progress on genetic diversity of COPD-related adenocarcinoma and COPD-related squamous cell carcinoma |
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| Fang Qiyu,Deng Qinfang,Meng Shuyan,Zhou Songwen.Research progress on genetic diversity of COPD-related adenocarcinoma and COPD-related squamous cell carcinoma[J].Journal of Modern Oncology,2018,0(6):975-979. |
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| Authors: | Fang Qiyu Deng Qinfang Meng Shuyan Zhou Songwen |
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| Affiliation: | Department of Medical Oncology,Shanghai Pulmonary Hospital,Tongji University School of Medicine,Shanghai 200433,China. |
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| Abstract: | Lung cancer is the leading cause of death from cancer worldwide,where non-small-cell lung cancers(NSCLCs) represent 85% of all lung cancers.Independent of smoking,chronic obstructive pulmonary disease(COPD) patients have an increased risk of NSCLCs which consist of adenocarcinoma and squamous cell carcinoma primarily.According to the distinction between COPD-related adenocarcinoma and COPD-related squamous cell carcinoma,genetic mechanism plays an important role in the development besides common causes as chronic inflammation,oxidative stress,immune response mechanism in the same causative agent.This review describes the current understanding of the difference between COPD-related adenocarcinoma and COPD-related squamous cell carcinoma from a genetical perspective. |
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| Keywords: | chronic obstructive pulmonary disease(COPD) adenocarcinoma squamous cell carcinoma genetics |
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