| 放疗分别联合多西他赛、顺铂、替吉奥治疗局部晚期鼻咽癌的疗效比较 |
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| 引用本文： | 鲜 枫,胡 欣,张 倩,文世民,谢 忠,潘荣强.放疗分别联合多西他赛、顺铂、替吉奥治疗局部晚期鼻咽癌的疗效比较[J].现代肿瘤医学,2019,0(16):2852-2855. |
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| 作者姓名： | 鲜 枫 胡 欣 张 倩 文世民 谢 忠 潘荣强 |
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| 作者单位： | 南充市中心医院肿瘤防治中心,四川 南充 637000 |
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| 基金项目： | 四川省教育厅科研计划(编号:18ZB0214) |
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| 摘 要： | 目的:比较多西他赛(TXT)、顺铂(DDP)、替吉奥（S-1）同步放疗治疗晚期鼻咽癌的近期疗效和毒副反应。方法:将99例晚期鼻咽癌患者分为TXT组、DDP组及S-1组,各33例。治疗方案:TXT 25 mg/m2静滴,每周1次；DDP 40 mg/m2静滴,每周1次；S-1 40 mg/m2口服，2次/日，d1~14，21天为1周期，共2~3周期。同步IGRT放疗,鼻咽靶区剂量（69.96~73.92） Gy/33 f。评价近期疗效及毒副反应。结果:99例患者均可评价疗效。TXT组CR 20例、PR 11例、SD 2例,RR为93.9%;DDP组CR 21例、PR 10例、SD 2例,RR为93.9%；S-1组CR 18例、PR 12例、SD 3例,RR为90.9%。DDP组与TXT组间疗效无统计学差异(P＞0.05)，S-1组在疗效上稍差于DDP组及TXT组（P＜0.05）。主要毒副反应有中性粒细胞减少、胃肠道反应、放射性皮炎及口腔黏膜炎。DDP组中性粒细胞减少和口腔黏膜炎发生率明显高于TXT组(P＜0.05)，S-1组中性粒细胞减少和口腔黏膜炎发生率明显低于TXT组（P＜0.05）；胃肠道反应发生率依次为DDP组＞S-1组＞TXT组（P＜0.05）。结论:TXT同步放疗治疗晚期鼻咽癌的近期疗效好,且毒副作用小,可作为晚期鼻咽癌治疗的新选择。
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| 关 键 词： | 多西他赛 顺铂 替吉奥 同步放疗 鼻咽癌 |
Comparison of radiotherapy respectively combined with docetaxel,cisplatin,or S-1 in the treatment of locally advanced nasopharyngeal carcinoma |
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| Xian Feng,Hu Xin,Zhang Qian,Wen Shimin,Xie Zhong,Pan Rongqiang.Comparison of radiotherapy respectively combined with docetaxel,cisplatin,or S-1 in the treatment of locally advanced nasopharyngeal carcinoma[J].Journal of Modern Oncology,2019,0(16):2852-2855. |
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| Authors: | Xian Feng Hu Xin Zhang Qian Wen Shimin Xie Zhong Pan Rongqiang |
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| Affiliation: | Cancer Prevention Center,Nanchong Central Hospital,Sichuan Nanchong 637000,China. |
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| Abstract: | Objective:To investigated the short-term efficacy and side effects of docetaxel (TXT) concurrent radiotherapy,cisplatin (DDP) concurrent radiotherapy and tigeolone (S-1) concurrent radiotherapy for advanced nasopharyngeal carcinoma.Methods:99 patients with advanced nasopharyngeal carcinoma were divided into TXT group,DDP group and S-1 group,with 33 cases in each group.The TXT group was specifically:TXT 25 mg/m2 intravenous infusion,once a week for 7 times.The DDP group was specifically:DDP 40 mg/m2 intravenous infusion,once a week for 7 times.The S-1 group was specifically:S-1 40 mg/m2 orally,2 times/day,d1~14,21 days for 1 cycle,a total of 2~3 cycles.Radiation therapy was performed with IGRT and the dose of nasopharyngeal target area (69.96~73.92) Gy/33 f.According to the solid tumor efficacy evaluation standard RECIST 1.1,the short-term efficacy was evaluated and the effective rate (RR) was calculated,and the NCI CTC 3.0 standard was used to evaluate the toxic side reaction.Results:99 patients were able to evaluate the efficacy.The TXT group received 20 cases of CR,11 cases of PR and 2 cases of SD,with an RR of 93.9%.The DDP group received 21 cases of CR,10 cases of PR and 2 cases of SD,with an RR of 93.9%.The S-1 group received 18 cases of CR,12 cases of PR,SD 3 cases,and RR was 90.9%.The difference of RR among the three groups was statistically significant (P＜0.05).There was no significant difference between the DDP group and the TXT group (P＞0.05).The S-1 group was slightly worse than the DDP group and the TXT group (P＜0.05).The major toxic side effects included neutropenia,gastrointestinal reactions,radiation dermatitis,and oral mucositis.The incidence of neutropenia and oral mucositis in the DDP group was significantly higher than that in the TXT group (P＜0.05).The incidence of neutropenia and oral mucositis in the S-1 group was significantly lower than that in the TXT group (P＜0.05).In the incidence of gastrointestinal reactions,DDP group was higher than and S-1 group,S-1 group was higher than TXT group (P＜0.05).Conclusion:TXT synchronous radiotherapy has a short-term effect on advanced nasopharyngeal carcinoma with small side effects and can be used as a new treatment for advanced nasopharyngeal carcinoma. |
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| Keywords: | docetaxel cisplatin S-1 synchronous radiotherapy nasopharyngeal carcinoma |
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