| ERCC1在结直肠癌组织中的表达及预后价值 |
| |
| 引用本文： | 区宝琦,赵 勇,荣 枫,严 伟.ERCC1在结直肠癌组织中的表达及预后价值[J].现代肿瘤医学,2019,0(3):447-451. |
| |
| 作者姓名： | 区宝琦 赵 勇 荣 枫 严 伟 |
| |
| 作者单位： | 安徽医科大学附属六安医院肿瘤外科，安徽 六安 237000 |
| |
| 基金项目： | 卫生部医药卫生科技发展研究中心课题(编号:W2012FZ140) |
| |
| 摘 要： | 目的:探究核苷酸切除修复交叉互补基因1（excision repair cross-complementation gene 1，ERCC1）表达对结直肠癌（colorectal cancer，CRC）患者铂类辅助化疗的预后价值。方法:选取2011年01月至2013年01月安徽医科大学附属六安医院行CRC根治术后接受mFOLFOX6方案化疗的患者共84例，通过免疫组化方法评估ERCC1在CRC组织中表达情况，分析ERCC1表达与预后的关联。结果:ERCC1高表达30例（35.7%）。Kaplan-Meier曲线显示ERCC1高表达的CRC患者无病生存期（DFS）和总生存期（OS）均缩短（P均<0.001）。多因素COX分析显示ERCC1高表达（DFS HR=4.645，95%CI:2.045~10.548，P<0.001；OS HR=4.898，95%CI:1.971~12.170，P<0.001）是CRC患者预后的不良因素，分析各亚组患者中ERCC1表达与生存相关性得到相似的结果。复发患者中ERCC1高表达的肝肺转移占68.8%（11/16），低表达的腹腔转移为70.0%（7/10），ERCC1表达与首次复发模式显著相关（P=0.006）。结论:ERCC1表达可作为评价CRC患者预后的重要指标。ERCC1表达可能有助于预测CRC患者辅助化疗后首次复发模式。ERCC1表达的预后价值需进一步研究。
|
| 关 键 词： | 结直肠癌 ERCC1 辅助化疗 预后 |
The expression and prognostic value of ERCC1 in colorectal cancer tissues |
| |
| Ou Baoqi,Zhao Yong,Rong Feng,Yan Wei.The expression and prognostic value of ERCC1 in colorectal cancer tissues[J].Journal of Modern Oncology,2019,0(3):447-451. |
| |
| Authors: | Ou Baoqi Zhao Yong Rong Feng Yan Wei |
| |
| Affiliation: | Department of Oncology，Lu'an Hospital Affiliated to Anhui Medical University，Anhui Lu'an 237000，China. |
| |
| Abstract: | Objective:To explore the prognostic value of nucleotide excision repair cross-complementation gene 1 (ERCC1) expression in patients receiving oxaliplatin adjuvant chemotherapy with colorectal cancer (CRC).Methods:A total of 84 patients undergoing mFOLFOX6 chemotherapy after radical resection of CRC from Lu'an Hospital Affiliated to Anhui Medical University from January 2011 to January 2013 were selected.The expression of ERCC1 in CRC tissues was evaluated by immunohistochemistry and the correlation between ERCC1 expression and prognosis was analyzed.Results:ERCC1 was highly expressed in 30 patients (35.7%).Kaplan-Meier curves showed a reduction in disease-free survival (DFS) and overall survival (OS) in CRC patients with high ERCC1 expression (P<0.001).Multivariate COX analysis showed that high expression of ERCC1 (DFS HR=4.645，95%CI:2.045~10.548，P<0.001.OS HR=4.898，95%CI:1.971~12.170，P<0.001) was a poor prognostic factor.Analysis of the correlation between ERCC1 expression and survival in similar subgroups was similar.Among the 16 patients with high expression and recurrence of ERCC1，liver and lung metastasis was 68.8% (11/16).In 10 patients with low expression of ERCC1 and recurrence，70.0% (7/10) of the patients had peritoneal metastasis.ERCC1 expression was significantly associated with the first recurrence pattern (P=0.006).Conclusion:ERCC1 expression can be used as an important indicator to evaluate the prognosis of CRC patients and may help predict the first relapse pattern after adjuvant chemotherapy in CRC patients.The prognostic value of ERCC1 expression needs further study. |
| |
| Keywords: | colorectal cancer ERCC1 adjuvant chemotherapy prognosis |
|
| 点击此处可从《现代肿瘤医学》浏览原始摘要信息 |
|
点击此处可从《现代肿瘤医学》下载全文 |
