| 大肠癌中αvβ3 integrin表达与血管生成拟态的关系及分子机制的研究 |
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| 引用本文： | 庞春光,孙保存,赵秀兰,刘志勇,古强,董学易,马跃美,孙丹.大肠癌中αvβ3 integrin表达与血管生成拟态的关系及分子机制的研究[J].中国肿瘤临床,2013,0(10):555-559. |
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| 作者姓名： | 庞春光 孙保存 赵秀兰 刘志勇 古强 董学易 马跃美 孙丹 |
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| 作者单位： | ①.天津医科大学病理教研室（天津市300070） |
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| 基金项目： | 国家自然科学基金重点项目81230050天津市科委重点项目10JCZDJC20400 |
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| 摘 要： | 目的 探讨大肠癌中是否存在血管生成拟态（VM）, 阐述VM存在的临床意义; 分析VM与αvβ3 integrin表达的关系; 研究大肠癌中αvβ3 integrin表达的临床意义及其与FAK、MMP-2、VEGF表达的相关性。 方法 对227例大肠癌组织切片进行CD31免疫组织化学和PAS染色及αvβ3 integrin、FAK、VEGF、MMP-2免疫组织化学染色。 结果 VM在大肠癌中阳性率为18.06%（41/ 227）, αvβ3 integrin在大肠癌中阳性率为56.83%（129/227）; VM阳性组、αvβ3 integrin阳性组生存时间均较阴性组短, 差异均有统计学意义（P < 0.05）; VM阳性组的αvβ3 integrin阳性率较阴性组高, 差异有统计学意义（P < 0.05）; αvβ3 integrin与FAK、VEGF、MMP-2表达呈正相关。 结论 大肠癌中VM的存在、αvβ3 integrin的表达与肿瘤的不良预后有关; αvβ3 integrin可能通过与FAK、VEGF、MMP-2的相互作用, 参与了大肠癌VM的形成。
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| 关 键 词： | 大肠癌 血管生成拟态 αvβ3 integrin 表达 临床预后 |
| 收稿时间： | 2013-02-20 |
Relationship betweenαvβ3 integrin and vasculogenic mimicry ex-pression and related molecular mechanisms |
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| Affiliation: | ①.Department of Pathology, Tianjin Medical University, Tianjin, 300070②.Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China |
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| Abstract: | Objective This work aimed to investigate the expression and clinical significance of vasculogenic mimicry (VM), toanalyze the relationship between VM and αvβ3 integrin expressions, and to study the clinical significance of αvβ3 integrin expressionand its correlation with the Focal Adhesion Kinase (FAK), Vascular Endothelial Growth Factor (VEGF), and Matrix Metalloproteinase2 (MMP-2) expression. Methods VM expression was observed by CD31 immunohistochemical and PAS staining. Expression of αvβ3integrin, FAK, VEGF, and MMP-2 was observed by immunohistochemical staining. Results Results showed that VM and αvβ3 integrinhad positive rates of 18.06% (41/227) and 56.83% (129/227), respectively. Patients with VM expression had a shorter survival timethan those without VM expression (P < 0.05). αvβ3 integrin-positive patients had a shorter survival time than αvβ3 integrin-negative patients(P < 0.05). Patients with VM expression showed a higher positive rate of αvβ3 integrin than those without VM expression (P < 0.05), and αvβ3 integrin had a positive correlation with FAK, MMP-2, and VEGF expression. Conclusion The incidence of VM and αvβ3 integrin expressions in human colorectal cancer cases indicates a poor prognosis. αvβ3 integrin possibly participates in the formationof VM through interactions with FAK, VEGF, and MMP-2. |
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| Keywords: | colorectal cancer vasculogenic mimicry αvβ3 integrin molecular mechanism clinical prognosis |
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