| UbcH10与肿瘤关系研究进展 |
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| 引用本文： | 韩少山,孙昊.UbcH10与肿瘤关系研究进展[J].中国肿瘤临床,2011,38(14):867-869. |
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| 作者姓名： | 韩少山 孙昊 |
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| 作者单位： | 西安交通大学医学院第一附属医院肝胆外科 (西安市710061) |
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| 基金项目： | 本文课题受陕西省科技攻关项目基金 |
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| 摘 要： | 泛素-蛋白酶体系统（UPS）是蛋白质选择性降解的最重要机制之一。蛋白质的泛素化是一个非常复杂而缜密的级联酶促反应过程，参与调节细胞内多种蛋白的表达水平和功能活性。泛素-蛋白酶体系统的异常与恶性肿瘤的发生和进展有着密切的关系。泛素偶联酶UbcH10属于泛素偶联酶E2家族，其与特定的E3酶相互作用引起底物蛋白的降解，是一种参与细胞有丝分裂调控的细胞周期蛋白。UbcH10可激活Cdc20/APC，与细胞周期进展、细胞分裂、染色体分离密切相关。UbcH10表达异常可导致细胞的染色体不稳定，细胞分裂异常。目前已有研究证明UbcH10是一种具有癌基因性质的泛素偶联酶。UbcH10在乳腺癌、结肠癌、胃癌、卵巢癌、肝癌、脑胶质瘤、淋巴瘤等多种肿瘤中高表达并且与肿瘤分期呈正相关，提示不良预后，可能成为新的肿瘤标志物或治疗靶点。本文就近年来关于UbcH10在肿瘤中作用的研究进展加以综述。
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| 关 键 词： | UbcH10 泛素蛋白酶体系统 肿瘤 |
| 收稿时间： | 2011-03-03 |
Research Advances in UbcH10 and Its Relationship with Cancer |
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| Shaoshao HAN,HAO SUN.Research Advances in UbcH10 and Its Relationship with Cancer[J].Chinese Journal of Clinical Oncology,2011,38(14):867-869. |
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| Authors: | Shaoshao HAN HAO SUN |
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| Affiliation: | Department of Hepatobiliary Surgery, First Affiliated Hospital of School of Medicine, Xi’an Jiao Tong University, Xi’an 710061, China |
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| Abstract: | The ubiquitin-proteasome system (UPS) is one of the most important mechanisms of selective protein degradation. Ubiquitination is a highly ordered, multistep enzymatic process carried out by a well-defined systematic ubiquitin pathway, which is necessary in maintaining the appropriate levels and functional activities of various cellular proteins. Abnormality in UPS is highly related to the development and progression of malignant tumors. UbcH10, an E2 protein catalyzing the E3-dependent multiple ubiqutination leading to proteolysis of substrate proteins, is a cell cycle-related protein involved in mitosis completion. UbcH10 can activate Cdc20/APC and plays an important role in cell cycle progression, cell mitosis, and chromosome segregation. Aberrant expression of UbcH10 impairs the spindle assembly checkpoint, potentially inducing chromosomal instability and aneuploidy. UbcH10 is significantly overexpressed in carcinomas of the breast, gastric, ovary, and liver, as well as in glioblastomas. It is also associated with the degree of tumor differentiation and poor prognosis. UbcH10 may act as a novel biomarker and can be a therapeutic target in cancer patients. In the current review, we summarize the most recent data on UbcH10 and its relationship with cancer. |
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| Keywords: | UbcH10 |
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