| MMP-9 在胃癌及其淋巴结组织中表达的临床意义* |
| |
| 引用本文： | 姬瑞,周永宁,任涛文,张志镒,李强.MMP-9 在胃癌及其淋巴结组织中表达的临床意义*[J].中国肿瘤临床,2010,37(7):377-380. |
| |
| 作者姓名： | 姬瑞 周永宁 任涛文 张志镒 李强 |
| |
| 作者单位： | 作者单位:兰州大学第一医院消化内科(兰州市730000);①甘肃省武威肿瘤医院 |
| |
| 摘 要： | 目的:研究MMP-9 在胃癌组织中的表达状况，分析其与临床病理特征和生存之间的关系。方法:应用免疫组化SP法，采用组织芯片技术，分析189 例胃癌、54例癌旁组织、41例淋巴结转移灶及32例正常对照组织中c-Jun 和MMP-9 蛋白表达。结果:胃癌中MMP-9 蛋白的阳性表达率为78.3% 。MMP-9 的表达与浸润深度、淋巴结转移、分化程度及Lauren 分型有关（P<0.05）。 41例淋巴结转移灶和相对应的41例胃癌组织各因子表达比较发现，MMP-9 阳性表达率具有显著性差异（P<0.05）。 与MVD进行比较发现，MMP-9 阳性患者的MVD值高于阴性组，差异有统计学意义（P<0.05）。 单因素生存分析显示MMP-9 阳性组对胃癌患者生存期的影响有统计学意义（P<0.05），Cox 多因素回归分析显示MMP-9 的异常表达不能作为影响胃癌预后的独立因素（P>0.05）。 结论:MMP-9 在胃癌组织中均有高表达。MMP-9 阳性表达与肿瘤的浸润、转移密切相关，可作为判断胃癌恶性行为的重要生物学标记物。MMP-9 在促进血管生成中起重要作用。MMP-9 蛋白阳性表达对胃癌患者来说是一个不利的预后因素，但尚不能作为一个独立的预后指标。
|
| 关 键 词： | 胃癌 MMP-9 临床病理学 微血管密度 生存期 异质性 |
| 收稿时间： | 2009-08-28 |
Expression and Clinical Significance of MMP-9 in Gastric Cancer and Metastatic Lymph Nodes |
| |
| Affiliation: | 1Department of Gastroenterology of The First Hospital of Lanzhou University, Lanzhou 730000, China |
| |
| Abstract: | 0bjective:To investigate the expression of MMP-9 in gastric cancer,para-cancerous tissue and metastastic lymph nodes and to explore its relationship with the clinicopathologic features and prognosis.Methods:Immunohistochemis-try was used to detect the expression of MMP-9 on tissue microarray containing gastric normal mucosa(n=32),para-can-cerous tissue(n=54),metastastic lymph nodes(n=41),and gastric cancer tissue(n=189).Results:The positive rate of MMP-9 expression was 78.3% in gastric cancer tissues.The positive rate of MMP-9 expression was associated with depth of invasion,lymph node metastasis,Lauren type and degree of differentiation(P<0.05),but was not associated with sex,age,or tumor size(P>0.05).There was a significant difference in MMP-9 expression between gastric cancer tissues and metastastic lymph nodes(P<0.05).In metastastic lymph nodes,the positive rate of MMP-9 expression was higher.The MVD in MMP-9 positive tissues tended to be greater than that in MMP-9 negative tissues,with a statistical significance(P<0.05).Kaplan-Meier survival analysis showed that the survival of patients without MMP-9 expression was longer than those with positive MMP-9 expression(P<0.05).COX regression analysis revealed that MMP-9 expression was not an indepen-dent prognostic factor for gastric cancer.Conclusion:The higher expression of MMP-9 involves the occurrence,progres-sion,invasion,and metastasis of gastric cancer.MMP-9 can be used as a metastatic predictor and prognostic marker for gastric cancer.MMP-9 may promote angiogenesis.But MMP-9 is not an independent prognostic indicator for gastric cancer. |
| |
| Keywords: | MMP-9 Gastric cancer MMP-9 Clinicopathology MVD Survival Heterogeneity |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《中国肿瘤临床》浏览原始摘要信息 |
|
点击此处可从《中国肿瘤临床》下载全文 |
|
