| miR-17-92基因簇在骨肉瘤中的表达及其临床意义 |
| |
| 引用本文： | 林金銮,王发圣,叶君健,吴朝阳,李祥,林建华.miR-17-92基因簇在骨肉瘤中的表达及其临床意义[J].中国肿瘤临床,2014,41(23):1532-1535. |
| |
| 作者姓名： | 林金銮 王发圣 叶君健 吴朝阳 李祥 林建华 |
| |
| 作者单位： | ①.福建医科大学附属第一医院骨科(福州市 350005) |
| |
| 基金项目： | 福建省临床重点专科建设项目和福建医科大学临床医学重点学科XK201106 |
| |
| 摘 要： | 目的 探讨人骨肉瘤组织和邻近正常骨组织中miR-17-92基因簇的表达情况及其临床意义。 方法 运用Q-PCR法检测63例骨肉瘤组织及邻近部位正常骨组织中miR-17-92基因簇的表达水平, 并分析miR-17-92基因簇表达与患者临床病理特征及预后的关系。 结果 miR-17-92在所有组织中均有表达, 且在肿瘤组织中表达明显高于在正常组织中的表达(P < 0.05), 另外, miR-17-92基因簇高表达患者预后更差, 差异有统计学意义(P=0.027)。 结论 miR-17-92基因簇在骨肉瘤组织和邻近正常骨组织中表达存在差异性, 可能在骨肉瘤发生、发展过程中起重要作用, 有望成为骨肉瘤患者预后一种新的指标。
|
| 关 键 词： | miR-17-92基因簇 骨肉瘤 预后 |
| 收稿时间： | 2014-08-01 |
Expression of miR-17-92 cluster in osteosarcoma and its clinical significance |
| |
| Affiliation: | ①.Department of Orthopedics, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005②.Department of Orthopedics, Zhejiang Taizhou No.1 People's Hospital, Taizhou 318000, China |
| |
| Abstract: | Objective To determine the expression of miR-17-92 cluster in osteosarcoma tissue samples and explore its association with clinical significance. Methods Quantitative polymerase chain reactiom analysis was used to examine the expression of miR-17-92 cluster in osteosarcoma tissues.Normal bone tissues from 63 patients were matched, and the relationships between the expression of miR-17-92 cluster and the clinicopathological features and prognosis of osteosarcoma were explored. Results The relative expression of miR-17-92 cluster in osteosarcoma tissues was significantly higher than those in adjacent normal tissues (P < 0.05).The high expression of miR-17-92 had a significant correlation with reduced survival (P=0.027). Conclusion The expression of miR-17-92 cluster closely correlates with the occurrence and progress of osteosarcoma and may be used as an indicator for osteosarcoma prognosis. |
| |
| Keywords: | |
|
| 点击此处可从《中国肿瘤临床》浏览原始摘要信息 |
|
点击此处可从《中国肿瘤临床》下载全文 |
|
