| TNF-α 基因308 位点单核苷酸多态性与原发性肺癌相关性研究* |
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| 引用本文： | 孙永林①,李颖②,李永文②,吴志浩②,范亚光②,刘红雨②,陈军①.TNF-α 基因308 位点单核苷酸多态性与原发性肺癌相关性研究*[J].中国肿瘤临床,2015,42(15):733-736. |
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| 作者姓名： | 孙永林① 李颖② 李永文② 吴志浩② 范亚光② 刘红雨② 陈军① |
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| 作者单位： | 作者单位:①天津医科大学总医院肺部肿瘤外科(天津市300052);②天津市肺癌研究所,天津市肺癌转移与肿瘤微环境实验室 |
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| 摘 要： | 目的:肿瘤坏死因子- α（tumor necrosis factor- α ，TNF-α）基因启动子单核苷酸多态性与某些炎性疾病、肿瘤的发生有关。本研究就TNF-α - 308G/A 位点基因多态性与中国人群原发性肺癌易感性进行探讨。方法:应用高通量TaqMan-MGB 探针技术对TNF-α - 308G/A 位点，即rs 1800629 位点进行基因分型，分析比较447 例健康对照者和250 例原发性肺癌患者的基因类型。采用SPSS18.0 软件对数据资料进行统计分析。结果:TNF-α - 308G/A 位点GG基因型在病例组和对照组中的频率分别为73.2%和90.8% 。A/G 基因型在病例组和对照组中频率分别为26.8% 和8.7% 。基因型A/G+AA频率分别为26.8% 和9.2% ，该位点多态性在病例组和对照组中的分布频率差异具有统计学意义（P < 0.05）。 此外，A/G 基因型在男性、吸烟、小细胞肺癌或非小细胞肺癌患者相对于GG型均为危险因素，但在女性中无统计学意义（P > 0.05）。 结论:TNF-α - 308G/A 位点基因多态性与中国原发性肺癌发病易感性显著相关。
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| 关 键 词： | 肿瘤坏死因子- α 基因 单核苷酸多态性 原发性肺癌 小细胞肺癌 非小细胞肺癌 |
| 收稿时间： | 2015-05-15 |
Association between TNF-α -308 genetic polymorphisms and increased risk of primary lung cancer in Chinese population: a case-control study |
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| Affiliation: | 1Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin300052, China; |
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| Abstract: | Objective:Previous studies suggested that the - 308G/A allele in the tumor necrosis factor- α (TNF- α ) gene promoter (- 308G/A) may be a potential risk factor for inflammatory diseases and tumor progression. However, only a few studies have focused on the -308 polymorphism of TNF-α gene with primary lung cancer in Chinese population. This study aims to evaluate the role of TNF-α - 308G/A single nucleotide polymorphism (SNP) and the risk of primary lung cancer in Chinese population. Methods:A total of 250 patients and 447 healthy individuals (control group) were involved in this study. Genotyping was performed using TaqMan technology. Results: The frequencies of (GG), (A/G), and (A/G+AA) genotypes of -308G/A SNP in TNF-α gene were183 (73.2%),67(26.8%), and 67(26.8%) in the patients, and406 (90.8%),39(8.7%), and41(9.2%) in the control group, respectively. The distribution of poly-morphism frequencies in the case group and the control group showed a statistically significant difference for the Chinese population (P<0.05). Conclusion:Results indicated that TNF-α gene polymorphism at position -308G/A is associated with susceptibility to lung cancer in Chinese Han population. |
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