| 鼻咽癌自适应放疗研究进展 |
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| 引用本文： | 程金建.鼻咽癌自适应放疗研究进展[J].中国肿瘤临床,2013,40(20):1272-1275. |
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| 作者姓名： | 程金建 |
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| 作者单位： | ①.广西壮族自治区人民医院肿瘤中心放疗科（南宁市530021） |
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| 基金项目： | 本文课题受国家自然科学基金项目 |
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| 摘 要： | 调强放疗（intensity-modulated radiotherapy，IMRT）正逐步取代传统放疗成为鼻咽癌（nasopharyngeal carcinoma，NPC）的主流根治手段，既能提高肿瘤相关区域放疗剂量，又能降低正常器官和组织的受照剂量和体积，具有明显优势。但IMRT过程中，除系统误差和摆位误差外，鼻咽原发病灶和颈部转移淋巴结逐渐缩小、患者体质量逐渐减轻及体表外轮廓逐渐改变，也可导致NPC靶区和重要器官的照射剂量和体积出现“偏差”，影响IMRT的精确性。不少学者采用自适应放疗（adaptive radiotherapy，ART）修正鼻咽癌IMRT过程中由于肿瘤缩小、体质量减轻和外轮廓改变产生的“偏差”，结果显示ART具有一定的可行性，能够修正部分由肿瘤、体质量和外轮廓变化导致的“偏差”。
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| 关 键 词： | 鼻咽癌 调强放疗 自适应放疗 再次计划 |
| 收稿时间： | 2013-01-23 |
Advances in research on adaptive radiotherapy for nasopharyn-geal carcinoma |
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| Jinjian CHENG
,
Hua YANG
,
Zhiping LU
,
Heming LU
,
Yanrong HAO
,
Jiaxin CHEN.Advances in research on adaptive radiotherapy for nasopharyn-geal carcinoma[J].Chinese Journal of Clinical Oncology,2013,40(20):1272-1275. |
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| Authors: | Jinjian CHENG Hua YANG Zhiping LU Heming LU Yanrong HAO Jiaxin CHEN |
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| Affiliation: | ①.Department of Radiation Oncology, Cancer Center, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China②.Department of Drug Toxicity, School of Pharmaceutical Sciences, Guangxi Medical University, Nanning 530021, China |
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| Abstract: | Intensity-modulated radiotherapy (IMRT) is gradually replacing conventional radiation therapy and has become the mainstream radical treatment for patients with nasopharyngeal carcinoma (NPC). IMRT can conform and increase radiation doses to tumor-associated regions as well as decrease exposure doses and volumes on normal organs and tissues to avoid damage on critical organs. Aside from system and setup errors, other factors, such as the gradual reduction of the primary NPC lesion and the decrease in volume of involved neck lymph nodes as well as body weight loss and changes in the head and neck shape during IMRT, may cause deviations in the radiation doses and volume delivered to the NPC targets and the organs at risk. These factors may affect the accuracy of IMRT. Several researchers have attempted to correct such deviations during IMRT for NPC patients by using adaptive radiotherapy (ART). The results indicate that ART is feasible to a certain degree and can correct the deviations, including decrease in tumor volume, body weight loss, and changes in head and neck shape of NPC patients. |
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| Keywords: | nasopharyngeal carcinoma intensity-modulated radiotherapy adaptive radiotherapy replanning |
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