| 山西和河南省部分地区人群流行性乙型脑炎病毒中和抗体水平调查 |
| |
| 引用本文： | 付士红,尹遵栋,高晓艳,王环宇,翟如芳,张彦平,孟维珊,邹文菁,吕志,唐晓燕,陈淑珍,汤伯明,姚海威,王泽义,常少英,梁少林,梁晓峰,梁国栋.山西和河南省部分地区人群流行性乙型脑炎病毒中和抗体水平调查[J].疾病监测,2010,25(2):99-102. |
| |
| 作者姓名： | 付士红 尹遵栋 高晓艳 王环宇 翟如芳 张彦平 孟维珊 邹文菁 吕志 唐晓燕 陈淑珍 汤伯明 姚海威 王泽义 常少英 梁少林 梁晓峰 梁国栋 |
| |
| 作者单位： | 1.中国疾病预防控制中心病毒病预防控制所,北京 100052; |
| |
| 摘 要： | 目的调查山西和河南省部分地区健康人群血清中流行性乙型脑炎(乙脑)病毒中和抗体水平。方法对采集的血清标本按1:10,1:20,1:40,1:80四个稀释度稀释后进行乙脑病毒中和试验,结果判定采用细胞病变观察方法并结合ELISA测定结果进行综合判定。结果调查结果显示,所测标本中乙脑病毒中和抗体保护率以临猗县最高(87.6%),其次是栾川县(58.2%)和万荣县(51.4%)。经χ2检验,临猗县与万荣县中和抗体保护率差异有统计学意义(χ2=42.812,P=0.000),临猗县的中和抗体保护率高于万荣县,栾川县与万荣县的中和抗体保护率差异无统计学意义(χ2=1.466,P=0.226)。两个年龄组(≤40岁和40岁)中和抗体保护率比较显示,临猗县差异无统计学意义(χ2=0.057,P=0.811),万荣县差异有统计学意义(χ2=5.505,P=0.019),栾川县差异无统计学意义(χ2=2.129,P=0.145)。结论三个县健康人群乙脑病毒中和抗体保护率不同,这可能与当地乙脑的流行状况以及疫苗的接种情况有关。
|
| 关 键 词： | 流行性乙脑脑炎病毒 中和抗体 中和试验 |
| 收稿时间： | 2009-11-20 |
Neutralizing antibody level of Japanese encephalitis virus among healthy population in some areas in Shanxi province and Henan province |
| |
| FU Shi-hong,YIN Zun-dong,GAO Xiao-yan,WANG Huan-yu,ZHAI Ru-fang,ZHANG Yan-ping,MEN Wei-shan,ZOU Wen-qing,LV Zhi,TANG Xiao-yan,CHEN Shu-zhen,TANG Bo-ming,YAO Hai-wei,WANG Ze-yi,CHANG Shao-ying,LIANG Shao-lin,LIANG Xiao-feng,LIANG Guo-dong.Institute for Viral Disease Control , Prevention,Chinese Center for Disease Control , Prevention,Beijing ,China.Neutralizing antibody level of Japanese encephalitis virus among healthy population in some areas in Shanxi province and Henan province[J].Disease Surveillance,2010,25(2):99-102. |
| |
| Authors: | FU Shi-hong YIN Zun-dong GAO Xiao-yan WANG Huan-yu ZHAI Ru-fang ZHANG Yan-ping MEN Wei-shan ZOU Wen-qing LV Zhi TANG Xiao-yan CHEN Shu-zhen TANG Bo-ming YAO Hai-wei WANG Ze-yi CHANG Shao-ying LIANG Shao-lin LIANG Xiao-feng LIANG Guo-dongInstitute for Viral Disease Control Prevention Chinese Center for Disease Control Prevention Beijing China |
| |
| Affiliation: | 1.Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052,China |
| |
| Abstract: | Objective To investigate neutralizing antibody level of Japanese encephalitis virus among healthy people in some areas in Shanxi province and Henan province.Methods Serum samples collected were diluted by 1∶10,1∶20,1∶40,1∶80 to conduct neutralization test.The result interpretation will rely on both the cytopathic effect and the ELISA results.Results The results indicated that the neutralizing antibody protection rate in Linyi county（87.6%） was the highest,followed by Luanchun county（58.2%） and Wanrong county（51.4%）.By chi-square test,the difference on neutralizing antibody protection rate between Linyi county and Wanrong county had statistically significance（χ2=42.812,P=0.000）,while there was no statistically significant difference（χ2=1.466,P=0.226） between Luanchuan county and Wanrong county.There was statistically significant difference of neutralizing antibody protection rate between age group more than 40 years and age group less than 40 years in Wanrong county（χ2=5.505,P=0.019）,but no statistically significant differences were observed in Linyi county and Luanchuan county（χ2=0.057,P=0.811;χ2=2.129,P=0.145）.Conclusion The neutralizing antibody protection rate varied in 3 counties,which might relate with the local Japanese encephalitis prevalence and vaccination coverage. |
| |
| Keywords: | Japanese encephalitis virus neutralizing antibody neutralization test |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《疾病监测》浏览原始摘要信息 |
|
点击此处可从《疾病监测》下载全文 |
|
