| 卵巢癌与非编码RNA研究进展 |
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| 引用本文： | 揭嘉慧,张 颖.卵巢癌与非编码RNA研究进展[J].医学信息,2019,0(5):39-42. |
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| 作者姓名： | 揭嘉慧 张 颖 |
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| 作者单位： | （1.广东医科大学，广东 湛江 524002；2.广东医科大学附属医院，广东 湛江 524002） |
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| 摘 要： | 卵巢癌是全球女性因癌症死亡的第5大病因，尽早明确诊断并积极治疗是改善预后的有效方法。随着测序技术的不断发展，人们发现了大量的种类丰富的非编码RNA。ncRNAs在细菌、真菌和哺乳动物等多种生物体的活动中可作为致癌驱动因子和肿瘤抑制因子，对肿瘤的发生、发展起到调控作用，ncRNA有望成为肿瘤诊治的新型生物标志物和治疗靶点。探索ncRNA可为卵巢癌的研究提供一些系统性新思路。现将卵巢癌相关ncRNA最新研究进展进行综述，并着重讨论微小RNA（miRNA）、长链非编码RNA（lncRNA）及环状RNA（circRNA）在卵巢癌中的作用。
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| 关 键 词： | 卵巢癌 非编码RNA ncRNAs 肿瘤抑制因子 |
Progress in Research on Ovarian Cancer and Non-coding RNA |
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| JIE Jia-hui,ZHANG Ying.Progress in Research on Ovarian Cancer and Non-coding RNA[J].Medical Information,2019,0(5):39-42. |
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| Authors: | JIE Jia-hui ZHANG Ying |
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| Affiliation: | (1.Guangdong Medical University,Zhanjiang 524002,Guangdong,China;2.the Affiliated Hospital of Guangdong Medical University,Zhanjiang 524002,Guangdong,China) |
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| Abstract: | Ovarian cancer is the fifth leading cause of female cancer death in the world. Early diagnosis and active treatment are effective methods to improve prognosis. With the development of sequencing technology, it has been discovered that a large number of non-coding RNA.ncRNAs can be used as carcinogenic driver and tumor suppressor in the activities of bacteria, fungi and mammals. NcRNA is expected to be a new biomarker and therapeutic target for tumor diagnosis and treatment. Exploring ncRNA may provide some systematic new ideas for the study of ovarian cancer. In this paper, the latest research progress of ovarian cancer-related ncRNA is reviewed, and the role of micro-RNA (miRNA), long-chain non-coding RNA (lncRNA)and cyclic RNA (circRNA)in ovarian cancer is emphatically discussed. |
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| Keywords: | Ovarian cancer Non-coding RNA ncRNAs Tumor suppressor |
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