| 微流控浓度梯度芯片的开发与生物化学应用研究 |
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| 引用本文： | 石环环,,曹禺,周亚诺,,万亚茹,,赵亚丽.微流控浓度梯度芯片的开发与生物化学应用研究[J].中国医学物理学杂志,2021,0(10):1299-1303. |
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| 作者姓名： | 石环环 曹禺 周亚诺 万亚茹 赵亚丽 |
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| 作者单位： | 1.南昌航空大学教育部无损检测重点实验室， 江西 南昌 330000； 2.南昌航空大学测试与光电工程学院生物医学工程系， 江西 南昌 330000； 3.长沙市第四医院/湖南师范大学附属长沙医院， 湖南 长沙 410083 |
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| 摘 要： | 在生物化学分析中系统研究样本与不同浓度组分间的相互作用是至关重要的。微流控芯片技术能够在微米级的通道内完成精确的液体控制，近年来被普遍应用于生物化学分析领域。微流控浓度梯度芯片是一种能够快速构建稳定生物化学浓度梯度的工具，能够与大多数细胞培养、化学分析等技术相结合，为传统的生化分析提供新平台。本文综述微流控浓度梯度芯片的形成机制及其在生物化学等领域的应用，为拓宽浓度梯度相关应用研究提供新思路。
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| 关 键 词： | 微流控浓度梯度芯片 药物筛选 毒性分析 材料合成 综述 |
Development of microfluidic concentration gradient chip and its application in biochemistry |
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| SHI Huanhuan,,CAO Yu,ZHOU Yanuo,,WAN Yaru,,ZHAO Yali.Development of microfluidic concentration gradient chip and its application in biochemistry[J].Chinese Journal of Medical Physics,2021,0(10):1299-1303. |
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| Authors: | SHI Huanhuan CAO Yu ZHOU Yanuo WAN Yaru ZHAO Yali |
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| Affiliation: | 1. Key Laboratory of Nondestructive Testing, Ministry of Education, Nanchang Hangkong University, Nanchang 330000, China 2. Department of Biomedical Engineering, School of Testing and Optoelectronic Engineering, Nanchang Hangkong University, Nanchang 330000, China 3. Changsha Hospital of Hunan Normal University/the Forth Hospital of Changsha, Changsha 410083 |
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| Abstract: | Abstract: It is important to systematically study the interactions between samples and different concentrations of components in biochemical analysis. Microfluidic chip technology has been widely used in biochemical analysis in recent years, because it can realize accurate liquid control in micron-sized channel. Microfluidic concentration gradient chip is a tool that can rapidly construct stable biochemical concentration gradient and can be combined with most cell culture, chemical analysis and other techniques, offering a new platform for traditional biochemical analysis. Herein the formation mechanism of microfluidic concentration gradient chip and its application in biochemistry and other fields are reviewed, thereby providing a new idea for broadening the application research related to concentration gradient. |
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| Keywords: | Keywords: microfluidic concentration gradient chip drug screening toxicity analysis chemotaxis materials synthesis review |
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