灵芝多糖对顺铂引起的呕吐具抑制作用 |
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引用本文: | 颜艳,白文忠,王立安,裴林,杨洁,马永青,李华光.灵芝多糖对顺铂引起的呕吐具抑制作用[J].菌物学报,2009,28(3):456-462. |
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作者姓名: | 颜艳 白文忠 王立安 裴林 杨洁 马永青 李华光 |
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作者单位: | 1. 河北师范大学生命科学学院,石家庄,050016 2. 河北师范大学生命科学学院,石家庄,050016;河北体育学院运动人体科学系,石家庄,050041 3. 河北医科大学中医药研究所,石家庄,050031 |
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摘 要: | 以雄性昆明小鼠为实验材料,研究灵芝多糖对顺铂引起呕吐的抑制作用。实验分为5组,生理盐水+生理盐水组:腹腔注射0.9% NaCl两次,格拉司琼+顺铂组:腹腔注射格拉司琼和顺铂,生理盐水+顺铂组:腹腔注射0.9% NaCl和顺铂,灵芝多糖+生理盐水组:腹腔注射灵芝多糖和0.9% NaCl,灵芝多糖+顺铂组:腹腔注射灵芝多糖和顺铂,两种成分的注射间隔为30min。上述处理每天1次,连续5d,比较各组小鼠对高岭土的摄取量和脑内Fos蛋白表达水平。结果显示:顺铂可增加小鼠高岭土摄取量和脑内Fos蛋白表达水平,而格拉司琼和灵芝多糖可减少小鼠对高岭土的摄取量并降低脑内Fos蛋白表达水平。因此认为灵芝多糖可有效抑制顺铂引起的恶心呕吐。
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关 键 词: | 5-HT3受体拮抗剂 恶心呕吐 异食癖 Fos蛋白表达水平 |
Inhibitory effects of Ganoderma lucidum polysaccharides on cisplatin-induced vomit |
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Authors: | YAN Yan BAI Wen-Zhong WANG Li-An PEI Lin YANG Jie MA Yong-Qing LI Hua-Guang |
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Affiliation: | College of Life Sciences, Hebei Normal University, Shijiazhuang 050016, China |
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Abstract: | In order to investigate inhibitory effect of Ganoderma lucidum polysaccharides on cisplatin-induced vomit, male KM mice used as test animal, and they were divided into 5 treatment groups, normal saline + normal saline treatment group, granisetron + cisplatin treatment group, normal saline + cisplatin treatment group, Ganoderma lucidum polysaccharides + normal saline treatment group, and Ganoderma lucidum polysaccharides + cisplatin treatment group. The mice of 5 groups were injected intraperitoneally with f... |
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Keywords: | 5-HT3 receptor antagonist nausea/vomiting pica Fos protein expression |
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