| 男性不育与基因缺陷 |
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| 引用本文： | 阮健,杜卫东.男性不育与基因缺陷[J].遗传,2010,32(5):411-422. |
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| 作者姓名： | 阮健 杜卫东 |
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| 作者单位： | 安徽医科大学 省部共建教育部重要遗传病基因资源利用重点实验室, 安徽省基因研究重点实验室, 合肥230032 |
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| 基金项目： | 安徽省自然科学基金项目(编号：050430716, 090413114)和安徽省“十五”高校学科拔尖人才基金项目资助 |
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| 摘 要： | 目前全世界约有15%的育龄夫妇不育, 其中男性因素占50%。男性不育(Male infertility)病因复杂, 许多内外因素可导致男性不育, 其中生育相关基因缺陷是重要原因之一, 患者临床多表现为无精子症及少弱畸精子症。文章主要论述了已知基因缺陷与男性不育的关系。
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| 关 键 词： | 基因缺陷 突变 男性不育 |
| 收稿时间： | 2009-09-14 |
| 修稿时间： | 2009-11-24 |
Male infertility and gene defects |
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| RUAN Jian,DU Wei-Dong Key Lab of Gene Resource Utilization for Severe Hereditary Diseases of Ministry Education & Key Lab of Genome Research of Anhui Province,Anhui Medical University,Hefei ,China.Male infertility and gene defects[J].Hereditas,2010,32(5):411-422. |
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| Authors: | RUAN Jian DU Wei-Dong Key Lab of Gene Resource Utilization for Severe Hereditary Diseases of Ministry Education & Key Lab of Genome Research of Anhui Province Anhui Medical University Hefei China |
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| Affiliation: | Key Lab of Gene Resource Utilization for Severe Hereditary Diseases of Ministry Education & Key Lab of Genome Research of Anhui Province, Anhui Medical University, Hefei 230032, China |
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| Abstract: | About 15% of the couples at reproductive age worldwide suffer from infertility. It is estimated that 50% of the entity result from male itself. The mechanism of male infertility is quite complicated, attributing to inherent and environment factors of the infertility patients, of which defects of fertility-related genes are of importance for its occurrence. The clinical features of male infertility vary from azoospermia to oligoasthenoteratozoospermia. This paper presents the relationship between the known defects in genes and male infertility. |
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| Keywords: | male infertility gene defects mutation |
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