Synthesis and structure control of l‐lactic acid–glycolic acid copolymer by homo‐copolymerization |
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| Authors: | Huihui Yin Rui Wang Huan Ge Xiuqin Zhang Zhiguo Zhu |
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| Affiliation: | 1. Department of Polymer Science and Materials, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, China;2. Department of Materials Science & Engineering, Beijing Institute of Fashion, Technology, Beijing, China |
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| Abstract: | A two‐step direct melt copolymerization process of l ‐lactic acid (L ‐LA)/glycolic acid (GA) was developed: poly(l ‐lactic acid) (PLLA) and poly(glycolic acid) (PGA) with different molecular weight was first synthesized respectively by binary catalyst (tin chloride/p‐toluenesulfonic or tin chloride); and then poly(l ‐lactic‐co‐glycolic acid) (b‐PLGA) was produced by melt polymerization of the as‐prepared PLLA and PGA, wherein the composition and chain structure of b‐PLGA copolymers could be controlled by the molecular weight of PLLA. The chain structure and thermal properties of copolymers were studied by Wide‐angle X‐ray diffraction, nuclear magnetic resonance, differential scanning calorimetry, and thermogravimetric analysis. In comparison with the random PLGA (r‐PLGA) synthesized by one‐step direct melt polymerization, the average l ‐lactic blocks length (LLA) in b‐PLGA was longer while the average glycolic blocks length (LGA) in b‐PLGA was shorter which further resulted in the improved crystallinity and thermostability. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 41566. |
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| Keywords: | biomaterials crystallization polycondensation thermal properties thermogravimetric analysis (TGA) |
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