Poly(4‐vinyl pyridine)‐grafted graphene oxide for drug delivery and antimicrobial applications |
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| Authors: | Thangavelu Kavitha Inn‐Kyu Kang Soo‐Young Park |
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| Affiliation: | School of Applied Chemical Engineering, Kyungpook National University, Department of Polymer Science and Engineering, Daegu, Republic of Korea |
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| Abstract: | Graphene oxide (GO) was covalently functionalized with poly(4‐vinyl pyridine) (P4VP) by atom transfer radical polymerization for drug delivery and antimicrobial applications. The physiochemical properties, chemical structure, composition and morphology of the P4VP‐functionalized GO (GO‐P4VP) were studied. Simple physisorption of a cancer drug, camptothecin (CPT), via π ? π stacking and/or hydrophobic interactions on the GO‐P4VP was tested for drug loading and its release by altering the pH. The GO‐P4VP has low cytotoxicity, and the CPT‐loaded GO‐P4VP exhibited a high potency for killing cancer cells in vitro. Prominent antimicrobial properties against Escherichia coli and Staphylococcus aureus were also observed. Thus, the GO‐P4VP can be utilized as a drug delivery vector with high biocompatibility, solubility and stability in physiological solutions, a suitable payload capacity and excellent bacterial toxicity. Owing to its small size, low cost, large specific area, ready scalability and useful non‐covalent interactions, GO‐P4VP is a novel material for biomedical, industrial and environmental applications. © 2015 Society of Chemical Industry |
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| Keywords: | graphene oxide poly(4‐vinyl pyridine) grafting drug delivery |
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