Chaperone‐Polymer‐Assisted,Photodriven DNA Strand Displacement |
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| Authors: | Bohao Cheng Dr Hiromu Kashida Dr Naohiko Shimada Prof Dr Atsushi Maruyama Prof Dr Hiroyuki Asanuma |
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| Affiliation: | 1. Graduate School of Engineering, Nagoya University, Nagoya, Japan;2. Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan |
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| Abstract: | Photodriven DNA strand displacement by using a 2′,6′‐dimethylazobenzene‐tethered strand and poly(l ‐lysine)‐graft‐dextran (PLL‐g‐Dex) as a chaperone is reported. Rapid strand displacement was reversibly induced by UV and visible‐light irradiation without any toehold portion. To further improve the method, the concentration of PLL‐g‐Dex and the number of equivalents of the photoresponsive strand were optimised. Optimally, 64 % strand displacement was reversibly induced by alternating UV and visible‐light irradiation. |
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| Keywords: | DNA nanotechnology photochemistry polymers substituent effects |
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