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Bacterial Catabolism of Biphenyls: Synthesis and Evaluation of Analogues |
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| Authors: | Dr Sven Nerdinger Eugene Kuatsjah Dr Timothy E Hurst Inge Schlapp‐Hackl Prof?Dr Volker Kahlenberg Prof?Dr Klaus Wurst Prof?Dr Lindsay D Eltis Prof?Dr Victor Snieckus |
| Affiliation: | 1. Global Commercial Operations, Sandoz GmbH, Kundl, Austria;2. Life Sciences Centre, Vancouver, BC, Canada;3. Department of Chemistry, Queen's University, Kingston, ON, Canada;4. Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Center for Chemistry and Biomedicine, Innsbruck, Austria;5. Institute of Mineralogy and Petrography, University of Innsbruck, Innsbruck, Austria;6. Faculty of Chemistry and Pharmacy, University of Innsbruck, Innsbruck, Austria |
| Abstract: | A series of alkylated 2,3‐dihydroxybiphenyls has been prepared on the gram scale by using an effective Directed ortho Metalation–Suzuki–Miyaura cross‐coupling strategy. These compounds have been used to investigate the substrate specificity of the meta‐cleavage dioxygenase BphC, a key enzyme in the microbial catabolism of biphenyl. Isolation and characterization of the meta‐cleavage products will allow further study of related processes, including the catabolism of lignin‐derived biphenyls. |
| Keywords: | biphenyls cross-coupling metalation microbial catabolism substrate specificity |
