| 载阿霉素聚乳酸多孔微球的表征及释药性能 |
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| 引用本文： | 洪雅真,朱利会.载阿霉素聚乳酸多孔微球的表征及释药性能[J].化工进展,2018,37(3):1130-1136. |
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| 作者姓名： | 洪雅真 朱利会 |
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| 作者单位： | 1.华侨大学化工学院, 福建 厦门 361021;2.华侨大学生物材料与组织工程研究所, 福建 厦门 361021 |
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| 摘 要： | 以阿霉素（DOX）为小分子化学药物模型，采用吸附法对聚乳酸（poly-L-lactide，PLLA）多孔微球进行载药，采用场发射扫描电子显微镜（FE-SEM）、傅里叶变换红外光谱（FTIR）、X射线衍射（XRPD）及差示扫描量热（DSC）对DOX-PLLA复合微球的形貌粒径及空气动力学性能、药物及材料的理化性能、载药性能进行表征，并且研究了其载药量、包封率和体外释放性能。结果表明，不同载药量之间的PLLA多孔微球粒径并无显著差异，均具有良好的空气动力学性能，适合肺部可吸入给药的条件；化学组成未见明显改变，物理结构由结晶态变为无定形态；随载药量的增加（2.9%，4.0%，4.6%），包封率逐渐降低（56%，51%，44%）；药物的体外释放与原料药相比具有一定的缓释效果，最长释放时间可达5天，表明DOX-PLLA复合微球有望作为缓释制剂用于肺部给药。
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| 关 键 词： | 阿霉素 多孔微球 聚乳酸 体外释放 肺部给药 |
| 收稿时间： | 2017-09-04 |
Synthesis,characterization and in vitro drug release performance of poly-L-lactide porous microspheres |
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| HONG Yazhen,ZHU Lihui.Synthesis,characterization and in vitro drug release performance of poly-L-lactide porous microspheres[J].Chemical Industry and Engineering Progress,2018,37(3):1130-1136. |
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| Authors: | HONG Yazhen ZHU Lihui |
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| Affiliation: | 1 College of Chemical Engineering, Huaqiao University, Xiamen 361021, Fujian, China;
2 Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, Fujian, China |
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| Abstract: | Used the doxorubicin(DOX) as small molecule drug model,the DOX-loaded poly-L-lactide(PLLA) porous microspheres(PMs) were designed by adsorption method. The particle size distribution,aerodynamic properties,surface morphology,physical and chemical properties of PLLA PMs,and its successive drug-loaded conjugates,were detremined by various characterization techniques such as field emission-scanning electron microscope(FE-SEM),Fourier transform infrared spectrophotometry(FTIR),X-ray powder diffraction(XRPD) and differential scanning calorimetry(DSC),among others. Further,the drug loading,as well as encapsulation efficiencies and DOX-release performance in vitro,were also investigated. The PLLA PMs resulted in decreased encapsulation efficiencies(56%,51%,and 44%) with the increase in drug loading efficiencies(2.9%,4.0% and 4.6%). DOX-loaded PLLA PMs exhibited sustained-release profiles,in which the effect lasted more than 5 days. These porous microspheres can be used as an efficient platform due to their excellent aerodynamic properties and sustained release effect,which will potentially play a significant role in pulmonary drug delivery. |
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| Keywords: | doxorubicin porous microspheres poly-L-lactide in vitro release pulmonary drug delivery |
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