| 2015年诺贝尔化学奖钟情于基因组DNA“修理工” |
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| 引用本文： | 王静,彭斌,许兴智.2015年诺贝尔化学奖钟情于基因组DNA“修理工”[J].自然杂志,2015,37(6):418-423. |
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| 作者姓名： | 王静 彭斌 许兴智 |
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| 作者单位： | 首都师范大学生命科学学院DNA损伤应答北京市重点实验室，北京 100048; |
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| 摘 要： | 2015年诺贝尔化学奖授予了Tomas Lindahl、Paul Modrich和Aziz Sancar三位科学家,以表彰他们在"绘制细胞修复损伤DNA和捍卫遗传信息(完整性)的机制研究"方面所做出的杰出贡献。简要介绍了三位获奖者的研究工作和成就,以及DNA损伤修复与人类疾病(尤其是癌症)的发生、发展、诊断、治疗及预防的相关性。
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| 关 键 词： | 2015年诺贝尔化学奖 碱基切除修复 错配修复 核苷酸切除修复 |
| 收稿时间： | 2015-11-19 |
DNA-repair crew won the Nobel Prize in Chemistry 2015 |
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| WANG Jing,PENG Bin,XU Xingzhi.DNA-repair crew won the Nobel Prize in Chemistry 2015[J].Chinese Journal of Nature,2015,37(6):418-423. |
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| Authors: | WANG Jing PENG Bin XU Xingzhi |
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| Affiliation: | Beijing Key Laboratory of DNA Damage Response & College of Life Sciences, Capital Normal University, Beijing 100048, China |
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| Abstract: | The Nobel Prize in Chemistry 2015 was awarded jointly to Tomas Lindahl, Paul Modrich and Aziz Sancar for having mapped and explained how the cell repairs its DNA and safeguards the genetic information. In this overview, we brie?y introduced research achievements of the laureates and the link between DNA-repair and etiology, development, diagnosis, therapy, and the prevention of human diseases, cancer in particular. |
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| Keywords: | 2015 Nobel Prize in Chemistry base excision repair mismatch repair nucleotide excision repair |
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