| PELP1表达与胃癌演进及预后相关性分析 |
| |
| 引用本文： | 赵宝山,梁冠盈,许圣洁,乔慧,陈洪霞,马莹,鞠学萍,王麟.PELP1表达与胃癌演进及预后相关性分析[J].实用肿瘤学杂志,2022,36(1):31-36. |
| |
| 作者姓名： | 赵宝山 梁冠盈 许圣洁 乔慧 陈洪霞 马莹 鞠学萍 王麟 |
| |
| 作者单位： | 1.哈尔滨医科大学大庆校区基础医学院病理学教研室(大庆 163319);2.哈尔滨医科大学附属肿瘤医院病理科;3.宁波临床病理诊断中心;4.大庆油田总医院消化内科;5.大庆市第四医院病理科 |
| |
| 基金项目： | 黑龙江省卫生健康委员会项目(编号:2017-174);黑龙江省高校科研基金(编号:JFXN2019010)。 |
| |
| 摘 要： | 目的 探讨脯氨酸-谷氨酸-亮氨酸富集蛋白1(Proline,glutamate and leucine rich protein 1,PELP1)表达与胃癌演进及预后的关系及意义.方法 采用免疫组化检测39例正常胃组织、48例低级别不典型增生胃组织、28例高级别不典型增生胃组织、77例胃癌组织中PELP1蛋白表达水平,...
|
| 关 键 词： | 胃癌 脯氨酸-谷氨酸-亮氨酸富集蛋白1 免疫组织化学 生存分析 |
| 收稿时间： | 2021-08-06 |
Analysis of the correlation between PELP1 expression and gastric cancer progression and prognosis |
| |
| ZHAO Baoshan,LIANG Guanying,XU Shengjie,QIAO Hui,CHEN Hongxia,MA Ying,JU Xueping,WANG Lin.Analysis of the correlation between PELP1 expression and gastric cancer progression and prognosis[J].Journal of Practical Oncology,2022,36(1):31-36. |
| |
| Authors: | ZHAO Baoshan LIANG Guanying XU Shengjie QIAO Hui CHEN Hongxia MA Ying JU Xueping WANG Lin |
| |
| Affiliation: | 1. Department of Pathology,College of Basic Medical Sciences,Harbin Medical University-Daqing,Daqing 163319,China;2. Department of Pathology,Harbin Medical University Cancer Hospital;3. Ningbo Clinicopathological Diagnosis Center;4. Department of Gastroenterology,Daqing Oilfield General Hospital;5. Department of Pathology,Fourth Hospital of Daqing |
| |
| Abstract: | Objective The aim of this study was to investigate the relationship and significance of proline,glutamate and leucine rich protein 1(PELP1)in the progression and prognosis of gastric cancer.Methods Immunohistochemistry was used to detect the expression of PELP1 protein in 39 normal gastric tissues,48 low-grade atypical hyperplasia gastric tissues,28 high-grade atypical hyperplasia gastric tissues,and 77 gastric cancer tissues.The expression of PELP1 in different stages of gastric cancer was observed.The correlation between the level of PELP1 and clinicopathological parameters of gastric cancer was analyzed.Kaplan-Meier Plotter,an online cancer survival analysis tool,was used to analyze the relationship between PELP1 expression in gastric cancer and overall survival(OS),survival before first progression(FP)and post progression survival(PPS).Results The level of PELP1 increased gradually during the progression of gastric cancer,and the differences were significant(P<0.05);The expression of PELP1 in gastric cancer was significantly correlated with lymph node metastasis,low tumor differentiation and high clinical stage(P<0.05);The OS,FP and PPS of patients with high level of PELP1 were significantly shorter than those with low level of PELP1(P<0.05).Conclusion The high expression of PELP1 is involved in the progression of gastric cancer and suggests a poor prognosis for patients. |
| |
| Keywords: | Gastric Cancer Proline glutamic and leucine rich protein 1 Immunohistochemistry Survival analysis |
| 本文献已被 维普 等数据库收录！ |
| 点击此处可从《实用肿瘤学杂志》浏览原始摘要信息 |
|
点击此处可从《实用肿瘤学杂志》下载全文 |
|
