Single Ho3+‐Doped Upconversion Nanoparticles for High‐Performance T2‐Weighted Brain Tumor Diagnosis and MR/UCL/CT Multimodal Imaging |
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| Authors: | Dalong Ni Wenbo Bu Shengjian Zhang Xiangpeng Zheng Ming Li Huaiyong Xing Qingfeng Xiao Yanyan Liu Yanqing Hua Liangping Zhou Weijun Peng Kuaile Zhao Jianlin Shi |
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| Affiliation: | 1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, P.R. China;2. Department of radiology, Shanghai Cancer Hospital, Fudan University, Shanghai, P.R. China;3. Department of radiation oncology, Shanghai Huadong Hospital, Fudan University, Shanghai, P.R. China |
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| Abstract: | Multimodal bio‐imaging has attracted great attention for early and accurate diagnosis of tumors, which, however, suffers from the intractable issues such as complicated multi‐step syntheses for composite nanostructures and interferences among different modalities like fluorescence quenching by MRI contrast agents (e.g., magnetic iron oxide NPs). Herein, the first example of T2‐weighted MR imaging of Ho3+‐doped upconversion nanoparticles (UCNPs) is presented, which, very attractively, could also be simultaneously used for upconversion luminesence (UCL) and CT imaging, thus enabling high performance multi‐modal MRI/UCL/CT imagings in single UCNPs. The new finding of T2‐MRI contrast enhancement by integrated sensitizer (Yb3+) and activator (Ho3+) in UCNPs favors accurate MR diagnosis of brain tumor and provides a new strategy for acquiring T2‐MRI/optical imaging without fluorescence quenching. Unlike other multi‐phased composite nanostructures for multimodality imaging, this Ho3+‐doped UCNPs are featured with simplicity of synthesis and highly efficient multimodal MRI/UCL/CT imaging without fluorescence quenching, thus simplify nanostructure and probe preparation and enable win–win multimodality imaging. |
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| Keywords: | upconversion nanoparticles Holmium MRI fluorescence quenching brain tumors |
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