| 中医综合养生干预对绝经后骨密度低下女性骨密度和骨代谢标志物的影响 |
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| 引用本文： | 林依怀,王史潮,吕存贤,王庆来.中医综合养生干预对绝经后骨密度低下女性骨密度和骨代谢标志物的影响[J].中华全科医学,2020,18(8):1373. |
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| 作者姓名： | 林依怀 王史潮 吕存贤 王庆来 |
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| 作者单位： | 温州市中医院中医骨伤科, 浙江 温州 325000 |
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| 基金项目： | 浙江省中医药科技计划项目(2019ZB122) |
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| 摘 要： | 目的 常规药物治疗绝经后骨密度低下的临床疗效并不理想,且长期服用存在副作用,因此本研究拟探讨中医综合养生干预对绝经后骨密度低下女性骨密度的改善效果。 方法 将2016年1月—2018年1月温州市中医院收治的124例绝经后骨密度低下患者按照随机数字表法分为观察组和对照组,各62例,对照组给予钙尔奇碳酸钙D3片+常规饮食及活动,观察组给予中医综合养生干预,连续干预6个月,比较治疗前、治疗6个月2组骨密度及骨代谢标志物变化水平的差异。 结果 与治疗前相比,治疗6个月对照组股骨粗隆(0.57±0.07)的骨密度明显升高(P<0.05),观察组第1~4腰椎(0.77±0.06)、股骨颈(0.75±0.07)、股骨粗隆(0.61±0.08)及Wards三角区(0.60±0.09)的骨密度(g/cm2)均明显升高(均P<0.05);对照组Ⅰ型胶原羧基端肽β特殊序列(0.49±0.06)ng/mL]、血钙(2.28±0.07)mmol/L]、骨特异性碱性磷酸酶(326.37±100.82)U/L]水平较治疗前明显升高(均P<0.05),观察组Ⅰ型前胶原氨基端肽(50.13±12.76)ng/mL]、骨钙素氨基中分子片段(21.24±6.77)ng/mL]、骨特异性碱性磷酸酶(418.72±129.90)U/L]水平均明显升高(均P<0.05),Ⅰ型胶原羧基端肽β特殊序列(0.43±0.09)ng/mL]、血钙(2.21±0.07)mmol/L]水平均明显降低(均P<0.05);观察组骨密度及骨代谢标志物水平较对照组明显改善(均P<0.05)。 结论 中医综合养生干预能在短期内提高绝经后骨密度低下患者的骨密度,同时改善骨形成标志物及骨吸收标志物表达水平。
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| 关 键 词： | 中医综合养生干预 绝经 骨密度 骨代谢标志物 |
| 收稿时间： | 2020-01-21 |
Effect of comprehensive health care intervention of traditional Chinese medicine on bone mineral density and bone metabolic markers in postmenopausal women with low bone mineral density |
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| Affiliation: | Department of Orthopedics and Traumatology,Wenzhou Hospital of Traditional Chinese Medicine,Wenzhou,Zhejiang 325000,China |
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| Abstract: | Objective To explore the effect of comprehensive health care intervention of traditional Chinese medicine on the improvement of bone mineral density in postmenopausal women with low bone mineral density. Methods Total 124 postmenopausal patients with low bone mineral density in our hospital from January 2016 to January 2018 were randomly divided into observation group and control group, 62 cases in each group. The control group was given calcium carbonate D3 + regular diet and activities for 6 months. The observation group was given comprehensive health care intervention of traditional Chinese medicine for 6 months. The differences of bone mineral density and bone metabolic markers between the two groups before and 6 months after treatment were compared. Results Compared with that before treatment, the bone mineral density of the control group(0.57±0.07) was significantly higher(P<0.05), and the bone mineral density of the 1 st-4 th lumbar vertebrae(0.77±0.06), femoral neck(0.75±0.07), femoral trochanter(0.61±0.08) and wards triangle(0.60±0.09) in the observation group were significantly higher(P<0.05). In the control group,the levels of carboxy terminal peptide β special sequence(0.49±0.06)ng/mL], blood calcium(2.28±0.07) mmol/L] and bone specific alkaline phosphatase(326.37±100.82) U/L]were significantly higher than that before treatment(P<0.05). In the observation group, the levels of amino terminal peptide(50.13±12.76) ng/mL], middle molecular fragment of osteocalcin(21.24±6.77) ng/mL], and bone specific alkaline phosphatase(418.72±129.90) U/L] were significantly higher(all P<0.05), while the levels of carboxy terminal peptide β special sequence(0.43±0.09) ng/mL] and blood calcium(2.21±0.07) mmol/L] were decreased significantly(P<0.05). Compared with the control group, the bone mineral density and bone metabolic markers of the observation group were significantly improved(all P<0.05). Conclusion The comprehensive health care intervention of traditional Chinese medicine can improve the bone mineral density of postmenopausal patients with low bone mineral density in a short time, and improve the expression level of bone formation markers and bone resorption markers. |
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