| 视网膜色素上皮与近视发病机制研究进展 |
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| 引用本文： | 姜倩,蒋文君,徐福如,毕宏生.视网膜色素上皮与近视发病机制研究进展[J].眼科新进展,2020,0(10):985-989. |
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| 作者姓名： | 姜倩 蒋文君 徐福如 毕宏生 |
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| 作者单位： | 250014 山东省济南市，山东中医药大学（姜倩，徐福如）； 250002 山东省济南市，山东省中西医结合眼病防治重点实验室，山东中医药大学眼科研究所（蒋文君）；250002 山东省济南市，山东省高校中西医结合眼病防治技术（强化）重点实验室，山东中医药大学眼科研究所，山东中医药大学附属眼科医院（毕宏生） |
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| 摘 要： | 近视是视力损害的主要原因之一，常伴发视网膜脱离、近视性黄斑病变等并发症。体外和体内研究均表明，近视发生过程中视网膜色素上皮（retinal pigment epithelium，RPE）组织形态学和离子稳态发生变化，且视网膜色素上皮分泌的多巴胺、乙酰胆碱等神经递质和转化生长因子-β、肝细胞生长因子和胰岛素样生长因子等多种生长因子与近视发展进程密切相关，参与眼轴延长和近视性巩膜基质重塑。本文就近视视网膜色素上皮形态学改变及神经递质和生长因子在近视发生发展中的作用进行综述，为理解近视发展的分子机制及探索新的治疗方法提供新思路。
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| 关 键 词： | 视网膜色素上皮 神经递质 生长因子 视黄酸 近视 |
Advances in the relationship between retinal pigment epithelium and the pathogenesis of myopia |
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| JIANG Qian,JIANG Wenjun,XU Furu,BI Hongsheng.Advances in the relationship between retinal pigment epithelium and the pathogenesis of myopia[J].Recent Advances in Ophthalmology,2020,0(10):985-989. |
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| Authors: | JIANG Qian JIANG Wenjun XU Furu BI Hongsheng |
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| Affiliation: | 1.Shandong University of Traditional Chinese Medicine2.Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases,Eye Institute of Shandong University of Traditional Chines |
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| Abstract: | Myopia, one of the leading causes of visual impairment, often accompanied by complications such as retinal detachment and myopic macular disease. Both in vitro and in vivo studies has shown that changes in retinal pigment epithelium (RPE) histomorphology and ionic homeostasis during myopia, neurotransmitters such as dopamine and acetylcholine and various growth factors such as transforming growth factor-β, hepatocyte growth factor and insulin-like growth factor secreted by the retinal pigment epithelium play an important role in myopia scleral matrix remodeling and axial elongation. This article reviews the role of RPE morphological changes, neurotransmitters and growth factors in the development of myopia during myopia, and provides new ideas for understanding the molecular mechanisms of myopia development and exploring new treatments. |
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| Keywords: | retinal pigment epithelium neurotransmitter growth factor retinoic acid myopia |
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