| 2010-2015年河南省5岁以下儿童病毒性腹泻病原谱分析 |
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| 引用本文： | 赵嘉咏,申晓靖,王泽乾,张白帆,苏佳,黄学勇.2010-2015年河南省5岁以下儿童病毒性腹泻病原谱分析[J].现代预防医学,2016,0(23):4240-4244. |
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| 作者姓名： | 赵嘉咏 申晓靖 王泽乾 张白帆 苏佳 黄学勇 |
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| 作者单位： | 1.河南省疾病预防控制中心,河南 郑州 450016;2.淇县疾病预防控制中心,河南 淇县 456750 |
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| 摘 要： | 目的 分析河南省腹泻儿童轮状、杯状、星状及肠道腺病毒病原谱及流行病学特征。方法 采集2010-2015年四个哨点医院5岁以下儿童腹泻粪便1 963份,ELISA法检测A组轮状病毒并进行G/P基因分型,多重RT-PCR/PCR检测B/C组轮状、杯状、星状与肠道腺病毒；对阳性病例流行病学资料进行统计分析。结果 共检出阳性样本1 234份(包括混合感染样本76份),总阳性率62.9%:轮状病毒887份(A组802份,B组18份,C组67份),阳性率45.2%；杯状病毒264份(诺如I型52份,诺如II型173份,扎如39份),阳性率13.4%；星状病毒131份,阳性率6.7%；肠道腺病毒28份,阳性率1.4%。A组轮状病毒以G9P8]优势型别,存在秋季和春季两个较显著高峰；杯状病毒以诺如II型为主,存在一个春夏季感染高峰。阳性病例存在不同程度的发热、腹泻、呕吐等临床症状,性别及城乡分布存在病原学差异。结论 河南省5岁以下儿童中存在较高的腹泻病毒感染率,以A组轮状与诺如II型病毒为主,不同类别病毒感染的流行病学及临床特点不同。
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| 关 键 词： | 腹泻病毒 儿童 病原谱 基因型别 流行病学特征 |
Pathogen spectrum analysis of viral diarrhea in children below 5 years old of Henan,2010-2015 |
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| ZHAO Jia-yong,SHEN Xiao-jing,WANG Ze-qian,ZHANG Bai-fan,SU Jia,HUANG Xue-yong.Pathogen spectrum analysis of viral diarrhea in children below 5 years old of Henan,2010-2015[J].Modern Preventive Medicine,2016,0(23):4240-4244. |
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| Authors: | ZHAO Jia-yong SHEN Xiao-jing WANG Ze-qian ZHANG Bai-fan SU Jia HUANG Xue-yong |
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| Affiliation: | *Henan Provincial Center for Disease Control and Prevention,Zhengzhou,Henan 450016,China |
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| Abstract: | Objective To investigate the pathogen spectrum and epidemiological characteristics of rotavirus,calicivirus,astrovirus and enteric adenovirus of children with diarrhea in Henan Province. Methods 1 963 stool samples were collected in four sentinel hospitals from children below 5 years old in 2010-2015.Rotavirus pathogens in group A were detected by ELISA method,and positive cases were made G/P genotyping.While group B/C (rotavirus,calicivirus,astrovirus and enteric adenovirus) were detected by RT-PCR/PCR.The epidemiological data of positive cases were statistically analyzed. Results 1 234 positive samples were detected from 1963 diarrhea samples,including 76 mixed infection samples,and total positive rate was 62.9%,including 887 samples of rotavirus (802 cases of group A,18 cases of group B,67 cases of group C),which positive rate was 45.2%.The positive rates of 264,131 and 28 samples from calicivirus (52 cases of Novovirus I,173 cases of NovovirusII,sapovirus 39cases) and astrovirus were 13.4%,6.7% and 1.4%.Rotavirus A gene type was composed mainly of G9P8] and there were two seasonal positive rate peaks in autumn and spring.Novovirus II was the main type of calicivirus and there was one spring/summer infection peak.Positive cases had different degrees of clinical symptoms,such as fever,diarrhea,vomiting,et al.Gender and region distributions were different,according to the types of pathogen infection. Conclusion There are higher infection rate of diarrhea virus among children below 5 years old in Henan Province,and different types of virus infection present different epidemiological and clinical features. |
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| Keywords: | Diarrhea virus Children Pathogen spectrum Genotyping Epidemiological feature |
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