| 非霍奇金淋巴瘤侵犯骨髓时Cx43表达情况 |
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| 引用本文： | 刘思恒,易小翠,冉岑霞,李 佳,彭贤贵,张 曦.非霍奇金淋巴瘤侵犯骨髓时Cx43表达情况[J].现代肿瘤医学,2020,0(5):810-812. |
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| 作者姓名： | 刘思恒 易小翠 冉岑霞 李 佳 彭贤贵 张 曦 |
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| 作者单位： | 1.陆军军医大学第二附属医院血液病医学中心，重庆 400037；2.重庆市沙坪坝区人民医院检验科，重庆 400030 |
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| 基金项目： | 重庆市社会事业与民生保障科技创新专项（编号:cstc2016shms-ztzx10003） |
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| 摘 要： | 目的:研究非霍奇金淋巴瘤(non-Hodgkin' s lymphoma,NHL)骨髓侵犯患者骨髓病灶中间隙连接蛋白（connexin，Cx）43表达情况。 方法:选取我院确诊的非霍奇金淋巴瘤骨髓侵犯患者26例，骨髓组织中查见呈灶性分布且已通过免疫组化证实为反应性淋巴细胞增生的患者9例，正常骨髓组织10例行免疫组化染色，根据阳性率及阳性程度评分后进行统计学分析。 结果:Cx43在NHL样本中的阳性率（30.8%）低于在反应性淋巴细胞增生样本（88.9%）及正常样本（100%）中的阳性率，差异有统计学意义（P<0.05）。而反应性淋巴细胞增生样本和正常样本间Cx43阳性率无统计学意义（P>0.05），但反应性淋巴细胞增生样本的阳性积分明显低于正常样本（P<0.05）。结论:非霍奇金淋巴瘤骨髓侵犯时病灶处Cx43表达情况显著低于反应性淋巴细胞增生及正常骨髓组织。
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| 关 键 词： | 非霍奇金淋巴瘤 骨髓侵犯 间隙连接蛋白43 |
Observation of Cx43 expression in non-Hodgkin' s lymphoma with bone marrow invasion |
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| Liu Siheng,Yi Xiaocui,Ran Cenxia,Li Jia,Peng Xiangui,Zhang Xi.Observation of Cx43 expression in non-Hodgkin' s lymphoma with bone marrow invasion[J].Journal of Modern Oncology,2020,0(5):810-812. |
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| Authors: | Liu Siheng Yi Xiaocui Ran Cenxia Li Jia Peng Xiangui Zhang Xi |
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| Affiliation: | 1.Department of Hematology，Second Affiliated Hospital，Army Medical University，Chongqing 400037，China；2.Clinical Laboratory，People's Hospital of Chongqing Shapingba District，Chongqing 400030，China. |
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| Abstract: | Objective:To study the expression of connexin (Cx) 43 in bone marrow lesions of patients with non-Hodgkin's lymphoma with bone marrow invasion.Methods:26 patients with bone marrow invasion of non-Hodgkin's lymphoma were confirmed in our hospital.9 patients with focal distribution of bone marrow were confirmed as reactive lymphocyte proliferation by immunohistochemistry.10 patients with normal bone marrow tissue were selected for immunohistochemical staining.Then statistical analysis was made according to the positive rate and the positive degree score.Results:The positive rate of Cx43 in NHL samples (30.8%) was lower than that in reactive lymphocyte proliferation samples (88.9%) and normal samples (100%)，and the difference was statistically significant (P<0.05).The positive rate of Cx43 between reactive lymphocyte proliferation samples and normal samples was not statistically significant (P>0.05)，but the positive scores of reactive lymphocyte proliferation samples were significantly lower than those of normal samples (P<0.05).Conclusion:Cx43 expression in the focus of non-Hodgkin's lymphoma is significantly lower than reactive lymphocyte proliferation and normal. |
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| Keywords: | non-Hodgkin's lymphoma bone marrow involvement connexin 43 |
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