| Acsl4在浸润性乳腺癌组织中的表达及其临床意义 |
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| 引用本文： | 刘永娟,李小静,刘秀萍,' target='_blank'>,杨 珂,舒维清,王长一.Acsl4在浸润性乳腺癌组织中的表达及其临床意义[J].现代肿瘤医学,2020,0(12):2050-2053. |
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| 作者姓名： | 刘永娟 李小静 刘秀萍 ' target='_blank'> 杨 珂 舒维清 王长一 |
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| 作者单位： | 1.复旦大学附属上海市第五人民医院病理科，上海 200240;
2.复旦大学基础医学院病理与病理生理学系，上海 200032 |
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| 基金项目： | 复旦大学附属上海市第五人民医院院级医学重点专科（编号:2017WYZDZK08） |
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| 摘 要： | 目的:探讨Acsl4在浸润性乳腺癌组织中的表达及其临床意义。方法:采用免疫组织化学法检测108例浸润性乳腺癌组织中Acsl4的表达。结果:108例浸润性乳腺癌组织中,33例(30.6%)阳性表达,75例(69.4%)阴性表达。组织学G3级的乳腺癌组织中Acsl4阳性率为42.3%(22/52),高于G1+G2级的阳性率(19.6%,11/56),差异具有统计学意义(P<0.05)。ER阳性组织的Acsl4的阳性率15.8%(6/38),低于ER阴性的病例(38.6%,27/70),差异具有统计学意义(P<0.05)。Acsl4的表达与患者年龄、肿瘤大小、淋巴结是否转移、HER2、PR、p53、Ki67的表达情况无统计学意义的相关性(P均>0.05)。结论:Acsl4在浸润性乳腺癌组织中存在异常表达,其阳性表达与乳腺癌患者组织学分级较高及ER阴性表达密切相关。
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| 关 键 词： | 浸润性乳腺癌 长链脂酰辅酶A合成酶4 雌激素受体 免疫组织化学 |
The expression of Acsl4 in invasive breast carcinoma tissues and its clinical significance |
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| Liu Yongjuan,Li Xiaojing,Liu Xiuping,' target='_blank'>,Yang Ke,Shu Weiqing,Wang Changyi.The expression of Acsl4 in invasive breast carcinoma tissues and its clinical significance[J].Journal of Modern Oncology,2020,0(12):2050-2053. |
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| Authors: | Liu Yongjuan Li Xiaojing Liu Xiuping ' target='_blank'> Yang Ke Shu Weiqing Wang Changyi |
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| Affiliation: | 1.Department of Pathology,Shanghai Fifth People's Hospital,Fudan University,Shanghai 200240,China;2Department of Pathology and Pathophysiology,Medical College,Fudan University,Shanghai 200032,China. |
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| Abstract: | Objective:To examine the expression and the clinical significance of Acsl4 in invasive breast carcinoma.Methods:The protein expression of Acsl4 in paraffin-embedded samples from 108 patients with invasive breast carcinoma was detected by immunohistochemical staining.Results:Of all 108 cases examined,33 cases had positive and 75 cases had negative expression of Acsl4.The positive expression rate of Acsl4 protein was 42.3%(22/52) in the cases of histological grade G3,which was significantly higher than those in cases of grade G1+G2(19.6%,11/56)（P<0.05).The positive expression rate of Acsl4 protein was 15.8%（6/38) in ER-positive cases,which was significantly lower than those in ER-negative cases（38.6%)（P<0.05).The positive expression of Acsl4 was not related to the patients' age,tumor size,lymph node metastasis,expression of HER2,PR,p53,and Ki67(P>0.05).Conclusion:Acsl4 is abnormally expressed in invasive breast carcinoma,and its positive expression is closely related to higher histological grade and negative ER expression. |
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| Keywords: | invasive breast carcinoma acyl-CoA synthetase long-chain family member 4（Acsl4) estrogen receptor immunohistochemistry |
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