| 基于数据挖掘分析S100A6在肝细胞癌中的表达及临床意义 |
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| 引用本文： | 李 鹏,' target='_blank'>,梁跃东,刘建西,黎中恒,杨 勤,杨小燕.基于数据挖掘分析S100A6在肝细胞癌中的表达及临床意义[J].现代肿瘤医学,2020,0(12):2089-2094. |
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| 作者姓名： | 李 鹏 ' target='_blank'> 梁跃东 刘建西 黎中恒 杨 勤 杨小燕 |
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| 作者单位： | 1.贵阳市公共卫生救治中心，贵州 贵阳 550004;2.贵州医科大学基础医学院，贵州 贵阳 550004;3.贵州医科大学附属医院儿科，贵州 贵阳 550004 |
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| 基金项目： | 贵州省科技计划项目（编号:黔科合LH字［2016］7240号）；贵州省科技厅学术新苗项目（编号:黔科合平台人才［2017］5718） |
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| 摘 要： | 目的:探讨S100蛋白超家族A6（S100 family member A6,S100A6）在肝细胞癌(hepatocellular carcinoma,HCC)中的表达及临床意义。方法:利用Oncomine生物信息学在线分析网站，挖掘分析大型癌症公共数据癌症基因组图谱(TCGA)及GEO(Gene Expression Omnibus)中肝癌S100A6 mRNA的表达信息，基于TCGA中的肝癌数据，利用GEPIA、Kaplan-Meier Plotter进行患者生存分析。结果:在Oncomine数据库中，前后共收集了337项不同类型的研究结果，关于S100A6基因表达有统计学差异的研究结果有30个，其中S100A6基因表达降低的研究有12项，表达增高的研究有18项。共有4项研究涉及S100A6在HCC癌组织和正常肝组织中的表达，与正常肝组织相比，S100A6在HCC中高表达（P=4.58E-4）。此外，S100A6表达量与HCC总体生存率存在相关性，高表达S100A6的患者总体生存率较差（P=0.048、P=0.005 1）。进一步结合TNM分期进行分析发现，S100A6表达在Ⅳ期最高。S100A6表达与Ⅰ（P=0.31）、Ⅱ（P=0.2）期患者预后无相关性，在Ⅲ期患者中，高表达S100A6的患者总体生存率较差（P=0.007 1）。结论:本研究通过对基因芯片数据库中肿瘤相关基因信息的深入挖掘和剖析，发现S100A6基因在肝细胞癌组织中呈现高表达，并且与肝细胞癌预后关系密切，尤其对HCC Ⅲ期患者有预后指导意义。
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| 关 键 词： | 数据挖掘 S100A6 表达 预后 |
Expression of S100A6 and its prognostic role in hepatocellular carcinoma:Analysis based on the data-mining |
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| Li Peng,' target='_blank'>,Liang Yuedong,Liu Jianxi,Li Zhongheng,Yang Qin,Yang Xiaoyan.Expression of S100A6 and its prognostic role in hepatocellular carcinoma:Analysis based on the data-mining[J].Journal of Modern Oncology,2020,0(12):2089-2094. |
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| Authors: | Li Peng ' target='_blank'> Liang Yuedong Liu Jianxi Li Zhongheng Yang Qin Yang Xiaoyan |
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| Affiliation: | 1.Guiyang Public Health Treatment Center,Guizhou Guiyang 550004,China;2.School of Basic Medicine,Guizhou Medcial University,Guizhou Guiyang 550004,China;3.Department of Pediatric，Affiliated Hospital of Guizhou Medcial University,Guizhou Guiyang 550004,Chi |
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| Abstract: | Objective:To investigate the expression and clinical significance of S100 protein superfamily A6 (S100 family member A6,S100A6) in hepatocellular carcinoma （HCC）.Methods:Using Oncomine bioinformatics online analysis website,the expression information of S100A6 mRNA in TCGA and GEO (Gene Expression Omnibus) of large public data of cancer was mined and analyzed.Based on TCGA data of liver cancer,overall survival was analyzed by using GEPIA and Kaplan-Meier Plotter.Results:337 studies of different types were collected in Oncomine database,which 30 studies showed statistically significant differences in S100A6 expression,18 studies showed increased,and 12 studies showed decreased of S100A6 expression.Four studies involved the expression of S100A6 in HCC and normal tissues,and S100A6 was highly expressed in HCC compared with the control group (P=4.58E-4).Furthermore,S100A6 expression was correlated with HCC overall survival,and patients with high S100A6 expression had poor overall survival （P=0.048,P=0.005 1）.Further analysis found that combining TNM staging S100A6 expression in the highest Ⅳ stage.S100A6 expression was no correlated with the prognosis of patients with Ⅰ（P=0.31） and Ⅱ（P=0.2）stage,but overall survival rate in patients with high expression of S100A6 was poor in Ⅲ stage patients （P=0.007 1）.Conclusion:In this study,tumor related gene information in the gene chip database was deeply mined and analyzed.The results showed that S100A6 gene was highly expressed in hepatocellular carcinoma tissues and was closely related to the prognosis of hepatocellular carcinoma,especially in patients with HCC Ⅲ stage has a guiding significance to the prognosis. |
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| Keywords: | data-mining S100A6 expression prognosis |
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