| 灵芪胶囊对H22荷瘤小鼠COX-2蛋白表达的影响 |
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| 引用本文： | 刘晓冬,代贵江,刘波,苏云明.灵芪胶囊对H22荷瘤小鼠COX-2蛋白表达的影响[J].天津中医药大学学报,2013,30(2):99-101. |
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| 作者姓名： | 刘晓冬 代贵江 刘波 苏云明 |
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| 作者单位： | 牡丹江医学院附属第二医院, 牡丹江 157010;黑龙江中医药大学, 哈尔滨 150040;牡丹江医学院附属第二医院, 牡丹江 157010;黑龙江中医药大学, 哈尔滨 150040;牡丹江医学院附属第二医院, 牡丹江 157010;黑龙江中医药大学, 哈尔滨 150040;牡丹江医学院附属第二医院, 牡丹江 157010;黑龙江中医药大学, 哈尔滨 150040 |
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| 基金项目： | 2005黑龙江中医药大学科研基金资助项目(200503). |
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| 摘 要： | 目的] 研究灵芪胶囊(LQC)的抗肿瘤作用的机制。方法] 以免疫组化方法检测荷瘤小鼠血管生成因子环氧化酶-2(COX-2)、表达的变化, 研究LQC对肿瘤血管生成的抑制作用。结果] LQC能够下调血管生长因子COX-2的表达而抑制肿瘤生长。结论] LQC通过影响COX-2的表达, 抑制肿瘤新生血管生成, 发挥抗肿瘤作用。
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| 关 键 词： | 灵芪胶囊 抗肿瘤 H22细胞株 血管生成因子环氧化酶-2 |
| 收稿时间： | 2012/8/14 0:00:00 |
Effect of Lingqi capsule on the expression of COX-2 in H22 tumor-bearing mice |
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| LIU Xiao-dong,DAI Gui-jiang,LIU Bo and SU Yun-ming.Effect of Lingqi capsule on the expression of COX-2 in H22 tumor-bearing mice[J].Journal of Tianjin University of Traditonal Chinese Medicine,2013,30(2):99-101. |
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| Authors: | LIU Xiao-dong DAI Gui-jiang LIU Bo and SU Yun-ming |
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| Affiliation: | The Second Affiliated Hospital of Mudanjiang Medical College, Mudanjiang 157010, China;Heilongjiang University of TCM, Ha''erbin 150040, China;The Second Affiliated Hospital of Mudanjiang Medical College, Mudanjiang 157010, China;Heilongjiang University of TCM, Ha''erbin 150040, China;The Second Affiliated Hospital of Mudanjiang Medical College, Mudanjiang 157010, China;Heilongjiang University of TCM, Ha''erbin 150040, China;The Second Affiliated Hospital of Mudanjiang Medical College, Mudanjiang 157010, China;Heilongjiang University of TCM, Ha''erbin 150040, China |
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| Abstract: | Objective] To study the anti-tumor effect of Lingqi capsules (LQC) and further explore the mechanism of action. Methods] The expression of angiogenic factor COX-2 was detected in tumor-bearing mice with immunohistochemical methods and to the LQC''s inhibitory action to tumor angiogenesis was detected also. Results] LQC could inhibit the tumor angiogenesis by down-regulating the expression of angiogenic factor COX-2. Conclusion] LQC shows its anti-tumor effect by influencing the expression of angiogenesis-correlated factor and inhibiting the tumor angiogenesis. |
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| Keywords: | Lingqi capsule Anti-tumor H22 COX-2 |
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